{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:53:54Z","timestamp":1792068834882,"version":"4.4.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurological disorders include a variety of conditions, including Alzheimer\u2019s disease, motor neuron disease and Parkinson\u2019s disease, affecting longevity and quality of life, and their pathogenesis is associated with oxidative stress. Several of the chronic neurodegenerative pathologies of the CNS share some common features, such as oxidative stress, inflammation, synapse dysfunctions, protein misfolding and defective autophagia. Neuroinflammation can involve the activation of mast cells, contributing to oxidative stress, in addition to other sources of reactive oxygen species. Antioxidants can powerfully neutralize reactive oxygen species and free radicals, decreasing oxidative damage. Antioxidant genes, like the manganese superoxide dismutase enzyme, can undergo epigenetic changes that reduce their expression, thus increasing oxidative stress in tissue. Alternatively, DNA can be altered by free radical damage. The epigenetic landscape of these genes can change antioxidant function and may result in neurodegenerative disease. This imbalance of free radical production and antioxidant function increases the reactive oxygen species that cause cell damage in neurons and is often observed as an age-related event. Increased antioxidant expression in mice is protective against reactive oxygen species in neurons as is the exogenous supplementation of antioxidants. Manganese superoxide dismutase requires manganese for its enzymic function. Antioxidant therapy is considered for age-related neurodegenerative diseases, and a new mimetic of a manganese superoxide dismutase, avasopasem manganese, is described and suggested as a putative treatment to reduce the oxidative stress that causes neurodegenerative disease. The aim of this narrative review is to explore the evidence that oxidative stress causes neurodegenerative damage and the role of antioxidant genes in inhibiting reactive oxygen species damage. Can the neuronal environment of oxidative stress, causing neuroinflammation and neurodegeneration, be reduced or reversed?<\/jats:p>","DOI":"10.1093\/braincomms\/fcad356","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T18:28:07Z","timestamp":1703960887000},"source":"Crossref","is-referenced-by-count":412,"title":["Role of oxidative stress in neurodegenerative disorders: a review of reactive oxygen species and prevention by antioxidants"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2660-6744","authenticated-orcid":false,"given":"Annwyne","family":"Houldsworth","sequence":"first","affiliation":[{"name":"University of Exeter Medical School , Exeter, Devon EX2 4TH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"issue":"3","key":"2024022920041647700_fcad356-B1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1474-4422(19)30411-9","article-title":"The global burden of neurological disorders: Translating evidence into policy","volume":"19","author":"Feigin","year":"2020","journal-title":"Lancet Neurol"},{"issue":"198","key":"2024022920041647700_fcad356-B2","doi-asserted-by":"crossref","first-page":"20220406","DOI":"10.1098\/rsif.2022.0406","article-title":"Neurodegenerative disease of the brain: A survey of interdisciplinary approaches","volume":"20","author":"Davenport","year":"2023","journal-title":"J R Soc Interface"},{"issue":"3","key":"2024022920041647700_fcad356-B3","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3390\/ijms23031851","article-title":"A review of the common neurodegenerative disorders: Current therapeutic approaches and the potential role of nanotherapeutics","volume":"23","author":"Lamptey","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2024022920041647700_fcad356-B4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/01616412.2016.1251711","article-title":"Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders","volume":"39","author":"Islam","year":"2017","journal-title":"Neurol Res"},{"key":"2024022920041647700_fcad356-B5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cbi.2014.10.016","article-title":"Free radicals, reactive oxygen species, oxidative stress and its classification","volume":"224","author":"Lushchak","year":"2014","journal-title":"Chem Biol Interact"},{"issue":"1","key":"2024022920041647700_fcad356-B6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12291-014-0446-0","article-title":"Free radicals: Properties, sources, targets, and their implication in various diseases","volume":"30","author":"Phaniendra","year":"2015","journal-title":"Indian J Clin Biochem"},{"issue":"6","key":"2024022920041647700_fcad356-B7","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/01926230290166724","article-title":"Oxidation of biological systems: Oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification","volume":"30","author":"Kohen","year":"2002","journal-title":"Toxicol Pathol"},{"issue":"14","key":"2024022920041647700_fcad356-B8","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1089\/ars.2015.6317","article-title":"Clinical relevance of biomarkers of oxidative stress","volume":"23","author":"Frijhoff","year":"2015","journal-title":"Antioxid Redox Signal"},{"issue":"9","key":"2024022920041647700_fcad356-B9","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1021\/acsabm.2c00411","article-title":"Role