{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:55:45Z","timestamp":1791896145668,"version":"4.3.4"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":92,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministero Sviluppo Economico"},{"name":"Contratto di sviluppo industriale"},{"name":"Farmaceutica e Diagnostica","award":["000606"],"award-info":[{"award-number":["000606"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NextGenerationEU"},{"name":"Piano Nazionale di Ripresa e Resilienza"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Large-scale brain activity has long been investigated under the erroneous assumption of stationarity. Nowadays, we know that resting-state functional connectivity is characterized by aperiodic, scale-free bursts of activity (i.e. neuronal avalanches) that intermittently recruit different brain regions. These different patterns of activity represent a measure of brain flexibility, whose reduction has been found to predict clinical impairment in multiple neurodegenerative diseases such as Parkinson\u2019s disease, amyotrophic lateral sclerosis and Alzheimer\u2019s disease. Brain flexibility has been recently found increased in multiple sclerosis, but its relationship with clinical disability remains elusive. Also, potential differences in brain dynamics according to the multiple sclerosis clinical phenotypes remain unexplored so far. We performed a brain dynamics study quantifying brain flexibility utilizing the \u2018functional repertoire\u2019 (i.e. the number of configurations of active brain areas) through source reconstruction of magnetoencephalography signals in a cohort of 25 multiple sclerosis patients (10 relapsing\u2013remitting multiple sclerosis and 15 secondary progressive multiple sclerosis) and 25 healthy controls. Multiple sclerosis patients showed a greater number of unique reconfigurations at fast time scales as compared with healthy controls. This difference was mainly driven by the relapsing\u2013remitting multiple sclerosis phenotype, whereas no significant differences in brain dynamics were found between secondary progressive multiple sclerosis and healthy controls. Brain flexibility also showed a different predictive power on clinical disability according to the multiple sclerosis type. For the first time, we investigated brain dynamics in multiple sclerosis patients through high temporal resolution techniques, unveiling differences in brain flexibility according to the multiple sclerosis phenotype and its relationship with clinical disability.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae112","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T10:11:43Z","timestamp":1712052703000},"source":"Crossref","is-referenced-by-count":15,"title":["Flexibility of brain dynamics is increased and predicts clinical impairment in relapsing\u2013remitting but not in secondary progressive multiple sclerosis"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5651-4970","authenticated-orcid":false,"given":"Lorenzo","family":"Cipriano","sequence":"first","affiliation":[{"name":"Department of Medical, Motor and Wellness Sciences, University of Naples \u2018Parthenope\u2019 , 80133 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Minino","sequence":"additional","affiliation":[{"name":"Department of Medical, Motor and Wellness Sciences, University of Naples \u2018Parthenope\u2019 , 80133 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Liparoti","sequence":"additional","affiliation":[{"name":"Department of Philosophical, Pedagogical and Quantitative-Economic Sciences, University of Chieti-Pescara \u2018G. d\u2019Annunzio\u2019 , 66100 Chieti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Polverino","sequence":"additional","affiliation":[{"name":"Institute of Diagnosis and Therapy Hermitage Capodimonte , 80145 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Medical, Motor and Wellness Sciences, University of Naples \u2018Parthenope\u2019 , 80133 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Bonavita","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u2018L. Vanvitelli\u2019 , 81100 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-3513","authenticated-orcid":false,"given":"Maria Agnese","family":"Pirozzi","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u2018L. Vanvitelli\u2019 , 81100 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Quarantelli","sequence":"additional","affiliation":[{"name":"Biostructure and Bioimaging Institute, CNR , 80145 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Jirsa","sequence":"additional","affiliation":[{"name":"Institut de Neurosciences des Syst\u00e8mes, Inserm, INS, Aix-Marseille University , 13005 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0800-2433","authenticated-orcid":false,"given":"Giuseppe","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Department of Medical, Motor and Wellness Sciences, University of Naples \u2018Parthenope\u2019 , 80133 Naples , Italy"},{"name":"Institute of Diagnosis and Therapy Hermitage Capodimonte , 80145 Naples , Italy"},{"name":"Institute of Applied Sciences and Intelligent Systems, National Research Council , 80078 Pozzuoli , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-9800","authenticated-orcid":false,"given":"Pierpaolo","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Institut de Neurosciences des Syst\u00e8mes, Inserm, INS, Aix-Marseille University , 13005 Marseille , France"},{"name":"Department of Biomedical Sciences, University of Sassari , 07100 Sassari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emahnuel","family":"Troisi Lopez","sequence":"additional","affiliation":[{"name":"Institute of Applied Sciences and Intelligent Systems, National Research Council , 80078 Pozzuoli , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"issue":"JAN","key":"2024043010252409400_fcae112-B1","first-page":"1","article-title":"Pathogenic mechanisms associated with different 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