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Essential tremor, as characterized by tremor during action, is proposed to be driven by a dysfunction in the cerebello-thalamo-cerebral circuit that is evident not only during motor actions but also during rest. Stimulation effects on resting-state functional connectivity were investigated by functional MRI in 16 essential tremor patients with fully implanted deep brain stimulation in the caudal zona incerta during On-and-Off therapeutic stimulation, in a counterbalanced design. Functional connectivity was calculated between different constellations of sensorimotor as well as non-sensorimotor regions (as derived from seed-based and data-driven approaches), and compared between On and Off stimulation. We found that deep brain stimulation did not modulate resting-state functional connectivity. The lack of modulation by deep brain stimulation during resting-state, in combination with previously demonstrated effects on the cerebello-thalamo-cerebral circuit during motor tasks, suggests an action-dependent modulation of the stimulation in essential tremor.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae012","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T09:50:34Z","timestamp":1706349034000},"source":"Crossref","is-referenced-by-count":3,"title":["Deep brain stimulation does not modulate resting-state functional connectivity in essential tremor"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3068-0065","authenticated-orcid":false,"given":"Amar","family":"Awad","sequence":"first","affiliation":[{"name":"Ume\u00e5 Center for Functional Brain Imaging (UFBI), Ume\u00e5 University , 90187 Ume\u00e5 , Sweden"},{"name":"Department of Integrative Medical Biology, Physiology Section, Ume\u00e5 University , 90187 Ume\u00e5 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Grill","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Center for Functional Brain Imaging (UFBI), Ume\u00e5 University , 90187 Ume\u00e5 , Sweden"},{"name":"Department of Radiation Sciences, Ume\u00e5 University , 90185 Ume\u00e5 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patric","family":"Blomstedt","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Neuroscience, Ume\u00e5 University , 90185 Ume\u00e5 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Nyberg","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Center for Functional Brain Imaging (UFBI), Ume\u00e5 University , 90187 Ume\u00e5 , Sweden"},{"name":"Department of Integrative Medical Biology, Physiology Section, Ume\u00e5 University , 90187 Ume\u00e5 , Sweden"},{"name":"Department of Radiation Sciences, Ume\u00e5 University , 90185 Ume\u00e5 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Center for Functional Brain Imaging (UFBI), Ume\u00e5 University , 90187 Ume\u00e5 , Sweden"},{"name":"Department of Integrative Medical Biology, Physiology Section, Ume\u00e5 University , 90187 Ume\u00e5 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"issue":"1","key":"2024043010131166500_fcae012-B1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/mds.27121","article-title":"Consensus statement on the classification of tremors. 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