of reactive oxygen species in aging and age-related diseases: A review","volume":"5","author":"Anik","year":"2022","journal-title":"ACS Appl Bio Mater"},{"key":"2024022920041647700_fcad356-B10","doi-asserted-by":"crossref","first-page":"104795","DOI":"10.1016\/j.nbd.2020.104795","article-title":"Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer\u2019s disease","volume":"138","author":"Butterfield","year":"2020","journal-title":"Neurobiol Dis"},{"key":"2024022920041647700_fcad356-B11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13578-020-00386-3","article-title":"Insights into superoxide dismutase 3 in regulating biological and functional properties of mesenchymal stem cells","volume":"10","author":"Sah","year":"2020","journal-title":"Cell Biosci"},{"issue":"Pt 2","key":"2024022920041647700_fcad356-B12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J Physiol"},{"issue":"5","key":"2024022920041647700_fcad356-B13","first-page":"376","article-title":"Oxidative stress in neurodegenerative diseases","volume":"7","author":"Chen","year":"2012","journal-title":"Neural Regen Res"},{"issue":"7","key":"2024022920041647700_fcad356-B14","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid Redox Signal"},{"issue":"4","key":"2024022920041647700_fcad356-B15","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.mcn.2006.08.005","article-title":"Reactive oxygen species modulate the differentiation of neurons in clonal cortical cultures","volume":"33","author":"Tsatmali","year":"2006","journal-title":"Mol Cell Neurosci"},{"issue":"6","key":"2024022920041647700_fcad356-B16","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.2741\/4848","article-title":"Instrumental role for reactive oxygen species in the inflammatory response","volume":"25","author":"Fokam","year":"2020","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"1","key":"2024022920041647700_fcad356-B17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1159\/000492886","article-title":"Oxidative stress is the principal contributor to inflammasome activation in retinal pigment epithelium cells with defunct proteasomes and autophagy","volume":"49","author":"Piippo","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"10","key":"2024022920041647700_fcad356-B18","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The role of iron in brain ageing and neurodegenerative disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurol"},{"issue":"8","key":"2024022920041647700_fcad356-B19","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.2741\/4869","article-title":"Role of reactive oxygen species and iron in host defense against infection","volume":"25","author":"Dickson","year":"2020","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2024022920041647700_fcad356-B20","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.95616","volume-title":"Antioxidants\u2014Benefits, sources, mechanisms of action","author":"Ali Al-Mamary","year":"2021"},{"issue":"14","key":"2024022920041647700_fcad356-B21","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1089\/ars.2012.4581","article-title":"Dietary (poly)phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases","volume":"18","author":"Del Rio","year":"2013","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"2024022920041647700_fcad356-B22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0009-3084(96)02523-6","article-title":"Antioxidant activity of natural flavonoids is governed by number and location of their aromatic hydroxyl groups","volume":"79","author":"Chen","year":"1996","journal-title":"Chem Phys Lipids"},{"issue":"6","key":"2024022920041647700_fcad356-B23","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1111\/bph.14888","article-title":"Dietary antioxidants remodel DNA methylation patterns in chronic disease","volume":"177","author":"Beetch","year":"2020","journal-title":"Br J Pharmacol"},{"issue":"4","key":"2024022920041647700_fcad356-B24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/10408690490468489","article-title":"Antioxidants and prevention of chronic disease","volume":"44","author":"Willcox","year":"2004","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"8","key":"2024022920041647700_fcad356-B25","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.3390\/molecules24081583","article-title":"Oxidative stress: A key modulator in neurodegenerative diseases","volume":"24","author":"Singh","year":"2019","journal-title":"Molecules"},{"issue":"3","key":"2024022920041647700_fcad356-B26","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0891-5849(02)00905-X","article-title":"Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression","volume":"33","author":"Zelko","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"2024022920041647700_fcad356-B27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jprot.2013.08.001","article-title":"The human proteome organization chromosome 6 consortium: Integrating chromosome-centric and biology\/disease driven strategies","volume":"100","author":"Borchers","year":"2014","journal-title":"J Proteomics"},{"issue":"2","key":"2024022920041647700_fcad356-B28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/antiox7020025","article-title":"A review of the catalytic mechanism of human manganese superoxide