{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:58:21Z","timestamp":1791892701825,"version":"4.3.4"},"reference-count":173,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":256,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF-21- 48972"],"award-info":[{"award-number":["AARF-21- 48972"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30-AG072979"],"award-info":[{"award-number":["P30-AG072979"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1-AG069474"],"award-info":[{"award-number":["RF1-AG069474"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AG056014"],"award-info":[{"award-number":["R01-AG056014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AG055005"],"award-info":[{"award-number":["R01-AG055005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AG072796"],"award-info":[{"award-number":["R01-AG072796"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AG070592"],"award-info":[{"award-number":["R01-AG070592"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Functional disruption of the medial temporal lobe-dependent networks is thought to underlie episodic memory deficits in aging and Alzheimer\u2019s disease. Previous studies revealed that the anterior medial temporal lobe is more vulnerable to pathological and neurodegenerative processes in Alzheimer\u2019s disease. In contrast, cognitive and structural imaging literature indicates posterior, as opposed to anterior, medial temporal lobe vulnerability in normal aging. However, the extent to which Alzheimer\u2019s and aging-related pathological processes relate to functional disruption of the medial temporal lobe-dependent brain networks is poorly understood. To address this knowledge gap, we examined functional connectivity alterations in the medial temporal lobe and its immediate functional neighbourhood\u2014the Anterior-Temporal and Posterior-Medial brain networks\u2014in normal agers, individuals with preclinical Alzheimer\u2019s disease and patients with Mild Cognitive Impairment or mild dementia due to Alzheimer\u2019s disease. In the Anterior-Temporal network and in the perirhinal cortex, in particular, we observed an inverted \u2018U-shaped\u2019 relationship between functional connectivity and Alzheimer\u2019s stage. According to our results, the preclinical phase of Alzheimer\u2019s disease is characterized by increased functional connectivity between the perirhinal cortex and other regions of the medial temporal lobe, as well as between the anterior medial temporal lobe and its one-hop neighbours in the Anterior-Temporal system. This effect is no longer present in symptomatic Alzheimer\u2019s disease. Instead, patients with symptomatic Alzheimer\u2019s disease displayed reduced hippocampal connectivity within the medial temporal lobe as well as hypoconnectivity within the Posterior-Medial system. For normal aging, our results led to three main conclusions: (i) intra-network connectivity of both the Anterior-Temporal and Posterior-Medial networks declines with age; (ii) the anterior and posterior segments of the medial temporal lobe become increasingly decoupled from each other with advancing age; and (iii) the posterior subregions of the medial temporal lobe, especially the parahippocampal cortex, are more vulnerable to age-associated loss of function than their anterior counterparts. Together, the current results highlight evolving medial temporal lobe dysfunction in Alzheimer\u2019s disease and indicate different neurobiological mechanisms of the medial temporal lobe network disruption in aging versus Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad245","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T21:50:26Z","timestamp":1694728226000},"source":"Crossref","is-referenced-by-count":30,"title":["Aging and Alzheimer\u2019s disease have dissociable effects on local and regional medial temporal lobe connectivity"],"prefix":"10.1093","volume":"5","author":[{"given":"Stanislau","family":"Hrybouski","sequence":"first","affiliation":[{"name":"Penn Image Computing and Science Laboratory (PICSL), University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Department of Radiology, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhitsu R","family":"Das","sequence":"additional","affiliation":[{"name":"Penn Image Computing and Science Laboratory (PICSL), University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Department of Neurology, University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Penn Memory Center, University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Penn Alzheimer\u2019s Disease Research Center, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Xie","sequence":"additional","affiliation":[{"name":"Penn Image Computing and Science Laboratory (PICSL), University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Department of Radiology, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E M","family":"Wisse","sequence":"additional","affiliation":[{"name":"Penn Image Computing and Science Laboratory (PICSL), University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Department of Radiology, University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Department of Diagnostic Radiology, Lund University , 221 00 Lund , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Kelley","sequence":"additional","affiliation":[{"name":"Penn Memory Center, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Lane","sequence":"additional","affiliation":[{"name":"Penn Memory Center, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Sherin","sequence":"additional","affiliation":[{"name":"Penn Memory Center, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"DiCalogero","sequence":"additional","affiliation":[{"name":"Penn Memory Center, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Nasrallah","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Penn Alzheimer\u2019s Disease Research Center, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Detre","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Department of Neurology, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8543-4016","authenticated-orcid":false,"given":"Paul A","family":"Yushkevich","sequence":"additional","affiliation":[{"name":"Penn Image Computing and Science Laboratory (PICSL), University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Department of Radiology, University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Penn Alzheimer\u2019s Disease Research Center, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Wolk","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania , Philadelphia, PA 19104 , USA"},{"name":"Penn Alzheimer\u2019s Disease Research Center, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"issue":"1","key":"2023092615572775800_fcad245-B1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/(SICI)1098-1063(1999)9:1<83::AID-HIPO9>3.0.CO;2-7","article-title":"Hippocampal system and declarative (relational) memory: Summarizing the data from functional neuroimaging studies","volume":"9","author":"Cohen","year":"1999","journal-title":"Hippocampus"},{"key":"2023092615572775800_fcad245-B2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuroimage.2016.02.056","article-title":"Amygdala subnuclei response and connectivity during emotional