{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:45:06Z","timestamp":1781534706130,"version":"3.54.5"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":339,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UK Medical Research Council Career Development Fellowship","award":["MR\/K006673\/1"],"award-info":[{"award-number":["MR\/K006673\/1"]}]},{"name":"Wellcome Collaborative Award","award":["215573\/Z\/19\/Z"],"award-info":[{"award-number":["215573\/Z\/19\/Z"]}]},{"name":"Wellcome Principal Research Fellowship"},{"name":"National Institute for Health and Care Research Oxford Biomedical Research Centre"},{"name":"National Institute for Health and Care Research Oxford Health Clinical Research Facility"},{"name":"National Institute for Health and Care Research Clinical Lectureship"},{"DOI":"10.13039\/501100000266","name":"UK Engineering and Physical Sciences Research Council","doi-asserted-by":"crossref","award":["EP\/L016052\/1"],"award-info":[{"award-number":["EP\/L016052\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Oxford Christopher Welch Scholarship in Biological Sciences","award":["GAF1415_CB2_ MSD_758342"],"award-info":[{"award-number":["GAF1415_CB2_ MSD_758342"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Huntington\u2019s and Parkinson\u2019s disease are two movement disorders representing mainly opposite states of the basal ganglia inhibitory function. Despite being an integral part of the cortico-subcortico-cortical circuitry, the subthalamic nucleus function has been studied at the level of detail required to isolate its signal only through invasive studies in Huntington\u2019s and Parkinson\u2019s disease. Here, we tested whether the subthalamic nucleus exhibited opposite functional signatures in early Huntington\u2019s and Parkinson\u2019s disease. We included both movement disorders in the same whole-brain imaging study, and leveraged ultra-high-field 7T MRI to achieve the very fine resolution needed to investigate the smallest of the basal ganglia nuclei. Eleven of the 12 Huntington\u2019s disease carriers were recruited at a premanifest stage, while 16 of the 18 Parkinson\u2019s disease patients only exhibited unilateral motor symptoms (15 were at Stage I of Hoehn and Yahr off medication). Our group comparison interaction analyses, including 24 healthy controls, revealed a differential effect of Huntington\u2019s and Parkinson\u2019s disease on the functional connectivity at rest of the subthalamic nucleus within the sensorimotor network, i.e. an opposite effect compared with their respective age-matched healthy control groups. This differential impact in the subthalamic nucleus included an area precisely corresponding to the deep brain stimulation \u2018sweet spot\u2019\u2014the area with maximum overall efficacy\u2014in Parkinson\u2019s disease. Importantly, the severity of deviation away from controls\u2019 resting-state values in the subthalamic nucleus was associated with the severity of motor and cognitive symptoms in both diseases, despite functional connectivity going in opposite directions in each disorder. We also observed an altered, opposite impact of Huntington\u2019s and Parkinson\u2019s disease on functional connectivity within the sensorimotor cortex, once again with relevant associations with clinical symptoms. The high resolution offered by the 7T scanner has thus made it possible to explore the complex interplay between the disease effects and their contribution on the subthalamic nucleus, and sensorimotor cortex. Taken altogether, these findings reveal for the first time non-invasively in humans a differential, clinically meaningful impact of the pathophysiological process of these two movement disorders on the overall sensorimotor functional connection of the subthalamic nucleus and sensorimotor cortex.<\/jats:p>","DOI":"10.1093\/braincomms\/fcad282","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T05:36:19Z","timestamp":1701927379000},"source":"Crossref","is-referenced-by-count":9,"title":["Subthalamic nucleus shows opposite functional connectivity pattern in Huntington\u2019s and Parkinson\u2019s disease"],"prefix":"10.1093","volume":"5","author":[{"given":"Stefania","family":"Evangelisti","sequence":"first","affiliation":[{"name":"FMRIB Centre, Wellcome Centre for Integrative Neuroimaging, John Radcliffe Hospital, University of Oxford , OX3 9DU Oxford , UK"},{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford , OX3 9DU Oxford , UK"},{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna , 40127 Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirius","family":"Boessenkool","sequence":"additional","affiliation":[{"name":"FMRIB Centre, Wellcome Centre for Integrative Neuroimaging, John Radcliffe Hospital, University of Oxford , OX3 9DU Oxford , UK"},{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford , OX3 9DU Oxford , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris Patrick","family":"Pflanz","sequence":"additional","affiliation":[{"name":"FMRIB Centre, Wellcome Centre for Integrative Neuroimaging, John Radcliffe Hospital, University of Oxford , OX3 9DU Oxford , UK"},{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford , OX3 9DU Oxford , UK"},{"name":"Stroke Research Group, Department of Clinical Neuroscience, University of Cambridge , CB2 0QQ Cambridge , 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