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As such, recent studies have focused on characterizing protein and related clearance pathways involving perivascular flow of neurofluids, but human studies of these pathways are limited owing to limited methods for evaluating neurofluid circulation non-invasively in vivo. Here, we utilize non-invasive MRI methods to explore surrogate measures of CSF production, bulk flow and egress in the context of independent PET measures of amyloid-\u03b2 accumulation in older adults. Participants (N = 23) were scanned at 3.0\u2005T with 3D T2-weighted turbo spin echo, 2D perfusion-weighted pseudo-continuous arterial spin labelling and phase-contrast angiography to quantify parasagittal dural space volume, choroid plexus perfusion and net CSF flow through the aqueduct of Sylvius, respectively. All participants also underwent dynamic PET imaging with amyloid-\u03b2 tracer 11C-Pittsburgh Compound B to quantify global cerebral amyloid-\u03b2 accumulation. Spearman\u2019s correlation analyses revealed a significant relationship between global amyloid-\u03b2 accumulation and parasagittal dural space volume (rho = 0.529, P = 0.010), specifically in the frontal (rho = 0.527, P = 0.010) and parietal (rho = 0.616, P = 0.002) subsegments. No relationships were observed between amyloid-\u03b2 and choroid plexus perfusion nor net CSF flow. Findings suggest that parasagittal dural space hypertrophy, and its possible role in CSF-mediated clearance, may be closely related to global amyloid-\u03b2 accumulation. These findings are discussed in the context of our growing understanding of the physiological mechanisms of amyloid-\u03b2 aggregation and clearance via neurofluids.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad128","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T08:36:07Z","timestamp":1681806967000},"source":"Crossref","is-referenced-by-count":25,"title":["Parasagittal dural space hypertrophy and amyloid-\u03b2 deposition in Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1590-4144","authenticated-orcid":false,"given":"Alexander K","family":"Song","sequence":"first","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"},{"name":"Vanderbilt Brain Institute, Vanderbilt University , Nashville, TN 37232 , 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