processing","volume":"133","author":"Hrybouski","year":"2016","journal-title":"Neuroimage"},{"issue":"2","key":"2023092615572775800_fcad245-B3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/1754073908100432","article-title":"Remembering the details: Effects of emotion","volume":"1","author":"Kensinger","year":"2009","journal-title":"Emot Rev"},{"issue":"11","key":"2023092615572775800_fcad245-B4","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/nn.4661","article-title":"Viewpoints: How the hippocampus contributes to memory, navigation and cognition","volume":"20","author":"Lisman","year":"2017","journal-title":"Nat Neurosci"},{"key":"2023092615572775800_fcad245-B5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev-psych-113011-143733","article-title":"Episodic memory and beyond: The hippocampus and neocortex in transformation","volume":"67","author":"Moscovitch","year":"2016","journal-title":"Annu Rev Psychol"},{"issue":"10","key":"2023092615572775800_fcad245-B6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrn3338","article-title":"Two cortical systems for memory-guided behaviour","volume":"13","author":"Ranganath","year":"2012","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"2023092615572775800_fcad245-B7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.tics.2013.03.005","article-title":"Long-axis specialization of the human hippocampus","volume":"17","author":"Poppenk","year":"2013","journal-title":"Trends Cogn Sci"},{"issue":"8","key":"2023092615572775800_fcad245-B8","doi-asserted-by":"crossref","first-page":"a021766","DOI":"10.1101\/cshperspect.a021766","article-title":"Memory consolidation","volume":"7","author":"Squire","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"2023092615572775800_fcad245-B9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1101\/lm.024018.111","article-title":"Working memory, long-term memory, and medial temporal lobe function","volume":"19","author":"Jeneson","year":"2012","journal-title":"Learn Mem"},{"key":"2023092615572775800_fcad245-B10","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.neuroimage.2019.01.061","article-title":"Involvement of hippocampal subfields and anterior-posterior subregions in encoding and retrieval of item, spatial, and associative memories: Longitudinal versus transverse axis","volume":"191","author":"Hrybouski","year":"2019","journal-title":"Neuroimage"},{"issue":"11","key":"2023092615572775800_fcad245-B11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41583-018-0067-3","article-title":"Imaging the evolution and pathophysiology of Alzheimer disease","volume":"19","author":"Jagust","year":"2018","journal-title":"Nat Rev Neurosci"},{"key":"2023092615572775800_fcad245-B12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1101\/sqb.2018.83.036889","article-title":"A network explanation of Alzheimer's regional vulnerability","volume":"83","author":"Small","year":"2018","journal-title":"Cold Spring Harb Symp Quant Biol"},{"issue":"10","key":"2023092615572775800_fcad245-B13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrn3085","article-title":"A pathophysiological framework of hippocampal dysfunction in ageing and disease","volume":"12","author":"Small","year":"2011","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"2023092615572775800_fcad245-B14","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nn.3631","article-title":"Ground zero in Alzheimer's disease","volume":"17","author":"Yassa","year":"2014","journal-title":"Nat Neurosci"},{"issue":"12","key":"2023092615572775800_fcad245-B15","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.tins.2021.10.003","article-title":"The many dimensions of human hippocampal organization and (dys)function","volume":"44","author":"Genon","year":"2021","journal-title":"Trends Neurosci"},{"issue":"4","key":"2023092615572775800_fcad245-B16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol"},{"issue":"4","key":"2023092615572775800_fcad245-B17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"2023092615572775800_fcad245-B18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neurobiolaging.2017.08.001","article-title":"Differential vulnerability of hippocampal subfields and anteroposterior hippocampal subregions in healthy cognitive aging","volume":"59","author":"Malykhin","year":"2017","journal-title":"Neurobiol Aging"},{"issue":"16","key":"2023092615572775800_fcad245-B19","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1002\/hbm.25151","article-title":"Longitudinal atrophy in early Braak regions in preclinical Alzheimer's disease","volume":"41","author":"Xie","year":"2020","journal-title":"Hum Brain Mapp"},{"issue":"9","key":"2023092615572775800_fcad245-B20","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1093\/brain\/awab262","article-title":"Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe","volume":"144","author":"Yushkevich","year":"2021","journal-title":"Brain"},{"issue":"16","key":"2023092615572775800_fcad245-B21","doi-asserted-by":"crossref","first-page":"E2093","DOI":"10.1073\/pnas.1504394112","article-title":"Architecture of the cerebral cortical association connectome underlying cognition","volume":"112","author":"Bota","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"2023092615572775800_fcad245-B22","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1093\/brain\/awaa068","article-title":"Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease","volume":"143","author":"Berron","year":"2020","journal-title":"Brain"},{"issue":"Suppl 1)","key":"2023092615572775800_fcad245-B23","doi-asserted-by":"crossref","first-page":"S141","DOI":"10.1016\/j.neurobiolaging.2014.03.041","article-title":"Anterior and posterior MTL networks in aging and MCI","volume":"36","author":"Das","year":"2015","journal-title":"Neurobiol Aging"},{"issue":"10","key":"2023092615572775800_fcad245-B24","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1523\/JNEUROSCI.0949-21.2021","article-title":"Medial temporal lobe networks in Alzheimer's disease: Structural and molecular vulnerabilities","volume":"42","author":"de Flores","year":"2022","journal-title":"J Neurosci"},{"issue":"19","key":"2023092615572775800_fcad245-B25","doi-asserted-by":"crossref","first-page":"6550","DOI":"10.1523\/JNEUROSCI.3711-11.2012","article-title":"Differential connectivity of perirhinal and parahippocampal cortices within human hippocampal subregions revealed by high-resolution functional imaging","volume":"32","author":"Libby","year":"2012","journal-title":"J Neurosci"},{"issue":"6","key":"2023092615572775800_fcad245-B26","doi-asserted-by":"crossref","first-page":"e3001275","DOI":"10.1371\/journal.pbio.3001275","article-title":"Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain","volume":"19","author":"Barnett","year":"2021","journal-title":"PLoS Biol"},{"key":"2023092615572775800_fcad245-B27","doi-asserted-by":"crossref","first-page":"e06426","DOI":"10.7554\/eLife.06426","article-title":"Functional subregions of the human entorhinal cortex","volume":"4","author":"Maass","year":"2015","journal-title":"Elife"},{"issue":"8","key":"2023092615572775800_fcad245-B28","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1093\/brain\/awz154","article-title":"Alzheimer's pathology targets distinct memory networks in the ageing brain","volume":"142","author":"Maass","year":"2019","journal-title":"Brain"},{"key":"2023092615572775800_fcad245-B29","doi-asserted-by":"crossref","first-page":"e49132","DOI":"10.7554\/eLife.49132","article-title":"Cortical