{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:05:20Z","timestamp":1793480720975,"version":"4.5.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":95,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-NS89757"],"award-info":[{"award-number":["R01-NS89757"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DC12519"],"award-info":[{"award-number":["R01-DC12519"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DC14942"],"award-info":[{"award-number":["R01-DC14942"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001068","name":"Dana Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001068","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Progressive supranuclear palsy is a neurodegenerative disease characterized by the deposition of four-repeat tau in neuronal and glial lesions in the brainstem, cerebellar, subcortical and cortical brain regions. There are varying clinical presentations of progressive supranuclear palsy with different neuroimaging signatures, presumed to be due to different topographical distributions and burden of tau. The classic Richardson syndrome presentation is considered a subcortical variant, whilst progressive supranuclear palsy with predominant speech and language impairment is considered a cortical variant, although the pathological underpinnings of these variants are unclear. In this case-control study, we aimed to determine whether patterns of regional tau pathology differed between these variants and whether tau burden correlated with neuroimaging. Thirty-three neuropathologically confirmed progressive supranuclear palsy patients with either the Richardson syndrome (n = 17) or speech\/language (n = 16) variant and ante-mortem magnetic resonance imaging were included. Tau lesion burden was semi-quantitatively graded in cerebellar, brainstem, subcortical and cortical regions and combined to form neuronal and glial tau scores. Regional magnetic resonance imaging volumes were converted to Z-scores using 33 age- and sex-matched controls. Diffusion tensor imaging metrics, including fractional anisotropy and mean diffusivity, were calculated. Tau burden and neuroimaging metrics were compared between groups and correlated using linear regression models. Neuronal and glial tau burden were higher in motor and superior frontal cortices in the speech\/language variant. In the subcortical and brainstem regions, only the glial tau burden differed, with a higher burden in globus pallidus, subthalamic nucleus, substantia nigra and red nucleus in Richardson\u2019s syndrome. No differences were observed in the cerebellar dentate and striatum. Greater volume loss was observed in the motor cortex in the speech\/language variant and in the subthalamic nucleus, red nucleus and midbrain in Richardson\u2019s syndrome. Fractional anisotropy was lower in the midbrain and superior cerebellar peduncle in Richardson\u2019s syndrome. Mean diffusivity was greater in the superior frontal cortex in the speech\/language variant and midbrain in Richardson\u2019s syndrome. Neuronal tau burden showed associations with volume loss, lower fractional anisotropy and higher mean diffusivity in the superior frontal cortex, although these findings did not survive correction for multiple comparisons. Results suggest that a shift in the distribution of tau, particularly neuronal tau, within the progressive supranuclear palsy network of regions is driving different clinical presentations in progressive supranuclear palsy. The possibility of different disease epicentres in these clinical variants has potential implications for the use of imaging biomarkers in progressive supranuclear palsy.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae113","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:13:27Z","timestamp":1712189607000},"source":"Crossref","is-referenced-by-count":12,"title":["Histologic tau lesions and magnetic resonance imaging biomarkers differ across two progressive supranuclear palsy variants"],"prefix":"10.1093","volume":"6","author":[{"given":"Francesca","family":"Orlandi","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"},{"name":"Department of Neurology and Neurophysiology, IRCCS San Raffaele University , Milan 20132 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2100-5033","authenticated-orcid":false,"given":"Arenn F","family":"Carlos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farwa","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8206-3432","authenticated-orcid":false,"given":"Joseph R","family":"Duffy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene L","family":"Utianski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-685X","authenticated-orcid":false,"given":"Hugo","family":"Botha","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M","family":"Machulda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehkyoung C","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1466-8357","authenticated-orcid":false,"given":"Christopher G","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L","family":"Senjem","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905 , USA"},{"name":"Department of Information Technology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7916-622X","authenticated-orcid":false,"given":"Clifford R","family":"Jack","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-4979","authenticated-orcid":false,"given":"Federica","family":"Agosta","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurophysiology, IRCCS San Raffaele University , Milan 20132 , Italy"},{"name":"Division of Neuroscience, Neuroimaging Research Unit, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute , Milan 20132 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5485-0479","authenticated-orcid":false,"given":"Massimo","family":"Filippi","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurophysiology, IRCCS San Raffaele University , Milan 20132 , Italy"},{"name":"Division of Neuroscience, Neuroimaging Research Unit, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute , Milan 20132 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7189-7917","authenticated-orcid":false,"given":"Dennis W","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic , Jacksonville, FL 32224 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-8634","authenticated-orcid":false,"given":"Keith A","family":"Josephs","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6914-1563","authenticated-orcid":false,"given":"Jennifer L","family":"Whitwell","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"2024042409525143800_fcae113-B1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/9781444341256.ch15","volume-title":"Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders","author":"Dickson","year":"2011","edition":"2nd edn"},{"issue":"4","key":"2024042409525143800_fcae113-B2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00401-022-02479-4","article-title":"Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy","volume":"144","author":"Roemer","year":"2022","journal-title":"Acta Neuropathol"},{"issue":"11","key":"2024042409525143800_fcae113-B3","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1212\/WNL.44.11.2015","article-title":"Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy)","volume":"44","author":"Hauw","year":"1994","journal-title":"Neurology"},{"issue":"4","key":"2024042409525143800_fcae113-B4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/WCO.0b013e32833be924","article-title":"Neuropathology of variants of progressive supranuclear palsy","volume":"23","author":"Dickson","year":"2010","journal-title":"Curr Opin Neurol"},{"key":"2024042409525143800_fcae113-B5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1001\/archneur.1964.00460160003001","article-title":"Progressive supranuclear palsy. a heterogeneous degeneration involving the brain stem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia","volume":"10","author":"Steele","year":"1964","journal-title":"Arch Neurol"},{"issue":"Pt 6","key":"2024042409525143800_fcae113-B6","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/brain\/awh488","article-title":"Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism","volume":"128","author":"Williams","year":"2005","journal-title":"Brain"},{"issue":"Pt 6","key":"2024042409525143800_fcae113-B7","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1093\/brain\/awm104","article-title":"Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome","volume":"130","author":"Williams","year":"2007","journal-title":"Brain"},{"issue":"15","key":"2024042409525143800_fcae113-B8","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1002\/mds.21698","article-title":"Pure akinesia with gait freezing: A third clinical phenotype of progressive supranuclear palsy","volume":"22","author":"Williams","year":"2007","journal-title":"Mov Disord"},{"issue":"4","key":"2024042409525143800_fcae113-B9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/01.jnen.0000218446.38158.61","article-title":"Atypical progressive supranuclear palsy with corticospinal tract degeneration","volume":"65","author":"Josephs","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"issue":"4","key":"2024042409525143800_fcae113-B10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/13554790590963004","article-title":"Atypical progressive supranuclear palsy underlying progressive apraxia of speech and nonfluent aphasia","volume":"11","author":"Josephs","year":"2005","journal-title":"Neurocase"},{"issue":"8","key":"2024042409525143800_fcae113-B11","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/mds.20478","article-title":"Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome","volume":"20","author":"Tsuboi","year":"2005","journal-title":"Mov