dismutase","volume":"7","author":"Azadmanesh","year":"2018","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"2024022920041647700_fcad356-B29","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1038\/s41467-021-22290-1","article-title":"Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase","volume":"12","author":"Azadmanesh","year":"2021","journal-title":"Nat Commun"},{"issue":"3","key":"2024022920041647700_fcad356-B30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3390\/nu9030231","article-title":"Association of serum manganese levels with Alzheimer\u2019s disease and mild cognitive impairment: A systematic review and meta-analysis","volume":"9","author":"Du","year":"2017","journal-title":"Nutrients"},{"key":"2024022920041647700_fcad356-B31","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2741\/4665","article-title":"Manganese metabolism in humans","volume":"23","author":"Chen","year":"2018","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2024022920041647700_fcad356-B32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.freeradbiomed.2013.05.027","article-title":"SOD2 in mitochondrial dysfunction and neurodegeneration","volume":"62","author":"Flynn","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"2024022920041647700_fcad356-B33","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuroscience.2012.03.026","article-title":"Neurodegeneration and early lethality in superoxide dismutase 2-deficient mice: A comprehensive analysis of the central and peripheral nervous systems","volume":"212","author":"Oh","year":"2012","journal-title":"Neuroscience"},{"issue":"32","key":"2024022920041647700_fcad356-B34","doi-asserted-by":"crossref","first-page":"13576","DOI":"10.1073\/pnas.0902714106","article-title":"Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer\u2019s disease","volume":"106","author":"Massaad","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"2024022920041647700_fcad356-B35","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/molehr\/gal080","article-title":"Age-dependent changes in the expression of superoxide dismutases and catalase are associated with ultrastructural modifications in human granulosa cells","volume":"12","author":"Tatone","year":"2006","journal-title":"Mol Hum Reprod"},{"key":"2024022920041647700_fcad356-B36","doi-asserted-by":"crossref","first-page":"746329","DOI":"10.1155\/2015\/746329","article-title":"Association of the C47T polymorphism in SOD2 with amnestic mild cognitive impairment and Alzheimer\u2019s disease in carriers of the APOE\u03b54 allele","volume":"2015","author":"Gamarra","year":"2015","journal-title":"Dis Markers"},{"issue":"10","key":"2024022920041647700_fcad356-B37","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.3390\/cimb44100302","article-title":"Analysis of SOD2 rs4880 genetic variant in patients with Alzheimer\u2019s disease","volume":"44","author":"Siokas","year":"2022","journal-title":"Curr Issues Mol Biol"},{"issue":"1","key":"2024022920041647700_fcad356-B38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/07487304211064218","article-title":"Disturbance of the circadian system in shift work and its health impact","volume":"37","author":"Boivin","year":"2022","journal-title":"J Biol Rhythms"},{"key":"2024022920041647700_fcad356-B39","first-page":"29","article-title":"[Sleep, memory and learning]","volume":"79 Suppl 3","author":"Acosta","year":"2019","journal-title":"Medicina (B Aires)"},{"key":"2024022920041647700_fcad356-B40","doi-asserted-by":"crossref","first-page":"105210","DOI":"10.1016\/j.phrs.2020.105210","article-title":"Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis","volume":"161","author":"Morvaridzadeh","year":"2020","journal-title":"Pharmacol Res"},{"key":"2024022920041647700_fcad356-B41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.envres.2017.05.011","article-title":"Cadmium and Alzheimer\u2019s disease mortality in U.S. adults: Updated evidence with a urinary biomarker and extended follow-up time","volume":"157","author":"Peng","year":"2017","journal-title":"Environ Res"},{"issue":"4","key":"2024022920041647700_fcad356-B42","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/09603123.2013.835032","article-title":"Cellular mechanisms of cadmium-induced toxicity: A review","volume":"24","author":"Rani","year":"2014","journal-title":"Int J Environ Health Res"},{"issue":"7","key":"2024022920041647700_fcad356-B43","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.3390\/molecules26071844","article-title":"Superoxide dismutase administration: A review of proposed human uses","volume":"26","author":"Rosa","year":"2021","journal-title":"Molecules"},{"issue":"6","key":"2024022920041647700_fcad356-B44","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0301-0546(01)79069-6","article-title":"Anaphylactic shock caused by impurities in orgotein preparations","volume":"29","author":"de Benito","year":"2001","journal-title":"Allergol Immunopathol (Madr)"},{"key":"2024022920041647700_fcad356-B45","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2147\/DDDT.S267400","article-title":"Superoxide dismutase as an intervention for radiation therapy-associated toxicities: Review and profile of avasopasem manganese as a treatment option for radiation-induced mucositis","volume":"15","author":"Sonis","year":"2021","journal-title":"Drug Des Devel