tau deposition follows patterns of entorhinal functional connectivity in aging","volume":"8","author":"Adams","year":"2019","journal-title":"Elife"},{"issue":"1","key":"2023092615572775800_fcad245-B30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41398-022-02024-7","article-title":"Neuronal hyperexcitability in Alzheimer's disease: What are the drivers behind this aberrant phenotype?","volume":"12","author":"Targa Dias Anastacio","year":"2022","journal-title":"Transl Psychiatry"},{"issue":"7","key":"2023092615572775800_fcad245-B31","doi-asserted-by":"crossref","first-page":"a006338","DOI":"10.1101\/cshperspect.a006338","article-title":"Neurotoxicity of amyloid beta-protein: Synaptic and network dysfunction","volume":"2","author":"Mucke","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"12","key":"2023092615572775800_fcad245-B32","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrn.2016.141","article-title":"Network abnormalities and interneuron dysfunction in Alzheimer disease","volume":"17","author":"Palop","year":"2016","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"2023092615572775800_fcad245-B33","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuron.2014.10.038","article-title":"The evolution of preclinical Alzheimer's disease: Implications for prevention trials","volume":"84","author":"Sperling","year":"2014","journal-title":"Neuron"},{"issue":"7","key":"2023092615572775800_fcad245-B34","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.neuropsychologia.2003.11.015","article-title":"Hippocampal adaptation to face repetition in healthy elderly and mild cognitive impairment","volume":"42","author":"Johnson","year":"2004","journal-title":"Neuropsychologia"},{"issue":"12","key":"2023092615572775800_fcad245-B35","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/j.neurobiolaging.2006.08.008","article-title":"Increased fMRI responses during encoding in mild cognitive impairment","volume":"28","author":"H\u00e4m\u00e4l\u00e4inen","year":"2007","journal-title":"Neurobiol Aging"},{"issue":"8","key":"2023092615572775800_fcad245-B36","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1136\/jnnp.2006.104877","article-title":"Hippocampal activation in patients with mild cognitive impairment is necessary for successful memory encoding","volume":"78","author":"Kircher","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"Pt 4","key":"2023092615572775800_fcad245-B37","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1093\/brain\/awv007","article-title":"Amyloid-beta deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression","volume":"138","author":"Huijbers","year":"2015","journal-title":"Brain"},{"issue":"3","key":"2023092615572775800_fcad245-B38","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.neuroimage.2010.03.040","article-title":"High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment","volume":"51","author":"Yassa","year":"2010","journal-title":"Neuroimage"},{"issue":"7","key":"2023092615572775800_fcad245-B39","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1056\/NEJM200008173430701","article-title":"Patterns of brain activation in people at risk for Alzheimer's disease","volume":"343","author":"Bookheimer","year":"2000","journal-title":"N Engl J Med"},{"key":"2023092615572775800_fcad245-B40","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.nicl.2016.12.002","article-title":"Increased hippocampal activation in ApoE-4 carriers and non-carriers with amnestic mild cognitive impairment","volume":"13","author":"Tran","year":"2017","journal-title":"Neuroimage Clin"},{"issue":"22","key":"2023092615572775800_fcad245-B41","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1523\/JNEUROSCI.0959-06.2006","article-title":"The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation","volume":"26","author":"Johnson","year":"2006","journal-title":"J Neurosci"},{"issue":"17","key":"2023092615572775800_fcad245-B42","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1073\/pnas.0811879106","article-title":"Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele","volume":"106","author":"Filippini","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"2023092615572775800_fcad245-B43","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/ana.22105","article-title":"Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease","volume":"68","author":"Quiroz","year":"2010","journal-title":"Ann Neurol"},{"issue":"12","key":"2023092615572775800_fcad245-B44","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1474-4422(12)70228-4","article-title":"Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: A case-control study","volume":"11","author":"Reiman","year":"2012","journal-title":"Lancet Neurol"},{"issue":"17","key":"2023092615572775800_fcad245-B45","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1523\/JNEUROSCI.2504-20.2021","article-title":"Reduced repetition suppression in aging is driven by tau-related hyperactivity in medial temporal lobe","volume":"41","author":"Adams","year":"2021","journal-title":"J Neurosci"},{"issue":"1","key":"2023092615572775800_fcad245-B46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hipo.22051","article-title":"Increased functional connectivity within medial temporal lobe in mild cognitive impairment","volume":"23","author":"Das","year":"2013","journal-title":"Hippocampus"},{"issue":"4","key":"2023092615572775800_fcad245-B47","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3233\/JAD-150727","article-title":"Impaired parahippocampus connectivity in mild cognitive impairment and Alzheimer's disease","volume":"49","author":"Liu","year":"2016","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"2023092615572775800_fcad245-B48","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jalz.2014.02.007","article-title":"Link between hippocampus\u2019 raised local and eased global intrinsic connectivity in AD","volume":"11","author":"Pasquini","year":"2015","journal-title":"Alzheimers Dement"},{"issue":"7","key":"2023092615572775800_fcad245-B49","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1523\/JNEUROSCI.2092-14.2015","article-title":"Brain amyloid-beta burden is associated with disruption of intrinsic functional connectivity within the medial temporal lobe in cognitively normal elderly","volume":"35","author":"Song","year":"2015","journal-title":"J Neurosci"},{"key":"2023092615572775800_fcad245-B50","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.neuroimage.2014.08.003","article-title":"Characteristics of the default mode functional connectivity in normal ageing and Alzheimer's disease using resting state fMRI with a combined approach of entropy-based and graph theoretical measurements","volume":"101","author":"Toussaint","year":"2014","journal-title":"Neuroimage"},{"issue":"12","key":"2023092615572775800_fcad245-B51","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/nn.2433","article-title":"Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses","volume":"12","author":"Abramov","year":"2009","journal-title":"Nat Neurosci"},{"key":"2023092615572775800_fcad245-B52","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.nbd.2017.08.015","article-title":"Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit","volume":"108","author":"Angulo","year":"2017","journal-title":"Neurobiol