{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:55:03Z","timestamp":1787313303387,"version":"build-2736575974"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":138,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Integrating cerebrospinal fluid-biomarkers into diagnostic workup of patients with sporadic cerebral amyloid angiopathy may support early and correct identification. We aimed to identify and validate clinical- and cerebrospinal fluid-biomarkers for in vivo diagnosis of cerebral amyloid angiopathy. This observational cohort study screened 2795 consecutive patients admitted for cognitive complaints to the academic departments of neurology and psychiatry over a 10-year period (2009\u20132018). We included 372 patients with available hemosiderin-sensitive MR imaging and cerebrospinal fluid-based neurochemical dementia diagnostics, i.e. A\u03b240, A\u03b242, t-tau, p-tau. We investigated the association of clinical- and cerebrospinal fluid-biomarkers with the MRI-based diagnosis of cerebral amyloid angiopathy, applying confounder-adjusted modelling, receiver operating characteristic and unsupervised cluster analyses. We identified 67 patients with cerebral amyloid angiopathy, 76 patients with Alzheimer\u2019s disease, 75 patients with mild cognitive impairment due to Alzheimer\u2019s disease, 76 patients with mild cognitive impairment with unlikely Alzheimer\u2019s disease and 78 healthy controls. Patients with cerebral amyloid angiopathy showed a specific cerebrospinal fluid pattern: average concentration of A\u00df40 [13 792\u2005pg\/ml (10 081\u201318 063)] was decreased compared to all controls (P &amp;lt; 0.05); A\u00df42 [634\u2005pg\/ml (492\u2013834)] was comparable to Alzheimer\u2019s disease and mild cognitive impairment due to Alzheimer\u2019s disease (P = 0.10, P = 0.93) but decreased compared to mild cognitive impairment and healthy controls (both P &amp;lt; 0.001); p-tau [67.3\u2005pg\/ml (42.9\u201391.9)] and t-tau [468\u2005pg\/ml (275\u2013698)] were decreased compared to Alzheimer\u2019s disease (P &amp;lt; 0.001, P = 0.001) and mild cognitive impairment due to Alzheimer\u2019s disease (P = 0.001, P = 0.07), but elevated compared to mild cognitive impairment and healthy controls (both P &amp;lt; 0.001). Multivariate modelling validated independent clinical association of cerebral amyloid angiopathy with older age [odds-ratio: 1.06, 95% confidence interval (1.02\u20131.10), P &amp;lt; 0.01], prior lobar intracerebral haemorrhage [14.00 (2.64\u201374.19), P &amp;lt; 0.01], prior ischaemic stroke [3.36 (1.58\u20137.11), P &amp;lt; 0.01], transient focal neurologic episodes (TFNEs) [4.19 (1.06\u201316.64), P = 0.04] and gait disturbance [2.82 (1.11\u20137.15), P = 0.03]. For cerebrospinal fluid-biomarkers per 1\u2005pg\/ml, both lower A\u00df40 [0.9999 (0.9998\u20131.0000), P &amp;lt; 0.01] and lower A\u00df42 levels [0.9989 (0.9980\u20130.9998), P = 0.01] provided an independent association with cerebral amyloid angiopathy controlled for all aforementioned clinical confounders. Both amyloid biomarkers showed good discrimination for diagnosis of cerebral amyloid angiopathy among adjusted receiver operating characteristic analyses (area under the receiver operating characteristic curves, A\u00df40: 0.80 (0.73\u20130.86), P &amp;lt; 0.001; A\u00df42: 0.81 (0.75\u20130.88), P &amp;lt; 0.001). Unsupervised Euclidian clustering of all cerebrospinal fluid-biomarker-profiles resulted in distinct segregation of cerebral amyloid angiopathy patients from all controls. Together, we demonstrate that a distinctive set of cerebrospinal fluid-biomarkers effectively differentiate cerebral amyloid angiopathy patients from patients with Alzheimer\u2019s disease, mild cognitive impairment with or without underlying Alzheimer\u2019s disease, and healthy controls. Integrating our findings into a multiparametric approach may facilitate diagnosing cerebral amyloid angiopathy, and may aid clinical decision-making, but warrants future prospective validation.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad159","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T00:03:24Z","timestamp":1684541004000},"source":"Crossref","is-referenced-by-count":29,"title":["Cerebrospinal fluid biomarkers for cerebral amyloid angiopathy"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0014-3389","authenticated-orcid":false,"given":"Jochen A","family":"Sembill","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91054 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Lusse","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91054 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5528-5141","authenticated-orcid":false,"given":"Mathias","family":"Linnerbauer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91054 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian I","family":"Spr\u00fcgel","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91054 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Mrochen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91054 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Knott","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91054 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Engelhorn","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91054 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Alexander","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91054 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnd","family":"Doerfler","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91054 