Ther"},{"key":"2024022920041647700_fcad356-B46","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-514-9_2","article-title":"Why is the nervous system vulnerable to oxidative Stress?","author":"Friedman","year":"2011","journal-title":"Oxidative Stress and Free Radical Damage in Neurology"},{"issue":"6","key":"2024022920041647700_fcad356-B47","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","article-title":"Brain energy metabolism: Focus on astrocyte-neuron metabolic cooperation","volume":"14","author":"B\u00e9langer","year":"2011","journal-title":"Cell Metab"},{"issue":"5","key":"2024022920041647700_fcad356-B48","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3390\/genes11050563","article-title":"Mitochondrial protein quality control mechanisms","volume":"11","author":"Jadiya","year":"2020","journal-title":"Genes (Basel)"},{"issue":"2","key":"2024022920041647700_fcad356-B49","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/21541248.2017.1356432","article-title":"Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2","volume":"10","author":"Patil","year":"2019","journal-title":"Small GTPases"},{"key":"2024022920041647700_fcad356-B50","doi-asserted-by":"crossref","first-page":"8590578","DOI":"10.1155\/2016\/8590578","article-title":"The role of reactive oxygen species in the pathogenesis of Alzheimer\u2019s disease, Parkinson\u2019s disease, and Huntington\u2019s disease: A mini review","volume":"2016","author":"Manoharan","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"2024022920041647700_fcad356-B51","doi-asserted-by":"crossref","first-page":"200","DOI":"10.12659\/MSMBR.893093","article-title":"Mast cells and neuroinflammation","volume":"20","author":"Dong","year":"2014","journal-title":"Med Sci Monit Basic Res"},{"issue":"8","key":"2024022920041647700_fcad356-B52","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.3390\/antiox11081421","article-title":"Oxidative stress in tauopathies: From cause to therapy","volume":"11","author":"Bartolome","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"8","key":"2024022920041647700_fcad356-B53","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.3390\/ijms20081959","article-title":"Crosstalk between oxidative stress and tauopathy","volume":"20","author":"Haque","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2024022920041647700_fcad356-B54","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neubiorev.2017.05.001","article-title":"Mast cells in neuroinflammation and brain disorders","volume":"79","author":"Hendriksen","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"issue":"11","key":"2024022920041647700_fcad356-B55","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.4103\/1673-5374.310608","article-title":"Neuroimmune connections between corticotropin-releasing hormone and mast cells: Novel strategies for the treatment of neurodegenerative diseases","volume":"16","author":"Bhuiyan","year":"2021","journal-title":"Neural Regen Res"},{"key":"2024022920041647700_fcad356-B56","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fnagi.2020.00265","article-title":"Mechanisms of pathogenic tau and A\u03b2 protein spreading in Alzheimer\u2019s disease","volume":"12","author":"d\u2019Errico","year":"2020","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"2024022920041647700_fcad356-B57","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3390\/ijms22031093","article-title":"Decoding mast cell-microglia communication in neurodegenerative diseases","volume":"22","author":"Sandhu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024022920041647700_fcad356-B58","doi-asserted-by":"crossref","first-page":"742065","DOI":"10.3389\/fnins.2021.742065","article-title":"Microglia in neuroinflammation and neurodegeneration: From understanding to therapy","volume":"15","author":"Muzio","year":"2021","journal-title":"Front Neurosci"},{"issue":"2","key":"2024022920041647700_fcad356-B59","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/oxfordjournals.jbchem.a002969","article-title":"Microglia: Activation and their significance in the central nervous system","volume":"130","author":"Nakajima","year":"2001","journal-title":"J Biochem"},{"issue":"3","key":"2024022920041647700_fcad356-B60","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: Where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"2024022920041647700_fcad356-B61","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.201709069","article-title":"Microglia in Alzheimer\u2019s disease","volume":"217","author":"Hansen","year":"2018","journal-title":"J Cell Biol"},{"issue":"4","key":"2024022920041647700_fcad356-B62","doi-asserted-by":"crossref","first-page":"662","DOI":"10.2174\/157015911798376244","article-title":"Neuronal and vascular oxidative stress in Alzheimer\u2019s disease","volume":"9","author":"Massaad","year":"2011","journal-title":"Curr Neuropharmacol"},{"issue":"8","key":"2024022920041647700_fcad356-B63","doi-asserted-by":"crossref","first-page":"e20210542","DOI":"10.1084\/jem.20210542","article-title":"Activated microglia mitigate A\u03b2-associated tau seeding and spreading","volume":"218","author":"Gratuze","year":"2021","journal-title":"J Exp Med"},{"key":"2024022920041647700_fcad356-B64","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.2147\/JIR.S350109","article-title":"Microglia-mediated neuroinflammation: A potential target for the