Disord"},{"issue":"6","key":"2024042409525143800_fcae113-B12","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mds.26987","article-title":"Clinical diagnosis of progressive supranuclear palsy: The Movement Disorder Society criteria","volume":"32","author":"H\u00f6glinger","year":"2017","journal-title":"Mov Disord"},{"issue":"2","key":"2024042409525143800_fcae113-B13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000068502","article-title":"Progressive nonfluent aphasia and subsequent aphasic dementia associated with atypical progressive supranuclear palsy pathology","volume":"49","author":"Boeve","year":"2003","journal-title":"Eur Neurol"},{"issue":"6","key":"2024042409525143800_fcae113-B14","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/WCO.0b013e3283168ddd","article-title":"Apraxia of speech and nonfluent aphasia: A new clinical marker for corticobasal degeneration and progressive supranuclear palsy","volume":"21","author":"Josephs","year":"2008","journal-title":"Curr Opin Neurol"},{"issue":"Pt 5","key":"2024042409525143800_fcae113-B15","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1093\/brain\/aws032","article-title":"Characterizing a neurodegenerative syndrome: Primary progressive apraxia of speech","volume":"135","author":"Josephs","year":"2012","journal-title":"Brain"},{"issue":"11","key":"2024042409525143800_fcae113-B16","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"issue":"6","key":"2024042409525143800_fcae113-B17","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/mdc3.12796","article-title":"An evaluation of the progressive supranuclear palsy speech\/language variant","volume":"6","author":"Whitwell","year":"2019","journal-title":"Mov Disord Clin Pract"},{"key":"2024042409525143800_fcae113-B18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-3-7091-6641-3_11","volume-title":"The neuropathology of progressive supranuclear palsy","author":"Lantos","year":"1994"},{"issue":"2","key":"2024042409525143800_fcae113-B19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neurobiolaging.2006.09.019","article-title":"Voxel-based morphometry in autopsy proven PSP and CBD","volume":"29","author":"Josephs","year":"2008","journal-title":"Neurobiol Aging"},{"issue":"4","key":"2024042409525143800_fcae113-B20","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/j.1460-9568.2010.07304.x","article-title":"The in vivo distribution of brain tissue loss in Richardson's syndrome and PSP-parkinsonism: A VBM-DARTEL study","volume":"32","author":"Agosta","year":"2010","journal-title":"Eur J Neurosci"},{"issue":"1","key":"2024042409525143800_fcae113-B21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/archneur.63.1.81","article-title":"Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy","volume":"63","author":"Boxer","year":"2006","journal-title":"Arch Neurol"},{"issue":"11","key":"2024042409525143800_fcae113-B22","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/mds.21619","article-title":"Voxel based morphometry reveals specific gray matter changes in primary dystonia","volume":"22","author":"Egger","year":"2007","journal-title":"Mov Disord"},{"issue":"4","key":"2024042409525143800_fcae113-B23","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1212\/01.WNL.0000151854.85743.C7","article-title":"Quantitative MRI measurement of superior cerebellar peduncle in progressive supranuclear palsy","volume":"64","author":"Paviour","year":"2005","journal-title":"Neurology"},{"key":"2024042409525143800_fcae113-B24","doi-asserted-by":"crossref","first-page":"102152","DOI":"10.1016\/j.nicl.2019.102152","article-title":"Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants","volume":"25","author":"Whitwell","year":"2020","journal-title":"Neuroimage Clin"},{"issue":"9","key":"2024042409525143800_fcae113-B25","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1007\/s00415-020-10360-1","article-title":"Diffusion tensor imaging analysis in three progressive supranuclear palsy variants","volume":"268","author":"Whitwell","year":"2021","journal-title":"J Neurol"},{"issue":"8","key":"2024042409525143800_fcae113-B26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.parkreldis.2011.05.013","article-title":"Disrupted thalamocortical connectivity in PSP: A resting-state fMRI, DTI, and VBM study","volume":"17","author":"Whitwell","year":"2011","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"2024042409525143800_fcae113-B27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/mds.28822","article-title":"Autopsy validation of progressive supranuclear palsy-predominant speech\/language disorder criteria","volume":"37","author":"Hokelekli","year":"2022","journal-title":"Mov