Dis"},{"issue":"1700","key":"2023092615572775800_fcad245-B53","doi-asserted-by":"crossref","first-page":"20150429","DOI":"10.1098\/rstb.2015.0429","article-title":"Impairments of neural circuit function in Alzheimer's disease","volume":"371","author":"Busche","year":"2016","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"5","key":"2023092615572775800_fcad245-B54","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.celrep.2014.04.024","article-title":"APP Homodimers transduce an amyloid-beta-mediated increase in release probability at excitatory synapses","volume":"7","author":"Fogel","year":"2014","journal-title":"Cell Rep"},{"issue":"5","key":"2023092615572775800_fcad245-B55","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease","volume":"55","author":"Palop","year":"2007","journal-title":"Neuron"},{"issue":"6","key":"2023092615572775800_fcad245-B56","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.celrep.2015.04.017","article-title":"Chronic optogenetic activation augments abeta pathology in a mouse model of Alzheimer disease","volume":"11","author":"Yamamoto","year":"2015","journal-title":"Cell Rep"},{"issue":"6453","key":"2023092615572775800_fcad245-B57","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.aay0198","article-title":"A vicious cycle of beta amyloid-dependent neuronal hyperactivation","volume":"365","author":"Zott","year":"2019","journal-title":"Science"},{"issue":"8","key":"2023092615572775800_fcad245-B58","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/nn.4328","article-title":"Neuronal activity enhances tau propagation and tau pathology in vivo","volume":"19","author":"Wu","year":"2016","journal-title":"Nat Neurosci"},{"issue":"2","key":"2023092615572775800_fcad245-B59","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nn.3606","article-title":"Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease","volume":"17","author":"Khan","year":"2014","journal-title":"Nat Neurosci"},{"issue":"9","key":"2023092615572775800_fcad245-B60","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1001\/archneur.58.9.1395","article-title":"Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease","volume":"58","author":"Price","year":"2001","journal-title":"Arch Neurol"},{"issue":"14","key":"2023092615572775800_fcad245-B61","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1523\/JNEUROSCI.16-14-04491.1996","article-title":"Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease","volume":"16","author":"Gomez-Isla","year":"1996","journal-title":"J Neurosci"},{"issue":"5594","key":"2023092615572775800_fcad245-B62","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","article-title":"Alzheimer's disease is a synaptic failure","volume":"298","author":"Selkoe","year":"2002","journal-title":"Science"},{"issue":"12","key":"2023092615572775800_fcad245-B63","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1016\/j.neurobiolaging.2015.08.020","article-title":"Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging","volume":"36","author":"Fjell","year":"2015","journal-title":"Neurobiol Aging"},{"key":"2023092615572775800_fcad245-B64","doi-asserted-by":"crossref","first-page":"1002096","DOI":"10.3389\/fnagi.2022.1002096","article-title":"25 Years of neurocognitive aging theories: What have we learned?","volume":"14","author":"McDonough","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"7","key":"2023092615572775800_fcad245-B65","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.tics.2019.04.012","article-title":"Neural dedifferentiation in the aging brain","volume":"23","author":"Koen","year":"2019","journal-title":"Trends Cogn Sci"},{"key":"2023092615572775800_fcad245-B66","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fnsys.2011.00002","article-title":"A baseline for the multivariate comparison of resting-state networks","volume":"5","author":"Allen","year":"2011","journal-title":"Front Syst Neurosci"},{"issue":"4","key":"2023092615572775800_fcad245-B67","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s00429-021-02226-7","article-title":"Investigating the effects of healthy cognitive aging on brain functional connectivity using 4.7 T resting-state functional magnetic resonance imaging","volume":"226","author":"Hrybouski","year":"2021","journal-title":"Brain Struct Funct"},{"issue":"5","key":"2023092615572775800_fcad245-B68","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.neuron.2007.10.038","article-title":"Disruption of large-scale brain systems in advanced aging","volume":"56","author":"Andrews-Hanna","year":"2007","journal-title":"Neuron"},{"issue":"Pt 2","key":"2023092615572775800_fcad245-B69","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuroimage.2014.07.067","article-title":"Changes in structural and functional connectivity among resting-state networks across the human lifespan","volume":"102","author":"Betzel","year":"2014","journal-title":"Neuroimage"},{"issue":"1","key":"2023092615572775800_fcad245-B70","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/09658211.2014.985590","article-title":"Recollection, not familiarity, decreases in healthy ageing: Converging evidence from four estimation methods","volume":"24","author":"Koen","year":"2016","journal-title":"Memory"},{"issue":"6","key":"2023092615572775800_fcad245-B71","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neuropsychologia.2013.02.014","article-title":"Familiarity-based memory as an early cognitive marker of preclinical and prodromal AD","volume":"51","author":"Wolk","year":"2013","journal-title":"Neuropsychologia"},{"issue":"8","key":"2023092615572775800_fcad245-B72","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1037\/pag0000635","article-title":"Verbatim and gist memory in aging","volume":"36","author":"Abadie","year":"2021","journal-title":"Psychol Aging"},{"issue":"8","key":"2023092615572775800_fcad245-B73","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1080\/09658211.2020.1813781","article-title":"The effect of age on recollection is not moderated by differential estimation methods","volume":"28","author":"Alghamdi","year":"2020","journal-title":"Memory"},{"issue":"1","key":"2023092615572775800_fcad245-B74","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijpsycho.2008.07.005","article-title":"Episodic memory decay along the adult lifespan: A review of behavioral and neurophysiological evidence","volume":"71","author":"Cansino","year":"2009","journal-title":"Int J Psychophysiol"},{"issue":"1","key":"2023092615572775800_fcad245-B75","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/WAD.0000000000000223","article-title":"Version 3 of the Alzheimer Disease Centers\u2019 Neuropsychological Test Battery in the Uniform Data Set (UDS)","volume":"32","author":"Weintraub","year":"2018","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"4","key":"2023092615572775800_fcad245-B76","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal cognitive assessment, MoCA: A brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"2023092615572775800_fcad245-B77","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41592-018-0235-4","article-title":"fMRIPrep: A robust preprocessing pipeline for functional MRI","volume":"16","author":"Esteban","year":"2019","journal-title":"Nat