{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:54:44Z","timestamp":1789779284607,"version":"4.0.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":71,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taiwan National Science and Technology Council","award":["112-2314-B-002-010"],"award-info":[{"award-number":["112-2314-B-002-010"]}]},{"name":"Taiwan National Science and Technology Council","award":["112-2923-B-002-001-MY3"],"award-info":[{"award-number":["112-2923-B-002-001-MY3"]}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["113-N0075"],"award-info":[{"award-number":["113-N0075"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["113-X0018"],"award-info":[{"award-number":["113-X0018"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tau, a hallmark of Alzheimer\u2019s disease, is poorly characterized in cerebral amyloid angiopathy. We aimed to assess the clinico-radiological correlations between tau positron emission tomography scans and cerebral amyloid angiopathy. We assessed cerebral amyloid and hyperphosphorylated tau in patients with probable cerebral amyloid angiopathy (n = 31) and hypertensive small vessel disease (n = 27) using 11C-Pittsburgh compound B and 18F-T807 positron emission tomography. Multivariable regression models were employed to assess radio-clinical features related to cerebral tau pathology in cerebral amyloid angiopathy. Cerebral amyloid angiopathy exhibited a higher cerebral tau burden in the inferior temporal lobe [1.25 (1.17\u20131.42) versus 1.08 (1.05\u20131.22), P &amp;lt; 0.001] and all Braak stage regions of interest (P &amp;lt; 0.05) than hypertensive small vessel disease, although the differences were attenuated after age adjustment. Cerebral tau pathology was significantly associated with cerebral amyloid angiopathy-related vascular markers, including cortical superficial siderosis (\u03b2 = 0.12, 95% confidence interval 0.04\u20130.21) and cerebral amyloid angiopathy score (\u03b2 = 0.12, 95% confidence interval 0.03\u20130.21) after adjustment for age, ApoE4 status and whole cortex amyloid load. Tau pathology correlated significantly with cognitive score (Spearman\u2019s \u03c1=\u22120.56, P = 0.001) and hippocampal volume (\u22120.49, P = 0.007), even after adjustment. In conclusion, tau pathology is more frequent in sporadic cerebral amyloid angiopathy than in hypertensive small vessel disease. Cerebral amyloid angiopathy-related vascular pathologies, especially cortical superficial siderosis, are potential markers of cerebral tau pathology suggestive of concomitant Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae086","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T06:32:46Z","timestamp":1710138766000},"source":"Crossref","is-referenced-by-count":16,"title":["Cerebral tau pathology in cerebral amyloid angiopathy"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4721-1468","authenticated-orcid":false,"given":"Hsin-Hsi","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Neurology, National Taiwan University Hospital , Taipei 100225 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ju","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, National Taiwan University Hospital , Taipei 100225 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Ching","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, National Taiwan University Hospital , Taipei 100225 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, National Taiwan University Hospital , Taipei 100225 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoh-Fang","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, National Taiwan University Hospital , Taipei 100225 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiann-Shing","family":"Jeng","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Taiwan University Hospital , Taipei 100225 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Kai","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Taiwan University Hospital , Taipei 100225 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"issue":"1","key":"2024043010174201200_fcae086-B1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1001\/archneur.63.1.148","article-title":"Cerebral amyloid angiopathy and lobar intracerebral hemorrhage","volume":"63","author":"Smith","year":"2006","journal-title":"Arch Neurol"},{"issue":"1","key":"2024043010174201200_fcae086-B2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","article-title":"Cerebral amyloid angiopathy and Alzheimer disease\u2014One peptide, two pathways","volume":"16","author":"Greenberg","year":"2020","journal-title":"Nat Rev 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