{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:10:38Z","timestamp":1789035038610,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":78,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Henan Young and middle-aged health academic leader Project","award":["CYQ20210026"],"award-info":[{"award-number":["CYQ20210026"]}]},{"name":"Henan Young and middle-aged health academic leader Project","award":["CYQ20220019"],"award-info":[{"award-number":["CYQ20220019"]}]},{"name":"Lo-Hsu Medical Foundation"},{"name":"LotungPoh-Ai Hospital","award":["11001"],"award-info":[{"award-number":["11001"]}]},{"name":"LotungPoh-Ai Hospital","award":["11010"],"award-info":[{"award-number":["11010"]}]},{"name":"LotungPoh-Ai Hospital","award":["11013"],"award-info":[{"award-number":["11013"]}]},{"name":"LotungPoh-Ai Hospital","award":["11103"],"award-info":[{"award-number":["11103"]}]},{"name":"LotungPoh-Ai Hospital","award":["11303"],"award-info":[{"award-number":["11303"]}]},{"name":"LotungPoh-Ai Hospital","award":["11304"],"award-info":[{"award-number":["11304"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study investigates the association between postoperative agitated delirium and the risk of dementia in patients who were cognitively intact before undergoing major inpatient surgery. The study included inpatients aged 20 years or older who underwent major surgery requiring general, epidural, or spinal anaesthesia and hospitalization for over one day in Taiwan between 2008 and 2018. Patients were categorized into two groups based on the presence or absence of postoperative agitated delirium. Propensity score matching was conducted to balance various covariates known to influence dementia risk. The final analysis included 10 932 patients (5466 in each group). Multivariate Cox regression analysis was performed to assess the risk of dementia, and incidence rates and incidence rate ratios were calculated. After Propensity score matching, the study cohort comprised 5467 patients without postoperative agitated delirium and 5467 patients with postoperative agitated delirium. In the multivariate Cox regression analysis, the adjusted hazard ratio for dementia were 1.26 (95% confidence intervals, 1.08\u20131.46; P = 0.003) in the postoperative agitated delirium group compared to the no postoperative agitated delirium group. The incidence rates of dementia was significantly higher in patients with postoperative agitated delirium (97.65 versus 70.85 per 10 000 person-years), with an incidence rate ratio of 1.21 (95% CI: 1.04\u20131.40). Our study demonstrates a substantial rise in dementia incidence linked to postoperative agitated delirium. These findings stress the need for effective prevention and management strategies. Addressing this issue emerges as a vital clinical approach to reduce subsequent dementia risk, with broad implications for enhancing overall perioperative patient outcomes.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae076","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T18:40:28Z","timestamp":1710873628000},"source":"Crossref","is-referenced-by-count":9,"title":["The impact of postoperative agitated delirium on dementia in surgical patients"],"prefix":"10.1093","volume":"6","author":[{"given":"Mingyang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University , Zhengzhou 450003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University , Taipei 24205 , Taiwan"},{"name":"Artificial Intelligence Development Center, Fu Jen Catholic University , Taipei 24205 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5637-558X","authenticated-orcid":false,"given":"Szu-Yuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University , Taipei 24205 , Taiwan"},{"name":"Artificial Intelligence Development Center, Fu Jen Catholic University , Taipei 24205 , Taiwan"},{"name":"Department of Food Nutrition and Health Biotechnology, College of Medical and Health Science, Asia University , Taichung 41354 , Taiwan"},{"name":"Big Data Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital , Yilan 265501 , Taiwan"},{"name":"Division of Radiation Oncology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital , Yilan 265501 , Taiwan"},{"name":"Department of Healthcare Administration, College of Medical and Health Science, Asia University , Taichung 41354 , Taiwan"},{"name":"Cancer Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital , Yilan 41354 , Taiwan"},{"name":"Centers for Regional Anesthesia and Pain Medicine, Taipei Municipal Wan Fang Hospital, Taipei Medical University , Taipei 110301 , Taiwan"},{"name":"Department of Management, College of Management, Fo Guang University , Yilan 265501 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-784X","authenticated-orcid":false,"given":"Jiaqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University , Zhengzhou 450003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"issue":"8","key":"2024043010181130600_fcae076-B1","first-page":"CD012317","article-title":"Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery","volume":"8","author":"Miller","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"Suppl 1","key":"2024043010181130600_fcae076-B2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/anae.15607","article-title":"Evidence-based strategies to reduce the incidence of postoperative delirium: A narrative review","volume":"77","author":"Swarbrick","year":"2022","journal-title":"Anaesthesia"},{"issue":"2","key":"2024043010181130600_fcae076-B3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/1715163517690745","article-title":"Dementia: What pharmacists need to know","volume":"150","author":"Duong","year":"2017","journal-title":"Can Pharm J (Ott)"},{"key":"2024043010181130600_fcae076-B4","first-page":"125","article-title":"Clinical features and multidisciplinary approaches to dementia care","volume":"4","author":"Grand","year":"2011","journal-title":"J Multidiscip Healthc"},{"issue":"6","key":"2024043010181130600_fcae076-B5","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/bja\/aex404","article-title":"Perioperative cognitive disorders. 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