Methods"},{"issue":"2","key":"2023092615572775800_fcad245-B78","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"issue":"Suppl 1)","key":"2023092615572775800_fcad245-B79","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"issue":"1","key":"2023092615572775800_fcad245-B80","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/mrm.1910340111","article-title":"Correction for geometric distortion in echo planar images from B0 field variations","volume":"34","author":"Jezzard","year":"1995","journal-title":"Magn Reson Med"},{"issue":"1","key":"2023092615572775800_fcad245-B81","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuroimage.2009.06.060","article-title":"Accurate and robust brain image alignment using boundary-based registration","volume":"48","author":"Greve","year":"2009","journal-title":"Neuroimage"},{"issue":"Suppl 1","key":"2023092615572775800_fcad245-B82","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1016\/j.neuroimage.2004.07.010","article-title":"Geodesic estimation for large deformation anatomical shape averaging and interpolation","volume":"23","author":"Avants","year":"2004","journal-title":"Neuroimage"},{"issue":"1","key":"2023092615572775800_fcad245-B83","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain","volume":"12","author":"Avants","year":"2008","journal-title":"Med Image Anal"},{"issue":"2","key":"2023092615572775800_fcad245-B84","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1109\/TMI.2003.822821","article-title":"Probabilistic independent component analysis for functional magnetic resonance imaging","volume":"23","author":"Beckmann","year":"2004","journal-title":"IEEE Trans Med Imaging"},{"key":"2023092615572775800_fcad245-B85","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroimage.2015.02.064","article-title":"ICA-AROMA: A robust ICA-based strategy for removing motion artifacts from fMRI data","volume":"112","author":"Pruim","year":"2015","journal-title":"Neuroimage"},{"key":"2023092615572775800_fcad245-B86","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neuroimage.2016.12.036","article-title":"Hand classification of fMRI ICA noise components","volume":"154","author":"Griffanti","year":"2017","journal-title":"Neuroimage"},{"key":"2023092615572775800_fcad245-B87","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neuroimage.2014.03.034","article-title":"ICA-based artefact removal and accelerated fMRI acquisition for improved resting state network imaging","volume":"95","author":"Griffanti","year":"2014","journal-title":"Neuroimage"},{"issue":"3","key":"2023092615572775800_fcad245-B88","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: A functional connectivity toolbox for correlated and anticorrelated brain networks","volume":"2","author":"Whitfield-Gabrieli","year":"2012","journal-title":"Brain Connect"},{"issue":"3","key":"2023092615572775800_fcad245-B89","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neuroimage.2008.09.036","article-title":"The impact of global signal regression on resting state correlations: Are anti-correlated networks introduced?","volume":"44","author":"Murphy","year":"2009","journal-title":"Neuroimage"},{"issue":"1","key":"2023092615572775800_fcad245-B90","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/brain.2012.0080","article-title":"Trouble at rest: How correlation patterns and group differences become distorted after global signal regression","volume":"2","author":"Saad","year":"2012","journal-title":"Brain Connect"},{"issue":"4","key":"2023092615572775800_fcad245-B91","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.neuroimage.2009.05.005","article-title":"Correlations and anticorrelations in resting-state functional connectivity MRI: A quantitative comparison of preprocessing strategies","volume":"47","author":"Weissenbacher","year":"2009","journal-title":"Neuroimage"},{"issue":"1","key":"2023092615572775800_fcad245-B92","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuroimage.2007.04.042","article-title":"A component based noise correction method (CompCor) for BOLD and perfusion based fMRI","volume":"37","author":"Behzadi","year":"2007","journal-title":"Neuroimage"},{"issue":"3","key":"2023092615572775800_fcad245-B93","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/mrm.1910350312","article-title":"Movement-related effects in fMRI time-series","volume":"35","author":"Friston","year":"1996","journal-title":"Magn Reson Med"},{"key":"2023092615572775800_fcad245-B94","doi-asserted-by":"crossref","first-page":"116866","DOI":"10.1016\/j.neuroimage.2020.116866","article-title":"Removal of high frequency contamination from motion estimates in single-band fMRI saves data without biasing functional connectivity","volume":"217","author":"Gratton","year":"2020","journal-title":"Neuroimage"},{"key":"2023092615572775800_fcad245-B95","doi-asserted-by":"crossref","first-page":"116400","DOI":"10.1016\/j.neuroimage.2019.116400","article-title":"Correction of respiratory artifacts in MRI head motion estimates","volume":"208","author":"Fair","year":"2020","journal-title":"Neuroimage"},{"issue":"12","key":"2023092615572775800_fcad245-B96","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1002\/hbm.24607","article-title":"Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease","volume":"40","author":"Xie","year":"2019","journal-title":"Hum Brain Mapp"},{"issue":"6","key":"2023092615572775800_fcad245-B97","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nmeth.2482","article-title":"Imaging human connectomes at the macroscale","volume":"10","author":"Craddock","year":"2013","journal-title":"Nat Methods"},{"issue":"2","key":"2023092615572775800_fcad245-B98","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.neuroimage.2010.08.063","article-title":"Network modelling methods for FMRI","volume":"54","author":"Smith","year":"2011","journal-title":"Neuroimage"},{"issue":"4","key":"2023092615572775800_fcad245-B99","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1162\/netn_a_00166","article-title":"Revisiting correlation-based functional connectivity and its relationship with structural connectivity","volume":"4","author":"Li\u00e9geois","year":"2020","journal-title":"Netw Neurosci"},{"issue":"4","key":"2023092615572775800_fcad245-B100","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.neuroimage.2010.06.041","article-title":"Network-based statistic: Identifying differences in brain networks","volume":"53","author":"Zalesky","year":"2010","journal-title":"Neuroimage"},{"issue":"4","key":"2023092615572775800_fcad245-B101","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1080\/07350015.1983.10509354","article-title":"A nonstochastic interpretation of reported significance levels","volume":"1","author":"Freedman","year":"1983","journal-title":"J Bus Econ Stat"},{"issue":"1","key":"2023092615572775800_fcad245-B102","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B (Methodol)"},{"key":"2023092615572775800_fcad245-B103","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neuroimage.2013.08.048","article-title":"Methods to detect, characterize, and remove motion artifact in resting state fMRI","volume":"84","author":"Power","year":"2014","journal-title":"Neuroimage"},{"issue":"2","key":"2023092615572775800_fcad245-B104","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pscychresns.2006.11.011","article-title":"Three-dimensional