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4369-6875","authenticated-orcid":false,"given":"Timo Jan","family":"Oberstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Maler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Lewczuk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen , Germany"},{"name":"Department of Neurodegeneration Diagnostics, Medical University of Bialystok, and Department of Biochemical Diagnostics, University Hospital of Bialystok , 15-090 Bialystok , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Rothhammer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91054 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schwab","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91054 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joji B","family":"Kuramatsu","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Erlangen, and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91054 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"issue":"7","key":"2023062806480154800_fcad159-B1","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/brain\/awx047","article-title":"Emerging concepts in sporadic cerebral amyloid angiopathy","volume":"140","author":"Charidimou","year":"2017","journal-title":"Brain"},{"issue":"2","key":"2023062806480154800_fcad159-B2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/jnnp-2011-301308","article-title":"Sporadic cerebral amyloid angiopathy revisited: Recent insights into pathophysiology and clinical spectrum","volume":"83","author":"Charidimou","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"7","key":"2023062806480154800_fcad159-B3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41582-018-0014-y","article-title":"Cerebral small vessel disease: From a focal to a global perspective","volume":"14","author":"Ter Telgte","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"2023062806480154800_fcad159-B4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/STROKEAHA.117.016990","article-title":"Diagnosis of cerebral amyloid angiopathy: Evolution of the Boston criteria","volume":"49","author":"Greenberg","year":"2018","journal-title":"Stroke"},{"issue":"9","key":"2023062806480154800_fcad159-B5","doi-asserted-by":"crossref","first-page":"e754","DOI":"10.1212\/WNL.0000000000005030","article-title":"Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis","volume":"90","author":"Charidimou","year":"2018","journal-title":"Neurology"},{"issue":"6","key":"2023062806480154800_fcad159-B6","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1001\/archneur.56.6.673","article-title":"Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: Differences between early- and late-onset Alzheimer disease and stability during the course of disease","volume":"56","author":"Andreasen","year":"1999","journal-title":"Arch Neurol"},{"key":"2023062806480154800_fcad159-B7","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fnagi.2018.00100","article-title":"Targeting beta-amyloid at the CSF: A new therapeutic strategy in Alzheimer\u2019s disease","volume":"10","author":"Menendez-Gonzalez","year":"2018","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"2023062806480154800_fcad159-B8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/ana.21694","article-title":"Cerebrospinal fluid amyloid beta40 is decreased in cerebral amyloid angiopathy","volume":"66","author":"Verbeek","year":"2009","journal-title":"Ann Neurol"},{"issue":"4","key":"2023062806480154800_fcad159-B9","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3233\/JAD-160400","article-title":"Cerebrospinal fluid Alzheimer\u2019s disease biomarkers in isolated supratentorial cortical superficial siderosis","volume":"54","author":"Renard","year":"2016","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"5","key":"2023062806480154800_fcad159-B10","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/jcbfm.2015.25","article-title":"Cerebral amyloid angiopathy-related atraumatic convexal subarachnoid hemorrhage: An ARIA before the tsunami","volume":"35","author":"Martinez-Lizana","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"2023062806480154800_fcad159-B11","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3233\/JAD-215208","article-title":"Cerebrospinal fluid profile of tau, phosphorylated tau, Abeta42, and Abeta40 in probable cerebral amyloid angiopathy","volume":"87","author":"Grangeon","year":"2022","journal-title":"J Alzheimer\u2019s Dis"},{"key":"2023062806480154800_fcad159-B12","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.783996","article-title":"Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy: New data and quantitative meta-analysis","volume":"14","author":"Margraf","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"2023062806480154800_fcad159-B13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the national institute on aging-Alzheimer's association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimer\u2019s Dement"},{"issue":"3","key":"2023062806480154800_fcad159-B14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1212\/WNL.0000000000004826","article-title":"Practice guideline update summary: Mild cognitive impairment: Report of the guideline development, dissemination, and implementation subcommittee of the American academy of neurology","volume":"90","author":"Petersen","year":"2018","journal-title":"Neurology"},{"key":"2023062806480154800_fcad159-B15","year":"2012"},{"key":"2023062806480154800_fcad159-B16","doi-asserted-by":"crossref","first-page":"231\u2013","DOI":"10.1212\/WNL.0000000000012234","article-title":"Cerebral