{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T17:07:29Z","timestamp":1769879249735,"version":"3.49.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Zentrum f\u00fcr Infektionsforschung","award":["FKZ8009801908"],"award-info":[{"award-number":["FKZ8009801908"]}]},{"name":"Deutsche Zentrum f\u00fcr Infektionsforschung","award":["Fasttrack 1.921"],"award-info":[{"award-number":["Fasttrack 1.921"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["FR1720\/18-1"],"award-info":[{"award-number":["FR1720\/18-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["SFB1328"],"award-info":[{"award-number":["SFB1328"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008662","name":"Joachim-Herz-Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008662","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Persistent somatic and neuropsychiatric symptoms have been frequently described in patients after infection with severe acute respiratory syndrome coronavirus 2 even after a benign clinical course of the acute infection during the early phases of the coronavirus severe acute respiratory syndrome coronavirus 2 pandemic and are part of Long COVID. The Omicron variant emerged in November 2021 and has rapidly become predominant due to its high infectivity and suboptimal vaccine cross-protection. The frequency of neuropsychiatric post-acute sequelae after infection with the severe acute respiratory syndrome coronavirus 2 Omicron and adequate vaccination status is not known. Here, we aimed to characterize post-acute symptoms in individuals with asymptomatic or mildly symptomatic breakthrough infection with severe acute respiratory syndrome coronavirus 2. These individuals had either proven infection with the Omicron variant (n = 157) or their infection occurred in 2022 where Omicron was the predominant variant of severe acute respiratory syndrome coronavirus 2 in Germany (n = 107). This monocentric cross-sectional study was conducted at the University Medical Center Hamburg-Eppendorf between 11 February 2022 and 11 April 2022. We employed questionnaires addressing self-reported somatic symptom burden (Somatic Symptom Scale 8) and neuropsychiatric symptoms including mood (Patient Health Questionnaire 2), anxiety (Generalized Anxiety Disorder 7), attention (Mindful Attention Awareness Scale) and fatigue (Fatigue Assessment Scale) in a cohort of hospital workers. Scores were compared between 175 individuals less than 4 weeks after positive testing for severe acute respiratory syndrome coronavirus 2, 88 individuals more than 4 weeks after positive testing and 87 severe acute respiratory syndrome coronavirus 2 uninfected controls. The majority (n = 313; 89.5%) of included individuals were vaccinated at least three times. After recovery from infection, no significant differences in scores assessing neuropsychiatric and somatic symptoms were detected between the three groups (severe acute respiratory syndrome coronavirus 2 uninfected controls, individuals less and more than 4 weeks after positive testing) independent of age, sex, preconditions and vaccination status. In addition, self-reported symptom burden did not significantly correlate with the number of vaccinations against severe acute respiratory syndrome coronavirus 2, time from recovery or the number of infections. Notably, in all three groups, the mean scores for each item of our questionnaire lay below the pathological threshold. Our data show that persistent neuropsychiatric and somatic symptoms after recovery from severe acute respiratory syndrome coronavirus 2 infection in fully vaccinated hospital workers do not occur more frequently than that in uninfected individuals. This will guide healthcare professionals in the clinical management of patients after recovery from breakthrough infections with severe acute respiratory syndrome coronavirus 2.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad092","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T17:56:37Z","timestamp":1679766997000},"source":"Crossref","is-referenced-by-count":5,"title":["Absence of self-reported neuropsychiatric and somatic symptoms after Omicron variant SARS-CoV-2 breakthrough infections"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1306-2708","authenticated-orcid":false,"given":"Marcel S","family":"Woo","sequence":"first","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf , Hamburg 20251 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Mayer","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf , Hamburg 20251 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Theo","family":"Brehm","sequence":"additional","affiliation":[{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg-L\u00fcbeck-Borstel-Riems , Hamburg 20246 , Germany"},{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , Hamburg 20246 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Occupational Safety and Health, University Medical Center Hamburg-Eppendorf , Hamburg 20246 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Weigel","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf , Hamburg 20246 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-3378","authenticated-orcid":false,"given":"Bernd","family":"L\u00f6we","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf , Hamburg 20246 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansgar W","family":"Lohse","sequence":"additional","affiliation":[{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg-L\u00fcbeck-Borstel-Riems , Hamburg 20246 , Germany"},{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , Hamburg 20246 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marylyn M","family":"Addo","sequence":"additional","affiliation":[{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg-L\u00fcbeck-Borstel-Riems , Hamburg 20246 , Germany"},{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , Hamburg 20246 , Germany"},{"name":"Institute for Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf , Hamburg 20246 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gerloff","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf , Hamburg 20251 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2591-6387","authenticated-orcid":false,"given":"Johannes K M","family":"Knobloch","sequence":"additional","affiliation":[{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg-L\u00fcbeck-Borstel-Riems , Hamburg 20246 , Germany"},{"name":"Institute of Medical Microbiology, Virology and Hygiene, Department for Infection Prevention and Control, University Medical Center Hamburg-Eppendorf , Hamburg 20246 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5033-1938","authenticated-orcid":false,"given":"Julian","family":"Schulze zur Wiesch","sequence":"additional","affiliation":[{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg-L\u00fcbeck-Borstel-Riems , Hamburg 20246 , Germany"},{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf , Hamburg 20246 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-2420","authenticated-orcid":false,"given":"Manuel A","family":"Friese","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf , Hamburg 20251 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"issue":"3","key":"2023040812283898000_","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00103-021-03406-w","article-title":"Erratum zu: Milde COVID-19-Verl\u00e4ufe bei Mitarbeitenden einer Universit\u00e4tsklinik","volume":"65","author":"von Felden","year":"2022","journal-title":"Bundesgesundheitsblatt - Gesundheitsforsch - 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