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Here, we studied the role of subthalamic circuits in hippocampus-associated spatial memory and striatal-associated spatial reversal learning formation in patients with Parkinson\u2019s disease, who underwent a deep brain stimulation of the subthalamic nucleus. Deep brain stimulation patients (Parkinson\u2019s disease-subthalamic nucleus: n = 26) and healthy subjects (n = 15) were tested in a novel experimental spatial memory task based on the Morris water maze that assesses both hippocampal place memory as well as spatial reversal learning. All subjects were trained to navigate to a distinct spatial location hidden within the virtual environment during 16 learning trials in a subthalamic nucleus Stim-On condition. Patients were then randomized into two groups with either a deep brain stimulation On or Off condition. Four hours later, subjects were retested in a delayed recall and reversal learning condition. The reversal learning was realized with a new hidden location that should be memorized during six consecutive trials. The performance was measured by means of an index indicating the improvement during the reversal learning. In the delayed recall condition, neither patients, healthy subjects nor the deep brain stimulation On- versus Off groups showed a difference in place memory performance of the former trained location. In the reversal learning condition, healthy subjects (reversal index 2.0) and patients in the deep brain stimulation On condition (reversal index 1.6) showed a significant improvement. However, patients in the deep brain stimulation Off condition (reversal index 1.1) performed significantly worse and did not improve. There were no differences between all groups in a final visual guided navigation task with a visible target. These results suggest that deep brain stimulation of subthalamic nucleus restores spatial reversal learning in a virtual navigation task in patients with Parkinson\u2019s disease and gives insight into the neuromodulation effects on cognition of subthalamic circuits in Parkinson\u2019s disease.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae068","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T20:18:52Z","timestamp":1709065132000},"source":"Crossref","is-referenced-by-count":2,"title":["Deep brain stimulation of the subthalamic nucleus restores spatial reversal learning in patients with Parkinson\u2019s disease"],"prefix":"10.1093","volume":"6","author":[{"given":"Isabel","family":"Schneider","sequence":"first","affiliation":[{"name":"Memory Disorders and Plasticity Group, Department of Neurology, University Hospital Schleswig-Holstein , Kiel 24105 , 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