amyloid angiopathy-related transient focal neurologic episodes","volume":"97","author":"Smith","year":"2021","journal-title":"Neurology"},{"key":"2023062806480154800_fcad159-B17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fnhum.2017.00353","article-title":"Guidelines for assessment of gait and reference values for spatiotemporal gait parameters in older adults: The biomathics and Canadian gait consortiums initiative","volume":"11","author":"Beauchet","year":"2017","journal-title":"Front Hum Neurosci"},{"issue":"9","key":"2023062806480154800_fcad159-B18","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00702-009-0277-y","article-title":"Neurochemical dementia diagnostics: A simple algorithm for interpretation of the CSF biomarkers","volume":"116","author":"Lewczuk","year":"2009","journal-title":"J Neural Transm"},{"issue":"2","key":"2023062806480154800_fcad159-B19","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3233\/JAD-150342","article-title":"Validation of the erlangen score algorithm for the prediction of the development of dementia due to Alzheimer\u2019s disease in pre-dementia subjects","volume":"48","author":"Lewczuk","year":"2015","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"3","key":"2023062806480154800_fcad159-B20","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/acn3.51001","article-title":"Hematoma enlargement characteristics in deep versus lobar intracerebral hemorrhage","volume":"7","author":"Sembill","year":"2020","journal-title":"Ann Clin Transl Neurol"},{"issue":"20","key":"2023062806480154800_fcad159-B21","doi-asserted-by":"crossref","first-page":"e1997","DOI":"10.1212\/WNL.0000000000200261","article-title":"Simplified Edinburgh CT criteria for identification of lobar intracerebral hemorrhage associated with cerebral amyloid angiopathy","volume":"98","author":"Sembill","year":"2022","journal-title":"Neurology"},{"issue":"8","key":"2023062806480154800_fcad159-B22","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1001\/jama.2015.0846","article-title":"Anticoagulant reversal, blood pressure levels, and anticoagulant resumption in patients with anticoagulation-related intracerebral hemorrhage","volume":"313","author":"Kuramatsu","year":"2015","journal-title":"JAMA"},{"issue":"3","key":"2023062806480154800_fcad159-B23","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/ana.25969","article-title":"Multicenter validation of the max-ICH score in intracerebral hemorrhage","volume":"89","author":"Sembill","year":"2021","journal-title":"Ann Neurol"},{"key":"2023062806480154800_fcad159-B24","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/eurheartj\/ehy056","article-title":"Management of therapeutic anticoagulation in patients with intracerebral haemorrhage and mechanical heart valves","volume":"39","author":"Kuramatsu","year":"2018","journal-title":"Eur Heart J"},{"issue":"1","key":"2023062806480154800_fcad159-B25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13195-018-0418-3","article-title":"Interlaboratory proficiency processing scheme in CSF aliquoting: Implementation and assessment based on biomarkers of Alzheimer\u2019s disease","volume":"10","author":"Lewczuk","year":"2018","journal-title":"Alzheimer\u2019s Res Ther"},{"issue":"2","key":"2023062806480154800_fcad159-B26","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3233\/JAD-160722","article-title":"Cerebrospinal fluid Abeta42\/40 corresponds better than Abeta42 to amyloid PET in Alzheimer\u2019s disease","volume":"55","author":"Lewczuk","year":"2016","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"23","key":"2023062806480154800_fcad159-B27","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1002\/sim.4509","article-title":"Classification accuracy and cut point selection","volume":"31","author":"Liu","year":"2012","journal-title":"Stat Med"},{"key":"2023062806480154800_fcad159-B28","first-page":"1532","article-title":"Scikit-learn: Machine learning in python","volume":"12","author":"Fabian Pedregosa","year":"2011","journal-title":"J Mach Learn Res"},{"issue":"60","key":"2023062806480154800_fcad159-B29","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.21105\/joss.03021","article-title":"Seaborn: Statistical data visualization","volume":"6","author":"Waskom","year":"2021","journal-title":"J Open Source Software"},{"issue":"4","key":"2023062806480154800_fcad159-B30","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1080\/15622975.2017.1375556","article-title":"Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the consensus of the task force on biological markers in psychiatry of the world federation of societies of biological psychiatry","volume":"19","author":"Lewczuk","year":"2018","journal-title":"World J Biol Psychiatry"},{"issue":"4","key":"2023062806480154800_fcad159-B31","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3233\/JAD-191254","article-title":"Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy","volume":"74","author":"Banerjee","year":"2020","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"8","key":"2023062806480154800_fcad159-B32","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1161\/STROKEAHA.116.012999","article-title":"Cerebral amyloid angiopathy is associated with executive dysfunction and mild cognitive impairment","volume":"47","author":"Case","year":"2016","journal-title":"Stroke"},{"issue":"1","key":"2023062806480154800_fcad159-B33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/jcbfm.2015.88","article-title":"Ischemic