{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:18:37Z","timestamp":1785352717225,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":285,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Essential tremor and Parkinson\u2019s disease patients may present with various tremor types. Overlapping tremor features can be challenging to diagnosis and misdiagnosis is common. Although underlying neurodegenerative mechanisms are suggested, neuroimaging studies arrived at controversial results and often the different tremor types were not considered. We investigated whether different tremor types displayed distinct structural brain features. Structural MRI of 61 patients with essential tremor and 29 with tremor-dominant Parkinson\u2019s disease was analysed using a fully automated artificial-intelligence-based brain volumetry to compare volumes of several cortical and subcortical regions. Furthermore, essential tremor subgroups with and without rest tremor or more pronounced postural and kinetic tremor were investigated. Deviations from an internal reference collective of age- and sex-adjusted healthy controls and volumetric differences between groups were examined; regression analysis was used to determine the contribution of disease-related factors on volumetric measurements. Compared with healthy controls, essential tremor and tremor-dominant Parkinson\u2019s disease patients displayed deviations in the occipital lobes, hippocampus, putamen, pallidum and mesencephalon while essential tremor patients exhibited decreased volumes within the nucleus caudatus and thalamus. Analysis of covariance revealed similar volumetric patterns in both diseases. Essential tremor patients without rest tremor showed a significant atrophy within the thalamus compared to tremor-dominant Parkinson\u2019s disease and atrophy of the mesencephalon and putamen were found in both subgroups compared to essential tremor with rest tremor. Disease-related factors contribute to volumes of occipital lobes in both diseases and to volumes of temporal lobes in essential tremor and the putamen in Parkinson\u2019s disease. Fully automated artificial-intelligence-based volumetry provides a fast and rater-independent method to investigate brain volumes in different neurological disorders and allows comparisons with an internal reference collective. Our results indicate that essential tremor and tremor-dominant Parkinson\u2019s disease share structural changes, indicative of neurodegenerative mechanisms, particularly of the basal-ganglia-thalamocortical circuitry. A discriminating, possibly disease-specific involvement of the thalamus was found in essential tremor patients without rest tremor and the mesencephalon and putamen in tremor-dominant Parkinson\u2019s disease and essential tremor without rest tremor.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad271","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T22:10:32Z","timestamp":1697235032000},"source":"Crossref","is-referenced-by-count":17,"title":["Artificial-intelligence-based MRI brain volumetry in patients with essential tremor and tremor-dominant Parkinson\u2019s disease"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8972-5483","authenticated-orcid":false,"given":"Veronika","family":"Purrer","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital Bonn , 53127 Bonn , Germany"},{"name":"German Center of Neurodegenerative Diseases (DZNE) , 53127 Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Pohl","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Bonn , 53127 Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia M","family":"Lueckel","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Bonn , 53127 Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeri","family":"Borger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Bonn , 53127 Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Bonn , 53127 Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Radbruch","sequence":"additional","affiliation":[{"name":"German Center of Neurodegenerative Diseases (DZNE) , 53127 Bonn , Germany"},{"name":"Department of Neuroradiology, University Hospital Bonn , 53127 Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ullrich","family":"W\u00fcllner","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Bonn , 53127 Bonn , Germany"},{"name":"German Center of Neurodegenerative Diseases (DZNE) , 53127 Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic Carsten","family":"Schmeel","sequence":"additional","affiliation":[{"name":"German Center of Neurodegenerative Diseases (DZNE) , 53127 Bonn , Germany"},{"name":"Department of Neuroradiology, University Hospital Bonn , 53127 Bonn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"issue":"6","key":"2023122115010890100_fcad271-B1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1212\/WNL.0000000000002350","article-title":"Accuracy of clinical diagnosis of Parkinson disease: A systematic review and meta-analysis","volume":"86","author":"Rizzo","year":"2016","journal-title":"Neurology"},{"issue":"12","key":"2023122115010890100_fcad271-B2","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s004150070053","article-title":"Essential tremor: An overdiagnosed condition?","volume":"247","author":"Schrag","year":"2000","journal-title":"J Neurol"},{"key":"2023122115010890100_fcad271-B3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.5334\/tohm.441","article-title":"Essential tremor and Parkinson's disease: Exploring the 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