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The purpose of this non-randomized longitudinal controlled trial was to assess, using intent-to-treat analysis, the effects of an 8-week home intervention of prosthetic use on the sensorimotor cortex in paediatrics with congenital upper-limb reduction deficiency. A paediatric population with congenital upper-limb reduction deficiency (n = 14) who were aged 6\u201318 years and who had a 20\u00b0 or greater range of motion in the appropriate joint of the affected arm to move the body-powered prosthesis were enrolled. An age- and sex-matched control group (n = 14) was also enrolled. Participants were non-randomized and fitted with a custom low-cost 3D printed prosthesis and participated in 8 weeks of prosthetic use training at home. Control participants utilized a prosthetic simulator. The home intervention incorporated daily use training and exercises utilizing the prosthesis in direct use and assistive tasks explained by the researchers. After the home intervention, both groups displayed significant improvements in gross manual dexterity. During prosthetic use with the affected limb, significant increases in oxygenated hemodynamic responses were only displayed in the left premotor cortex of the upper-limb reduction deficiency group. The novel findings of this non-randomized longitudinal controlled trial suggest that the intervention may have improved the functional role of the left hemisphere which translated to the improvement of learning direction during adaptation to visuomotor control. The prosthetic home intervention was assumed to provide closed-loop training which could provide a direct benefit to the motor development of paediatrics with upper-limb reduction deficiency.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae044","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T08:48:31Z","timestamp":1720428511000},"source":"Crossref","is-referenced-by-count":4,"title":["Prosthetic home intervention induces cortical plasticity in paediatrics with congenital limb reduction"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7402-2654","authenticated-orcid":false,"given":"Jordan A","family":"Borrell","sequence":"first","affiliation":[{"name":"Department of Biomechanics, University of Nebraska at Omaha , Omaha, NE 68182 , USA"},{"name":"Center for Biomedical Rehabilitation and Manufacturing, University of Nebraska at Omaha , Omaha, NE 68182 , USA"},{"name":"Department of Occupational Therapy Education, 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