brain injury in cerebral amyloid angiopathy","volume":"36","author":"Reijmer","year":"2016","journal-title":"J Cerebral Blood Flow Metab"},{"issue":"3","key":"2023062806480154800_fcad159-B34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jalz.2010.03.002","article-title":"The Alzheimer's disease neuroimaging initiative: Annual change in biomarkers and clinical outcomes","volume":"6","author":"Beckett","year":"2010","journal-title":"Alzheimer\u2019s Dement"},{"issue":"9","key":"2023062806480154800_fcad159-B35","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1212\/WNL.0000000000003667","article-title":"Phenotype and neuroimaging in cerebral amyloid angiopathy: More blood","volume":"88","author":"McCarron","year":"2017","journal-title":"Neurology"},{"issue":"9","key":"2023062806480154800_fcad159-B36","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1212\/WNL.0000000000003655","article-title":"Small vessel disease burden in cerebral amyloid angiopathy without symptomatic hemorrhage","volume":"88","author":"Boulouis","year":"2017","journal-title":"Neurology"},{"issue":"5\u20136","key":"2023062806480154800_fcad159-B37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1159\/000381223","article-title":"The characteristics of superficial siderosis and convexity subarachnoid hemorrhage and clinical relevance in suspected cerebral amyloid angiopathy","volume":"39","author":"Ni","year":"2015","journal-title":"Cerebrovasc Dis"},{"issue":"9","key":"2023062806480154800_fcad159-B38","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1161\/STROKEAHA.112.657759","article-title":"Spectrum of transient focal neurological episodes in cerebral amyloid angiopathy: Multicentre magnetic resonance imaging cohort study and meta-analysis","volume":"43","author":"Charidimou","year":"2012","journal-title":"Stroke"},{"issue":"6","key":"2023062806480154800_fcad159-B39","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1161\/STROKEAHA.121.035836","article-title":"Prevalence of clinical and neuroimaging markers in cerebral amyloid angiopathy: A systematic review and meta-analysis","volume":"53","author":"Malhotra","year":"2022","journal-title":"Stroke"},{"issue":"2","key":"2023062806480154800_fcad159-B40","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/STROKEAHA.110.596122","article-title":"Microbleeds are independently related to gait disturbances in elderly individuals with cerebral small vessel disease","volume":"42","author":"de Laat","year":"2011","journal-title":"Stroke"},{"issue":"S6","key":"2023062806480154800_fcad159-B41","doi-asserted-by":"crossref","DOI":"10.1002\/alz.041325","article-title":"Gait impairments on single and dual tasks in cerebral amyloid angiopathy","volume":"16","author":"Sharma","year":"2020","journal-title":"Alzheimer\u2019s Dement"},{"key":"2023062806480154800_fcad159-B42","author":"Aduhelm"},{"issue":"8","key":"2023062806480154800_fcad159-B43","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S1474-4422(21)00213-1","article-title":"Off-label use of aducanumab for cerebral amyloid angiopathy","volume":"20","author":"Greenberg","year":"2021","journal-title":"Lancet Neurol"},{"issue":"3","key":"2023062806480154800_fcad159-B44","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s00401-005-1064-y","article-title":"Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy","volume":"110","author":"Attems","year":"2005","journal-title":"Acta Neuropathol"},{"issue":"7","key":"2023062806480154800_fcad159-B45","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1161\/STROKEAHA.108.536839","article-title":"Beta-amyloid, blood vessels, and brain function","volume":"40","author":"Smith","year":"2009","journal-title":"Stroke"},{"key":"2023062806480154800_fcad159-B46","doi-asserted-by":"crossref","first-page":"771\u2013","DOI":"10.1056\/NEJMp2111320","article-title":"Controversy and progress in Alzheimer\u2019s disease - FDA approval of aducanumab","volume":"385","author":"Rabinovici","year":"2021","journal-title":"N Engl J Med"},{"issue":"4","key":"2023062806480154800_fcad159-B47","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1212\/WNL.56.4.537","article-title":"Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston criteria","volume":"56","author":"Knudsen","year":"2001","journal-title":"Neurology"},{"issue":"17","key":"2023062806480154800_fcad159-B48","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1212\/WNL.0b013e3181dad605","article-title":"Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy","volume":"74","author":"Linn","year":"2010","journal-title":"Neurology"},{"issue":"12","key":"2023062806480154800_fcad159-B49","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jalz.2015.04.009","article-title":"Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage","volume":"11","author":"Martinez-Ramirez","year":"2015","journal-title":"Alzheimer\u2019s Dement"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcad159\/50408081\/fcad159.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/5\/3\/fcad159\/50729392\/fcad159.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/5\/3\/fcad159\/50729392\/fcad159.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T07:58:35Z","timestamp":1702454315000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcad159\/7174282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcad159","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023]]},"published":{"date-parts":[[2023]]},"article-number":"fcad159"}}