volumetric analysis and reconstruction of amygdala and hippocampal head, body and tail","volume":"155","author":"Malykhin","year":"2007","journal-title":"Psychiatry Res"},{"issue":"9","key":"2023092615572775800_fcad245-B105","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1093\/cercor\/bhx179","article-title":"Local-global parcellation of the human cerebral cortex from intrinsic functional connectivity MRI","volume":"28","author":"Schaefer","year":"2018","journal-title":"Cereb Cortex"},{"issue":"3","key":"2023092615572775800_fcad245-B106","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/biostatistics\/kxm045","article-title":"Sparse inverse covariance estimation with the graphical lasso","volume":"9","author":"Friedman","year":"2008","journal-title":"Biostatistics"},{"issue":"456","key":"2023092615572775800_fcad245-B107","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1198\/016214501753382273","article-title":"Variable selection via nonconcave penalized likelihood and its Oracle properties","volume":"96","author":"Fan","year":"2001","journal-title":"J Am Stat Assoc"},{"issue":"2","key":"2023092615572775800_fcad245-B108","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1214\/08-AOAS215","article-title":"Network exploration via the adaptive LASSO and SCAD penalties","volume":"3","author":"Fan","year":"2009","journal-title":"Ann Appl Stat"},{"issue":"3","key":"2023092615572775800_fcad245-B109","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1089\/brain.2017.0511","article-title":"Sparse graphical models for functional connectivity networks: Best methods and the autocorrelation issue","volume":"8","author":"Zhu","year":"2018","journal-title":"Brain Connect"},{"key":"2023092615572775800_fcad245-B110","first-page":"2911","article-title":"QUIC: Quadratic approximation for sparse inverse covariance estimation","volume":"15","author":"Hsieh","year":"2014","journal-title":"J Mach Learn Res"},{"issue":"10","key":"2023092615572775800_fcad245-B111","doi-asserted-by":"crossref","first-page":"P10008","DOI":"10.1088\/1742-5468\/2008\/10\/P10008","article-title":"Fast unfolding of communities in large networks","volume":"2008","author":"Blondel","year":"2008","journal-title":"J Stat Mech Theory Exp"},{"issue":"4","key":"2023092615572775800_fcad245-B112","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/j.neuroimage.2011.03.069","article-title":"Weight-conserving characterization of complex functional brain networks","volume":"56","author":"Rubinov","year":"2011","journal-title":"Neuroimage"},{"issue":"2","key":"2023092615572775800_fcad245-B113","doi-asserted-by":"crossref","first-page":"28004","DOI":"10.1209\/0295-5075\/86\/28004","article-title":"Improved community structure detection using a modified fine-tuning strategy","volume":"86","author":"Sun","year":"2009","journal-title":"Europhysics Lett"},{"key":"2023092615572775800_fcad245-B114","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/srep00336","article-title":"Consensus clustering in complex networks","volume":"2","author":"Lancichinetti","year":"2012","journal-title":"Sci Rep"},{"issue":"3","key":"2023092615572775800_fcad245-B115","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: Uses and interpretations","volume":"52","author":"Rubinov","year":"2010","journal-title":"Neuroimage"},{"issue":"7","key":"2023092615572775800_fcad245-B116","doi-asserted-by":"crossref","first-page":"e68910","DOI":"10.1371\/journal.pone.0068910","article-title":"Brainnet viewer: A network visualization tool for human brain connectomics","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"2023092615572775800_fcad245-B117","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuroimage.2011.05.090","article-title":"Basal functional connectivity within the anterior temporal network is associated with performance on declarative memory tasks","volume":"58","author":"Gour","year":"2011","journal-title":"Neuroimage"},{"issue":"16","key":"2023092615572775800_fcad245-B118","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1523\/JNEUROSCI.3263-16.2017","article-title":"Phases of hyperconnectivity and hypoconnectivity in the default mode and salience networks track with amyloid and tau in clinically normal individuals","volume":"37","author":"Schultz","year":"2017","journal-title":"J Neurosci"},{"issue":"1","key":"2023092615572775800_fcad245-B119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2014.08.014","article-title":"Storm before the quiet: Neuronal hyperactivity and abeta in the presymptomatic stages of Alzheimer's disease","volume":"36","author":"Stargardt","year":"2015","journal-title":"Neurobiol Aging"},{"issue":"4","key":"2023092615572775800_fcad245-B120","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1474-4422(17)30044-3","article-title":"Epileptic activity in Alzheimer's disease: Causes and clinical relevance","volume":"16","author":"Vossel","year":"2017","journal-title":"Lancet Neurol"},{"issue":"2","key":"2023092615572775800_fcad245-B121","doi-asserted-by":"crossref","first-page":"ENEURO.0418-20.2020","DOI":"10.1523\/ENEURO.0418-20.2020","article-title":"Neuronal network excitability in Alzheimer's disease: The puzzle of similar versus divergent roles of amyloid beta and tau","volume":"8","author":"Kazim","year":"2021","journal-title":"eNeuro"},{"issue":"9","key":"2023092615572775800_fcad245-B122","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1001\/jamaneurol.2013.136","article-title":"Seizures and epileptiform activity in the early stages of Alzheimer disease","volume":"70","author":"Vossel","year":"2013","journal-title":"JAMA Neurol"},{"issue":"3","key":"2023092615572775800_fcad245-B123","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.neuron.2012.03.023","article-title":"Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment","volume":"74","author":"Bakker","year":"2012","journal-title":"Neuron"},{"issue":"1","key":"2023092615572775800_fcad245-B124","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1038\/s41467-019-12921-z","article-title":"Tau deposition is associated with functional isolation of the hippocampus in aging","volume":"10","author":"Harrison","year":"2019","journal-title":"Nat Commun"},{"issue":"5896","key":"2023092615572775800_fcad245-B125","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1126\/science.1162844","article-title":"Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease","volume":"321","author":"Busche","year":"2008","journal-title":"Science"},{"issue":"4","key":"2023092615572775800_fcad245-B126","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/embor.2013.15","article-title":"Physiological release of endogenous tau is stimulated by neuronal activity","volume":"14","author":"Pooler","year":"2013","journal-title":"EMBO Rep"},{"issue":"22","key":"2023092615572775800_fcad245-B127","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1073\/pnas.1206171109","article-title":"Critical role of soluble amyloid-beta for early hippocampal hyperactivity in a mouse model of Alzheimer's disease","volume":"109","author":"Busche","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"2023092615572775800_fcad245-B128","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s43587-022-00204-0","article-title":"Biomarker modeling of Alzheimer\u2019s disease using PET-based braak