{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:12:14Z","timestamp":1789751534668,"version":"4.0.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DC018287"],"award-info":[{"award-number":["DC018287"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>NF2\u2013related schwannomatosis is a genetic disorder characterized by neurologic tumours, most typically vestibular schwannomas that originate on the vestibulo-cochlear nerve(s). Although vestibular symptoms can be disabling, vestibular function has never been carefully analysed in NF2\u2013related schwannomatosis. Furthermore, chemotherapy (e.g. bevacizumab) can reduce tumour volume and improve hearing in NF2\u2013related schwannomatosis, but nothing is known about its vestibular effects. In this report, we studied the three primary vestibular-mediated behaviours (eye movements, motion perception and balance), clinical vestibular disability (dizziness and ataxia), and imaging and hearing in eight untreated patients with NF2\u2013related schwannomatosis and compared their results with normal subjects and patients with sporadic, unilateral vestibular schwannoma tumours. We also examined how bevacizumab affected two patients with NF2\u2013related schwannomatosis. Vestibular schwannomas in NF2\u2013related schwannomatosis degraded vestibular precision (inverse of variability, reflecting a reduced central signal-to-noise ratio) but not vestibular accuracy (amplitude relative to ideal amplitude, reflecting the central signal magnitude) and caused clinical disability. Bevacizumab improved vestibular precision and clinical disability in both patients with NF2\u2013related schwannomatosis but did not affect vestibular accuracy. These results demonstrate that vestibular schwannoma tumours in our NF2\u2013related schwannomatosis population degrade the central vestibular signal-to-noise ratio, while bevacizumab improves the signal-to-noise ratio, changes that can be explained mechanistically by the addition (schwannoma) and suppression (bevacizumab) of afferent neural noise.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad089","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T15:27:24Z","timestamp":1679585244000},"source":"Crossref","is-referenced-by-count":10,"title":["Vestibular dysfunction in <i>NF2<\/i>\u2013related schwannomatosis"],"prefix":"10.1093","volume":"5","author":[{"given":"Amsal S","family":"Madhani","sequence":"first","affiliation":[{"name":"Department of Otolargynology, Massachusetts Eye and Ear , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"King","sequence":"additional","affiliation":[{"name":"Department of 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