treatment of cardiovascular diseases","volume":"15","author":"Wang","year":"2022","journal-title":"J Inflamm Res"},{"issue":"6","key":"2024022920041647700_fcad356-B65","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.3390\/ijms24065383","article-title":"New pathways identify novel drug targets for the prevention and treatment of Alzheimer\u2019s disease","volume":"24","author":"Penke","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"10","key":"2024022920041647700_fcad356-B66","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr Biol"},{"issue":"6","key":"2024022920041647700_fcad356-B67","doi-asserted-by":"crossref","first-page":"e38026","DOI":"10.1371\/journal.pone.0038026","article-title":"Human SOD2 modification by dopamine quinones affects enzymatic activity by promoting its aggregation: Possible implications for Parkinson\u2019s disease","volume":"7","author":"Belluzzi","year":"2012","journal-title":"PLoS One"},{"issue":"10 Suppl 4","key":"2024022920041647700_fcad356-B68","first-page":"S24","article-title":"The pathogenesis of cell death in Parkinson\u2019s disease","volume":"66","author":"Jenner","year":"2006","journal-title":"Neurology"},{"issue":"4","key":"2024022920041647700_fcad356-B69","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JPD-130230","article-title":"The role of oxidative stress in Parkinson\u2019s disease","volume":"3","author":"Dias","year":"2013","journal-title":"J Parkinsons Dis"},{"issue":"1 Pt 2","key":"2024022920041647700_fcad356-B70","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jfma.2020.06.023","article-title":"Association of SOD2 p.V16A polymorphism with Parkinson\u2019s disease: A meta-analysis in Han Chinese","volume":"120","author":"Wu","year":"2021","journal-title":"J Formos Med Assoc"},{"issue":"11","key":"2024022920041647700_fcad356-B71","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1001\/jamaneurol.2019.2044","article-title":"Lifetime risk and heritability of amyotrophic lateral sclerosis","volume":"76","author":"Ryan","year":"2019","journal-title":"JAMA Neurol"},{"issue":"470","key":"2024022920041647700_fcad356-B72","doi-asserted-by":"crossref","first-page":"eaah3924","DOI":"10.1126\/scitranslmed.aah3924","article-title":"A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis","volume":"10","author":"Maier","year":"2018","journal-title":"Sci Transl Med"},{"issue":"12","key":"2024022920041647700_fcad356-B73","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1056\/NEJMoa2204705","article-title":"Trial of antisense oligonucleotide tofersen for SOD1 ALS","volume":"387","author":"Miller","year":"2022","journal-title":"N Engl J Med"},{"key":"2024022920041647700_fcad356-B74","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fnagi.2014.00173","article-title":"The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosis","volume":"6","author":"Lovejoy","year":"2014","journal-title":"Front Aging Neurosci"},{"issue":"6 Pt A","key":"2024022920041647700_fcad356-B75","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/j.bbadis.2018.03.019","article-title":"Age-related NMDA signaling alterations in SOD2 deficient mice","volume":"1864","author":"Carvajal","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2024022920041647700_fcad356-B76","article-title":"Advances in antioxidant nanomedicines for imaging and therapy of Alzheimer\u2019s disease","author":"Hasan","year":"2022","journal-title":"Antioxid Redox Signal"},{"key":"2024022920041647700_fcad356-B77","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fnmol.2020.00041","article-title":"Oxidative stress in cognitive and epigenetic aging: A retrospective glance","volume":"13","author":"Kandlur","year":"2020","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"2024022920041647700_fcad356-B78","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"2024022920041647700_fcad356-B79","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1167\/iovs.12-10854","article-title":"Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: Role of histone methylation","volume":"54","author":"Zhong","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2024022920041647700_fcad356-B80","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3389\/fncel.2020.00209","article-title":"Glia crosstalk in neuroinflammatory diseases","volume":"14","author":"Bernaus","year":"2020","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"2024022920041647700_fcad356-B81","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1756-8722-6-19","article-title":"Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers","volume":"6","author":"Li","year":"2013","journal-title":"J Hematol Oncol"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcad356\/54933849\/fcad356.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/6\/1\/fcad356\/56688635\/fcad356.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/6\/1\/fcad356\/56688635\/fcad356.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T15:05:10Z","timestamp":1709219110000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcad356\/7504872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,28]]},"references-count":81,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,12,28]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcad356","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2023,12,28]]},"article-number":"fcad356"}}