staging","volume":"2","author":"Therriault","year":"2022","journal-title":"Nature Aging"},{"issue":"6","key":"2023092615572775800_fcad245-B129","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1212\/WNL.52.6.1158","article-title":"The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease","volume":"52","author":"Delacourte","year":"1999","journal-title":"Neurology"},{"issue":"3","key":"2023092615572775800_fcad245-B130","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1001\/jamaneurol.2013.1453","article-title":"Mechanisms of protein seeding in neurodegenerative diseases","volume":"70","author":"Walker","year":"2013","journal-title":"JAMA Neurol"},{"issue":"3","key":"2023092615572775800_fcad245-B131","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1074\/jbc.M112.394528","article-title":"Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons","volume":"288","author":"Wu","year":"2013","journal-title":"J Biol Chem"},{"issue":"9","key":"2023092615572775800_fcad245-B132","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1093\/brain\/awab114","article-title":"Early stages of tau pathology and its associations with functional connectivity, atrophy and memory","volume":"144","author":"Berron","year":"2021","journal-title":"Brain"},{"key":"2023092615572775800_fcad245-B133","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbr.2017.06.049","article-title":"Age-related deficits in the mnemonic similarity task for objects and scenes","volume":"333","author":"Stark","year":"2017","journal-title":"Behav Brain Res"},{"issue":"5","key":"2023092615572775800_fcad245-B134","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/hipo.23164","article-title":"Meta-analytic and functional connectivity evidence from functional magnetic resonance imaging for an anterior to posterior gradient of function along the hippocampal axis","volume":"30","author":"Grady","year":"2020","journal-title":"Hippocampus"},{"issue":"10","key":"2023092615572775800_fcad245-B135","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/hipo.23377","article-title":"Age-related functional connectivity along the hippocampal longitudinal axis","volume":"31","author":"Panitz","year":"2021","journal-title":"Hippocampus"},{"key":"2023092615572775800_fcad245-B136","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neurobiolaging.2021.09.010","article-title":"Regional age-related atrophy after screening for preclinical Alzheimer disease","volume":"109","author":"Koenig","year":"2022","journal-title":"Neurobiol Aging"},{"issue":"2","key":"2023092615572775800_fcad245-B137","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.neuroimage.2010.03.020","article-title":"Trajectories of brain aging in middle-aged and older adults: Regional and individual differences","volume":"51","author":"Raz","year":"2010","journal-title":"Neuroimage"},{"issue":"Pt 12","key":"2023092615572775800_fcad245-B138","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1093\/brain\/awn280","article-title":"Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla","volume":"131","author":"Frisoni","year":"2008","journal-title":"Brain"},{"issue":"1","key":"2023092615572775800_fcad245-B139","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/hipo.23259","article-title":"Age-related alterations in functional connectivity along the longitudinal axis of the hippocampus and its subfields","volume":"31","author":"Stark","year":"2021","journal-title":"Hippocampus"},{"key":"2023092615572775800_fcad245-B140","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.neuroimage.2016.03.047","article-title":"Differential effect of age on posterior and anterior hippocampal functional connectivity","volume":"133","author":"Damoiseaux","year":"2016","journal-title":"Neuroimage"},{"issue":"3","key":"2023092615572775800_fcad245-B141","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1006\/nimg.2002.1280","article-title":"Aging gracefully: Compensatory brain activity in high-performing older adults","volume":"17","author":"Cabeza","year":"2002","journal-title":"Neuroimage"},{"issue":"3 Pt 2","key":"2023092615572775800_fcad245-B142","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1523\/JNEUROSCI.14-03-01450.1994","article-title":"Age-related changes in cortical blood flow activation during visual processing of faces and location","volume":"14","author":"Grady","year":"1994","journal-title":"J Neurosci"},{"issue":"5","key":"2023092615572775800_fcad245-B143","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/cercor\/bhm155","article-title":"Que PASA? The posterior-anterior shift in aging","volume":"18","author":"Davis","year":"2008","journal-title":"Cereb Cortex"},{"issue":"1","key":"2023092615572775800_fcad245-B144","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1162\/0898929052880048","article-title":"Aging and the neural correlates of successful picture encoding: Frontal activations compensate for decreased medial-temporal activity","volume":"17","author":"Gutchess","year":"2005","journal-title":"J Cogn Neurosci"},{"key":"2023092615572775800_fcad245-B145","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neubiorev.2015.08.013","article-title":"Putting age-related task activation into large-scale brain networks: A meta-analysis of 114 fMRI studies on healthy aging","volume":"57","author":"Li","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"issue":"5","key":"2023092615572775800_fcad245-B146","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0896-6273(02)00612-8","article-title":"Under-recruitment and nonselective recruitment: Dissociable neural mechanisms associated with aging","volume":"33","author":"Logan","year":"2002","journal-title":"Neuron"},{"issue":"Pt 9","key":"2023092615572775800_fcad245-B147","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1093\/brain\/awh608","article-title":"Region-specific changes in prefrontal function with age: A review of PET and fMRI studies on working and episodic memory","volume":"128","author":"Rajah","year":"2005","journal-title":"Brain"},{"issue":"4","key":"2023092615572775800_fcad245-B148","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1162\/jocn.2009.21230","article-title":"Span, CRUNCH, and beyond: Working memory capacity and the aging brain","volume":"22","author":"Schneider-Garces","year":"2010","journal-title":"J Cogn Neurosci"},{"issue":"8","key":"2023092615572775800_fcad245-B149","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.neubiorev.2010.01.009","article-title":"Reliable differences in brain activity between young and old adults: A quantitative meta-analysis across multiple cognitive domains","volume":"34","author":"Spreng","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"key":"2023092615572775800_fcad245-B150","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.arr.2016.02.006","article-title":"Functional neuroimaging of normal aging: Declining brain, adapting brain","volume":"30","author":"Sugiura","year":"2016","journal-title":"Ageing Res Rev"},{"issue":"7","key":"2023092615572775800_fcad245-B151","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrn3256","article-title":"The cognitive neuroscience of ageing","volume":"13","author":"Grady","year":"2012","journal-title":"Nat Rev Neurosci"},{"issue":"46","key":"2023092615572775800_fcad245-B152","doi-asserted-by":"crossref","first-page":"E4997-","DOI":"10.1073\/pnas.1415122111","article-title":"Decreased