{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:33:10Z","timestamp":1787614390059,"version":"build-2736575974"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An expansion of the GGGGCC hexanucleotide in the non-coding region of C9orf72 represents the most common cause of familial amyotrophic lateral sclerosis. The objective was to describe and analyse the clinical and genetic features of amyotrophic lateral sclerosis patients with C9orf72 mutations in a large population. Between November 2011 and December 2020, clinical and genetic characteristics of n = 248 patients with amyotrophic lateral sclerosis carrying C9orf72 mutations were collected from the clinical and scientific network of German motoneuron disease centres. Clinical parameters included age of onset, diagnostic delay, family history, neuropsychological examination, progression rate, phosphorylated neurofilament heavy chain levels in CSF and survival. The number of repeats was correlated with the clinical phenotype. The clinical phenotype was compared to n = 84 patients with SOD1 mutations and n = 2178 sporadic patients without any known disease-related mutations. Patients with C9orf72 featured an almost balanced sex ratio with 48.4% (n = 120) women and 51.6% (n = 128) men. The rate of 33.9% patients (n = 63) with bulbar onset was significantly higher compared to sporadic (23.4%, P = 0.002) and SOD1 patients (3.1%, P &amp;lt; 0.001). Of note, 56.3% (n = 138) of C9orf72, but only 16.1% of SOD1 patients reported a negative family history (P &amp;lt; 0.001). The GGGGCC hexanucleotide repeat length did not influence the clinical phenotypes. Age of onset (58.0, interquartile range 52.0\u201363.8) was later compared to SOD1 (50.0, interquartile range 41.0\u201358.0; P &amp;lt; 0.001), but earlier compared to sporadic patients (61.0, interquartile range 52.0\u201369.0; P = 0.01). Median survival was shorter (38.0 months) compared to SOD1 (198.0 months, hazard ratio 1.97, 95% confidence interval 1.34\u20132.88; P &amp;lt; 0.001) and sporadic patients (76.0 months, hazard ratio 2.34, 95% confidence interval 1.64\u20133.34; P &amp;lt; 0.001). Phosphorylated neurofilament heavy chain levels in CSF (2880, interquartile range 1632\u20134638\u2005pg\/ml) were higher compared to sporadic patients (1382, interquartile range 458\u20132839\u2005pg\/ml; P &amp;lt; 0.001). In neuropsychological screening, C9orf72 patients displayed abnormal results in memory, verbal fluency and executive functions, showing generally worse performances compared to SOD1 and sporadic patients and a higher share with suspected frontotemporal dementia. In summary, clinical features of patients with C9orf72 mutations differ significantly from SOD1 and sporadic patients. Specifically, they feature a more frequent bulbar onset, a higher share of female patients and shorter survival. Interestingly, we found a high proportion of patients with negative family history and no evidence of a relationship between repeat lengths and disease severity.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad087","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T22:42:03Z","timestamp":1679352123000},"source":"Crossref","is-referenced-by-count":26,"title":["Clinical and genetic features of amyotrophic lateral sclerosis patients with<i>C9orf72<\/i>mutations"],"prefix":"10.1093","volume":"5","author":[{"given":"Maximilian","family":"Wiesenfarth","sequence":"first","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kornelia","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1841-954X","authenticated-orcid":false,"given":"Simon","family":"Witzel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Weiland","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1535-3146","authenticated-orcid":false,"given":"David","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Schuster","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Freischmidt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Lul\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for ALS and other Motor Neuron Disorders, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health , 13353 Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-7386","authenticated-orcid":false,"given":"Martin","family":"Regensburger","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg (FAU) , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Grehl","sequence":"additional","affiliation":[{"name":"Alfried Krupp Hospital , R\u00fcttenscheid, 45131 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Emmer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Halle University Hospital , 06120 Halle , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Petri","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hannover Medical School , 30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Gro\u00dfkreutz","sequence":"additional","affiliation":[{"name":"Precision Neurology, University of L\u00fcbeck , 23538 L\u00fcbeck , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annekathrin","family":"R\u00f6diger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jena University Hospital , 07745 Jena , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-6010","authenticated-orcid":false,"given":"Robert","family":"Steinbach","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jena University Hospital , 07745 Jena , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klopstock","sequence":"additional","affiliation":[{"name":"Department of Neurology with Friedrich-Baur-Institute, University Hospital of Ludwig-Maximilians-University , 80336 M\u00fcnchen , Germany"},{"name":"German Centre for Neurodegenerative Diseases (DZNE) Site Munich , 81377 Munich , Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy) , 81377 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Reilich","sequence":"additional","affiliation":[{"name":"Department of Neurology with Friedrich-Baur-Institute, University Hospital of Ludwig-Maximilians-University , 80336 M\u00fcnchen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Sch\u00f6berl","sequence":"additional","affiliation":[{"name":"Department of Neurology with Friedrich-Baur-Institute, University Hospital of Ludwig-Maximilians-University , 80336 M\u00fcnchen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Neurology, Diakonissen Hospital , 68163 Mannheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Hagenacker","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro and Behavioral Sciences (C-TNBS), University Hospital Essen , 45127 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Weyen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ruhr-University Bochum, BG-Kliniken Bergmannsheil , 44789 Bochum , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zeller","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of W\u00fcrzburg , 97080 W\u00fcrzburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert C","family":"Ludolph","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"},{"name":"German Centre for Neurodegenerative Diseases (DZNE) Site Ulm , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Dorst","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University , 89081 Ulm , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"issue":"10","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1111\/ene.14393","article-title":"Amyotrophic lateral sclerosis: A clinical review","volume":"27","author":"Masrori","year":"2020","journal-title":"Eur J Neurol"},{"issue":"12","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S1474-4422(18)30404-6","article-title":"Global, regional, and national burden of motor neuron diseases 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"17","author":"GBD 2016 Motor Neuron Disease Collaborators","year":"2018","journal-title":"Lancet Neurol"},{"issue":"2","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"issue":"10","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1212\/WNL.0000000000003067","article-title":"Comparative analysis of C9orf72 and sporadic disease in an ALS clinic population","volume":"87","author":"Umoh","year":"2016","journal-title":"Neurology"},{"issue":"3","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S1474-4422(12)70014-5","article-title":"Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: A population-based cohort study","volume":"11","author":"Byrne","year":"2012","journal-title":"Lancet Neurol"},{"key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"661447","DOI":"10.3389\/fncel.2021.661447","article-title":"C9ORF72: What it is, what it does, and why it matters","volume":"15","author":"Smeyers","year":"2021","journal-title":"Front Cell Neurosci"},{"issue":"9","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41582-018-0047-2","article-title":"C9orf72-mediated ALS and FTD: Multiple pathways to disease","volume":"14","author":"Balendra","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"6125","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1126\/science.1232927","article-title":"The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD\/ALS","volume":"339","author":"Mori","year":"2013","journal-title":"Science"},{"issue":"2","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fnagi.2017.00068","article-title":"ALS clinical trials review: 20 years of failure. Are we any closer to registering a new treatment?","volume":"9","author":"Petrov","year":"2017","journal-title":"Front Aging Neurosci"},{"issue":"7","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1474-4422(17)30115-1","article-title":"Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: A randomised, double-blind, placebo-controlled trial","volume":"16","author":"Writing Group","year":"2017","journal-title":"Lancet Neurol"},{"issue":"10","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMoa1916945","article-title":"Trial of sodium phenylbutyrate-taurursodiol for amyotrophic lateral sclerosis","volume":"383","author":"Paganoni","year":"2020","journal-title":"N Engl J Med"},{"issue":"2","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1056\/NEJMoa2003715","article-title":"Phase 1-2 trial of antisense oligonucleotide tofersen for SOD1 ALS","volume":"383","author":"Miller","year":"2020","journal-title":"N Engl J Med"},{"issue":"5","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"1214.e1","DOI":"10.1016\/j.neurobiolaging.2013.11.034","article-title":"Polymerase chain reaction and Southern blot-based analysis of the C9orf72 hexanucleotide repeat in different motor neuron diseases","volume":"35","author":"H\u00fcbers","year":"2014","journal-title":"Neurobiol Aging"},{"issue":"1","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-021-00266-x","article-title":"A natural history comparison of SOD1-mutant patients with amyotrophic lateral sclerosis between Chinese and German populations","volume":"10","author":"Tang","year":"2021","journal-title":"Transl Neurodegener"},{"issue":"3","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00401-014-1251-9","article-title":"The widening spectrum of C9ORF72-related disease; genotype\/phenotype correlations and potential modifiers of clinical phenotype","volume":"127","author":"Cooper-Knock","year":"2014","journal-title":"Acta Neuropathol"},{"issue":"1","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1038\/s41598-017-02364-1","article-title":"Age-related penetrance of the C9orf72 repeat expansion","volume":"7","author":"Murphy","year":"2017","journal-title":"Sci