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We recently performed RNA sequencing of post-mortem PCC tissue samples from 26 elderly Rush Religious Orders Study participants who came to autopsy with an ante-mortem diagnosis of no cognitive impairment but who collectively displayed a range of Braak I\u2013IV neurofibrillary tangle stages. Notably, cognitively unimpaired subjects displaying high Braak stages may represent cognitive resilience to AD pathology. Transcriptomic data revealed elevated synaptic and ATP-related gene expression in Braak Stages III\/IV compared with Stages I\/II, suggesting these pathways may be related to PCC resilience. We also mined expression profiles for small non-coding micro-RNAs (miRNAs), which regulate mRNA stability and may represent an underexplored potential mechanism of resilience through the fine-tuning of gene expression within complex cellular networks. Twelve miRNAs were identified as differentially expressed between Braak Stages I\/II and III\/IV. However, the extent to which the levels of all identified miRNAs were associated with subject demographics, neuropsychological test performance and\/or neuropathological diagnostic criteria within this cohort was not explored. Here, we report that a total of 667 miRNAs are significantly associated (rho &amp;gt; 0.38, P &amp;lt; 0.05) with subject variables. There were significant positive correlations between miRNA expression levels and age, perceptual orientation and perceptual speed. By contrast, higher miRNA levels correlated negatively with semantic and episodic memory. Higher expression of 15 miRNAs associated with lower Braak Stages I\u2013II and 47 miRNAs were associated with higher Braak Stages III\u2013IV, suggesting additional mechanistic influences of PCC miRNA expression with resilience. Pathway analysis showed enrichment for miRNAs operating in pathways related to lysine degradation and fatty acid synthesis and metabolism. Finally, we demonstrated that the 12 resilience-related miRNAs differentially expressed in Braak Stages I\/II versus Braak Stages III\/IV were predicted to regulate mRNAs related to amyloid processing, tau and inflammation. In summary, we demonstrate a dynamic state wherein differential PCC miRNA levels are associated with cognitive performance and post-mortem neuropathological AD diagnostic criteria in cognitively intact elders. We posit these relationships may inform miRNA transcriptional alterations within the PCC relevant to potential early protective (resilience) or pathogenic (pre-clinical or prodromal) responses to disease pathogenesis and thus may be therapeutic targets.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae082","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T17:49:02Z","timestamp":1709660942000},"source":"Crossref","is-referenced-by-count":9,"title":["Micro-RNA profiles of pathology and resilience in posterior cingulate cortex of cognitively intact elders"],"prefix":"10.1093","volume":"6","author":[{"given":"Christy M","family":"Kelley","sequence":"first","affiliation":[{"name":"Department of Translational Neuroscience and Neurology, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center , Phoenix, AZ 85013 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Maloney","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Medical and Molecular Genetics, Indiana University School of Medicine , Indianapolis, IN 46202 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S","family":"Beck","sequence":"additional","affiliation":[{"name":"Departments of Translational Neuroscience and Family Medicine, Michigan State University College of Human Medicine , Grand Rapids, MI 49503 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D","family":"Ginsberg","sequence":"additional","affiliation":[{"name":"Center for Dementia Research, Nathan Kline Institute , Orangeburg, NY 10962 , USA"},{"name":"Departments of Psychiatry, Neuroscience & Physiology, and the NYU Neuroscience Institute, New York University Grossman School of Medicine , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-7735","authenticated-orcid":false,"given":"Winnie","family":"Liang","sequence":"additional","affiliation":[{"name":"Translational Genomics Research Institute , Phoenix, AZ 85004 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debomoy K","family":"Lahiri","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Medical and Molecular Genetics, Indiana University School of Medicine , Indianapolis, IN 46202 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4438-7334","authenticated-orcid":false,"given":"Elliott J","family":"Mufson","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience and Neurology, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center , Phoenix, AZ 85013 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2851-9763","authenticated-orcid":false,"given":"Scott E","family":"Counts","sequence":"additional","affiliation":[{"name":"Departments of Translational Neuroscience and Family Medicine, Michigan State University College of Human Medicine , Grand Rapids, MI 49503 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"issue":"1","key":"2024043010202378900_fcae082-B1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol"},{"issue":"5","key":"2024043010202378900_fcae082-B2","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/archneur.63.5.674","article-title":"Neuropathologic outcome of 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