segregation of brain systems across the healthy adult lifespan","volume":"111","author":"Chan","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"28","key":"2023092615572775800_fcad245-B153","doi-asserted-by":"crossref","first-page":"5534","DOI":"10.1523\/JNEUROSCI.1451-18.2019","article-title":"Longitudinal changes in the cerebral Cortex functional organization of healthy elderly","volume":"39","author":"Chong","year":"2019","journal-title":"J Neurosci"},{"issue":"7","key":"2023092615572775800_fcad245-B154","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/cercor\/bhu012","article-title":"A brain-wide study of age-related changes in functional connectivity","volume":"25","author":"Geerligs","year":"2015","journal-title":"Cereb Cortex"},{"key":"2023092615572775800_fcad245-B155","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neurobiolaging.2016.02.020","article-title":"Age differences in the functional interactions among the default, frontoparietal control, and dorsal attention networks","volume":"41","author":"Grady","year":"2016","journal-title":"Neurobiol Aging"},{"key":"2023092615572775800_fcad245-B156","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cortex.2014.12.001","article-title":"Resting-state anticorrelations between medial and lateral prefrontal cortex: Association with working memory, aging, and individual differences","volume":"64","author":"Keller","year":"2015","journal-title":"Cortex"},{"key":"2023092615572775800_fcad245-B157","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neurobiolaging.2016.05.020","article-title":"Attenuated anticorrelation between the default and dorsal attention networks with aging: Evidence from task and rest","volume":"45","author":"Spreng","year":"2016","journal-title":"Neurobiol Aging"},{"key":"2023092615572775800_fcad245-B158","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neuroimage.2018.02.066","article-title":"Evolution of spatial and temporal features of functional brain networks across the lifespan","volume":"173","author":"Vij","year":"2018","journal-title":"Neuroimage"},{"issue":"10","key":"2023092615572775800_fcad245-B159","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1093\/cercor\/bhab122","article-title":"Alzheimer's pathology is associated with dedifferentiation of intrinsic functional memory networks in aging","volume":"31","author":"Cassady","year":"2021","journal-title":"Cereb Cortex"},{"issue":"8","key":"2023092615572775800_fcad245-B160","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1093\/cercor\/bhm207","article-title":"Reduced resting-state brain activity in the \u201cdefault network\u201d in normal aging","volume":"18","author":"Damoiseaux","year":"2008","journal-title":"Cereb Cortex"},{"issue":"1","key":"2023092615572775800_fcad245-B161","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neulet.2011.08.059","article-title":"Aging-related changes in the default mode network and its anti-correlated networks: A resting-state fMRI study","volume":"504","author":"Wu","year":"2011","journal-title":"Neurosci Lett"},{"issue":"1","key":"2023092615572775800_fcad245-B162","first-page":"386","article-title":"Individual variability of the system-level organization of the human brain","volume":"27","author":"Gordon","year":"2017","journal-title":"Cereb Cortex"},{"issue":"3","key":"2023092615572775800_fcad245-B163","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.neuron.2015.06.037","article-title":"Functional system and areal organization of a highly sampled individual human brain","volume":"87","author":"Laumann","year":"2015","journal-title":"Neuron"},{"issue":"3","key":"2023092615572775800_fcad245-B164","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.neuron.2012.12.028","article-title":"Individual variability in functional connectivity architecture of the human brain","volume":"77","author":"Mueller","year":"2013","journal-title":"Neuron"},{"key":"2023092615572775800_fcad245-B165","doi-asserted-by":"crossref","first-page":"119511","DOI":"10.1016\/j.neuroimage.2022.119511","article-title":"Covariance-based vs. correlation-based functional connectivity dissociates healthy aging from Alzheimer disease","volume":"261","author":"Strain","year":"2022","journal-title":"Neuroimage"},{"issue":"3","key":"2023092615572775800_fcad245-B166","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.neuroimage.2012.08.004","article-title":"Network-specific effects of age and in-scanner subject motion: A resting-state fMRI study of 238 healthy adults","volume":"63","author":"Mowinckel","year":"2012","journal-title":"Neuroimage"},{"issue":"3","key":"2023092615572775800_fcad245-B167","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion","volume":"59","author":"Power","year":"2012","journal-title":"Neuroimage"},{"issue":"1","key":"2023092615572775800_fcad245-B168","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.neuroimage.2011.07.044","article-title":"The influence of head motion on intrinsic functional connectivity MRI","volume":"59","author":"Van Dijk","year":"2012","journal-title":"Neuroimage"},{"key":"2023092615572775800_fcad245-B169","doi-asserted-by":"crossref","first-page":"e5176","DOI":"10.7717\/peerj.5176","article-title":"Age differences in head motion and estimates of cortical morphology","volume":"6","author":"Madan","year":"2018","journal-title":"PeerJ"},{"issue":"4","key":"2023092615572775800_fcad245-B170","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.neuroimage.2011.06.085","article-title":"Heterogeneity of functional activation during memory encoding across hippocampal subfields in temporal lobe epilepsy","volume":"58","author":"Das","year":"2011","journal-title":"Neuroimage"},{"issue":"5870","key":"2023092615572775800_fcad245-B171","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1126\/science.1152882","article-title":"Pattern separation in the human hippocampal CA3 and dentate gyrus","volume":"319","author":"Bakker","year":"2008","journal-title":"Science"},{"issue":"12","key":"2023092615572775800_fcad245-B172","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1523\/JNEUROSCI.3225-16.2017","article-title":"Ultra-High-Field fMRI reveals a role for the subiculum in scene perceptual discrimination","volume":"37","author":"Hodgetts","year":"2017","journal-title":"J Neurosci"},{"issue":"21","key":"2023092615572775800_fcad245-B173","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1073\/pnas.1101567108","article-title":"Age-related memory deficits linked to circuit-specific disruptions in the hippocampus","volume":"108","author":"Yassa","year":"2011","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcad245\/51553530\/fcad245.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/5\/5\/fcad245\/51762020\/fcad245.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/5\/5\/fcad245\/51762020\/fcad245.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:22:29Z","timestamp":1730074949000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcad245\/7273777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":173,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,8,31]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcad245","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023]]},"published":{"date-parts":[[2023]]},"article-number":"fcad245"}}