Rep"},{"key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3389\/fnins.2019.00485","article-title":"Comparative analysis of C9orf72 and sporadic disease in a large multicenter ALS population: The effect of male sex on survival of C9orf72 positive patients","volume":"13","author":"Trojsi","year":"2019","journal-title":"Front Neurosci"},{"key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fnins.2020.00316","article-title":"Clinical phenotype and inheritance in patients with C9ORF72 hexanucleotide repeat expansion: Results from a large French cohort","volume":"14","author":"Esselin","year":"2020","journal-title":"Front Neurosci"},{"issue":"2","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"e665","DOI":"10.1212\/NXG.0000000000000665","article-title":"ALS In Finland: Major genetic variants and clinical characteristics of patients with and without the C9orf72 hexanucleotide repeat expansion","volume":"8","author":"Laaksovirta","year":"2022","journal-title":"Neurol Genet"},{"issue":"2","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00415-022-11426-y","article-title":"Factors predicting disease progression in C9ORF72 ALS patients","volume":"270","author":"Mandrioli","year":"2022","journal-title":"J Neurol"},{"issue":"4","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1474-4422(12)70043-1","article-title":"Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: A cross-sectional study","volume":"11","author":"Majounie","year":"2012","journal-title":"Lancet Neurol"},{"issue":"5","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1159\/000516752","article-title":"Estimated prevalence and incidence of amyotrophic lateral sclerosis and SOD1 and C9orf72 genetic variants","volume":"55","author":"Brown","year":"2021","journal-title":"Neuroepidemiology"},{"issue":"15","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1212\/WNL.0000000000004494","article-title":"Sex differences in the prevalence of genetic mutations in FTD and ALS: A meta-analysis","volume":"89","author":"Curtis","year":"2017","journal-title":"Neurology"},{"issue":"1","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/ana.24980","article-title":"Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis","volume":"82","author":"Gendron","year":"2017","journal-title":"Ann Neurol"},{"issue":"11","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/S1474-4422(14)70219-4","article-title":"Analysis of amyotrophic lateral sclerosis as a multistep process: A population-based modelling study","volume":"13","author":"Al-Chalabi","year":"2014","journal-title":"Lancet Neurol"},{"issue":"7","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"e635","DOI":"10.1212\/WNL.0000000000005996","article-title":"The multistep hypothesis of ALS revisited: The role of genetic mutations","volume":"91","author":"Chi\u00f2","year":"2018","journal-title":"Neurology"},{"issue":"1","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/mus.27085","article-title":"Risk factors for amyotrophic lateral sclerosis: A regional United States case-control study","volume":"63","author":"Andrew","year":"2021","journal-title":"Muscle Nerve"},{"issue":"3","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3390\/ijerph17030857","article-title":"Clinical and lifestyle factors and risk of amyotrophic lateral sclerosis: A population-based case-control study","volume":"17","author":"Filippini","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"2023033117095377400_","first-page":"181","article-title":"Risk factors for amyotrophic lateral sclerosis","volume":"7","author":"Ingre","year":"2015","journal-title":"Clin Epidemiol"},{"issue":"2","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00401-017-1713-y","article-title":"DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients","volume":"134","author":"Zhang","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"1","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00401-014-1365-0","article-title":"Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier","volume":"129","author":"Russ","year":"2015","journal-title":"Acta Neuropathol"},{"issue":"6","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/jnnp-2015-310734","article-title":"The cognitive profile of ALS: A systematic review and meta-analysis update","volume":"87","author":"Beeldman","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1136\/jnnp-2020-323671","article-title":"Deficits in verbal fluency in presymptomatic C9orf72 mutation gene carriers-a developmental disorder","volume":"91","author":"Lul\u00e9","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13024-020-0359-8","article-title":"Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers","volume":"15","author":"Jackson","year":"2020","journal-title":"Mol Neurodegener"},{"issue":"10","key":"2023033117095377400_","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S1474-4422(13)70210-2","article-title":"Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): A cross-sectional cohort study","volume":"12","author":"van Blitterswijk","year":"2013","journal-title":"Lancet Neurol"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcad087\/49572743\/fcad087.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/5\/2\/fcad087\/49717037\/fcad087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/5\/2\/fcad087\/49717037\/fcad087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T07:08:42Z","timestamp":1702105722000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcad087\/7081385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcad087","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,4,1]]},"published":{"date-parts":[[2023,3,2]]},"article-number":"fcad087"}}