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Moreover, the disruption of cerebral blood flow (perfusion) can be observed in areas surrounding and distal to the lesion. These structurally preserved but suboptimally perfused regions may also affect recovery. Thus, to better understand aphasia recovery, the relationship between cerebral perfusion and language needs to be systematically examined. In the current study, we aimed to evaluate (i) how stroke affects perfusion outside of lesioned areas in chronic aphasia and (ii) how perfusion in specific cortical areas and perilesional tissue relates to language outcomes in aphasia. We analysed perfusion data from a large sample of participants with chronic aphasia due to left hemisphere stroke (n = 43) and age-matched healthy controls (n = 25). We used anatomically defined regions of interest that covered the frontal, parietal, and temporal areas of the perisylvian cortex in both hemispheres, areas typically known to support language, along with several control regions not implicated in language processing. For the aphasia group, we also looked at three regions of interest in the perilesional tissue. We compared perfusion levels between the two groups and investigated the relationship between perfusion levels and language subtest scores while controlling for demographic and lesion variables. First, we observed that perfusion levels outside the lesioned areas were significantly reduced in frontal and parietal regions in the left hemisphere in people with aphasia compared to the control group, while no differences were observed for the right hemisphere regions. Second, we found that perfusion in the left temporal lobe (and most strongly in the posterior part of both superior and middle temporal gyri) and inferior parietal areas (supramarginal gyrus) was significantly related to residual expressive and receptive language abilities. In contrast, perfusion in the frontal regions did not show such a relationship; no relationship with language was also observed for perfusion levels in control areas and all right hemisphere regions. Third, perilesional perfusion was only marginally related to language production abilities. Cumulatively, the current findings demonstrate that blood flow is reduced beyond the lesion site in chronic aphasia and that hypoperfused neural tissue in critical temporoparietal language areas has a negative impact on behavioural outcomes. These results, using perfusion imaging, underscore the critical and general role that left hemisphere posterior temporal regions play in various expressive and receptive language abilities. Overall, the study highlights the importance of exploring perfusion measures in stroke.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad252","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:35:38Z","timestamp":1696484138000},"source":"Crossref","is-referenced-by-count":7,"title":["Cerebral perfusion in post-stroke aphasia and its relationship to residual language abilities"],"prefix":"10.1093","volume":"6","author":[{"given":"Maria V","family":"Ivanova","sequence":"first","affiliation":[{"name":"Department of Psychology, University of California , Berkeley, CA 94720 , USA"},{"name":"Research Service, VA Northern California Health Care System , Martinez, CA 94553 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Pappas","sequence":"additional","affiliation":[{"name":"Stevens Neuroimaging and Informatics Institute, University of Southern California , Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Inglis","sequence":"additional","affiliation":[{"name":"Henry H. Wheeler, Jr. Brain Imaging Center, University of California , Berkeley, CA 94720 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis L","family":"Pracar","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California , Berkeley, CA 94720 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4297-014X","authenticated-orcid":false,"given":"Timothy J","family":"Herron","sequence":"additional","affiliation":[{"name":"Research Service, VA Northern California Health Care System , Martinez, CA 94553 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana V","family":"Baldo","sequence":"additional","affiliation":[{"name":"Research Service, VA Northern California Health Care System , Martinez, CA 94553 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S","family":"Kayser","sequence":"additional","affiliation":[{"name":"Division of Neurology, San Francisco VA Health Care System , San Francisco, CA 94121 , USA"},{"name":"Department of Neurology, University of California San Francisco , San Francisco, CA 94158 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"D\u2019Esposito","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California , Berkeley, CA 94720 , USA"},{"name":"Neurology Service, VA Northern California Health Care System , Martinez, CA 94553 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina F","family":"Dronkers","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California , Berkeley, CA 94720 , USA"},{"name":"Depertment of Neurology, University of California , Davis, CA 95817 , 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