{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:32:42Z","timestamp":1787729562388,"version":"build-2784847793"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":50,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-18-CE45-0013"],"award-info":[{"award-number":["ANR-18-CE45-0013"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"d'EXcellence Bordeaux","award":["ANR-10-IDEX-03-02"],"award-info":[{"award-number":["ANR-10-IDEX-03-02"]}]},{"DOI":"10.13039\/501100004562","name":"French Ministry of Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Rechercghe Scientifique","doi-asserted-by":"publisher","award":["PID2020-118608RB-I00"],"award-info":[{"award-number":["PID2020-118608RB-I00"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministerio de Ciencia e innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Brain charts for the human lifespan have been recently proposed to build dynamic models of brain anatomy in normal aging and various neurological conditions. They offer new possibilities to quantify neuroanatomical changes from preclinical stages to death, where longitudinal MRI data are not available. In this study, we used brain charts to model the progression of brain atrophy in progressive supranuclear palsy\u2014Richardson syndrome. We combined multiple datasets (n = 8170 quality controlled MRI of healthy subjects from 22 cohorts covering the entire lifespan, and n = 62 MRI of progressive supranuclear palsy\u2014Richardson syndrome patients from the Four Repeat Tauopathy Neuroimaging Initiative (4RTNI)) to extrapolate lifetime volumetric models of healthy and progressive supranuclear palsy\u2014Richardson syndrome brain structures. We then mapped in time and space the sequential divergence between healthy and progressive supranuclear palsy\u2014Richardson syndrome charts. We found six major consecutive stages of atrophy progression: (i) ventral diencephalon (including subthalamic nuclei, substantia nigra, and red nuclei), (ii) pallidum, (iii) brainstem, striatum and amygdala, (iv) thalamus, (v) frontal lobe, and (vi) occipital lobe. The three structures with the most severe atrophy over time were the thalamus, followed by the pallidum and the brainstem. These results match the neuropathological staging of tauopathy progression in progressive supranuclear palsy\u2014Richardson syndrome, where the pathology is supposed to start in the pallido-nigro-luysian system and spreads rostrally via the striatum and the amygdala to the cerebral cortex, and caudally to the brainstem. This study supports the use of brain charts for the human lifespan to study the progression of neurodegenerative diseases, especially in the absence of specific biomarkers as in PSP.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae055","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T16:55:11Z","timestamp":1708448111000},"source":"Crossref","is-referenced-by-count":14,"title":["Staging of progressive supranuclear palsy-Richardson syndrome using MRI brain charts for the human lifespan"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3713-227X","authenticated-orcid":false,"given":"Vincent","family":"Planche","sequence":"first","affiliation":[{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, Univ. Bordeaux, CNRS, UMR 5293 1 , F-33000 Bordeaux , France"},{"name":"Centre M\u00e9moire Ressources Recherches, Service de Neurologie des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, P\u00f4le de Neurosciences Cliniques, CHU de Bordeaux , F-33000 Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9190-4819","authenticated-orcid":false,"given":"Boris","family":"Mansencal","sequence":"additional","affiliation":[{"name":"CNRS, Univ. Bordeaux, Bordeaux INP, Laboratoire Bordelais de Recherche en Informatique (LABRI), UMR5800 , F-33400 Talence , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose V","family":"Manjon","sequence":"additional","affiliation":[{"name":"Instituto de Aplicaciones de las Tecnolog\u00edas de la Informaci\u00f3n y de las Comunicaciones Avanzadas (ITACA), Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s\/n , 46022, Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassilios G","family":"Meissner","sequence":"additional","affiliation":[{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, Univ. Bordeaux, CNRS, UMR 5293 1 , F-33000 Bordeaux , France"},{"name":"Service de Neurologie des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, R\u00e9seau NS-Park\/FCRIN, CHU Bordeaux , F-33000, Bordeaux , France"},{"name":"Department of Medicine, Christchurch, and New Zealand Brain Research Institute , Christchurch, 8011 , New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7151-6325","authenticated-orcid":false,"given":"Thomas","family":"Tourdias","sequence":"additional","affiliation":[{"name":"Inserm U1215\u2014Neurocentre Magendie , Bordeaux F-33000 , France"},{"name":"Service de Neuroimagerie diagnostique et th\u00e9rapeutique, CHU de Bordeaux , F-33000 Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Coup\u00e9","sequence":"additional","affiliation":[{"name":"CNRS, Univ. 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