Disord"},{"issue":"3","key":"2024042409525143800_fcae113-B28","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac108","article-title":"Histologic lesion type correlates of magnetic resonance imaging biomarkers in four-repeat tauopathies","volume":"4","author":"Carlos","year":"2022","journal-title":"Brain Commun"},{"issue":"7","key":"2024042409525143800_fcae113-B29","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/brain\/awz122","article-title":"Neuropathological correlates of structural and functional imaging biomarkers in 4-repeat tauopathies","volume":"142","author":"Spina","year":"2019","journal-title":"Brain"},{"issue":"4","key":"2024042409525143800_fcae113-B30","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"issue":"11","key":"2024042409525143800_fcae113-B31","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1212\/WNL.55.11.1621","article-title":"The FAB: A Frontal Assessment Battery at bedside","volume":"55","author":"Dubois","year":"2000","journal-title":"Neurology"},{"issue":"1","key":"2024042409525143800_fcae113-B32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/mds.21198","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan","volume":"22","author":"Goetz","year":"2007","journal-title":"Mov Disord"},{"issue":"Pt 6","key":"2024042409525143800_fcae113-B33","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1093\/brain\/awm032","article-title":"A clinical rating scale for progressive supranuclear palsy","volume":"130","author":"Golbe","year":"2007","journal-title":"Brain"},{"issue":"6","key":"2024042409525143800_fcae113-B34","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/archneurol.2011.107","article-title":"Clinical correlates of white matter tract degeneration in progressive supranuclear palsy","volume":"68","author":"Whitwell","year":"2011","journal-title":"Arch Neurol"},{"issue":"5","key":"2024042409525143800_fcae113-B35","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1177\/1533317509343104","article-title":"The Northwestern Anagram Test: Measuring sentence production in primary progressive aphasia","volume":"24","author":"Weintraub","year":"2009","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"2024042409525143800_fcae113-B36","volume-title":"Boston Naming test","author":"Kaplan","year":"2001"},{"issue":"2","key":"2024042409525143800_fcae113-B37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1044\/2022_AJSLP-22-00148","article-title":"The Apraxia of Speech Rating Scale: Reliability, validity, and utility","volume":"32","author":"Duffy","year":"2023","journal-title":"Am J Speech Lang Pathol"},{"key":"2024042409525143800_fcae113-B38","volume-title":"Motor speech disorders e-book: Substrates, differential diagnosis, and management","author":"Duffy","year":"2019"},{"issue":"1","key":"2024042409525143800_fcae113-B39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol"},{"issue":"12","key":"2024042409525143800_fcae113-B40","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"issue":"1","key":"2024042409525143800_fcae113-B41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2990.1989.tb01146.x","article-title":"Cortical and subcortical argyrophilic grains characterize a disease associated with adult onset dementia","volume":"15","author":"Braak","year":"1989","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"4","key":"2024042409525143800_fcae113-B42","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"issue":"6","key":"2024042409525143800_fcae113-B43","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00401-009-0538-8","article-title":"Unified staging system for Lewy body disorders: Correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction","volume":"117","author":"Beach","year":"2009","journal-title":"Acta Neuropathol"},{"issue":"8-9","key":"2024042409525143800_fcae113-B44","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s007020050096","article-title":"Argyrophilic grain disease: Frequency of occurrence in different age categories and neuropathological diagnostic criteria","volume":"105","author":"Braak","year":"1998","journal-title":"J Neural Transm (Vienna)"},{"issue":"1","key":"2024042409525143800_fcae113-B45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-015-1509-x","article-title":"Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy","volume":"131","author":"Kovacs","year":"2016","journal-title":"Acta Neuropathol"},{"issue":"2","key":"2024042409525143800_fcae113-B46","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00401-020-02158-2","article-title":"Distribution patterns of tau pathology in progressive supranuclear palsy","volume":"140","author":"Kovacs","year":"2020","journal-title":"Acta Neuropathol"},{"key":"2024042409525143800_fcae113-B47","first-page":"P792","article-title":"[P2\u2013415]: The mayo clinic adult lifespan template: Better quantification across the lifespan","volume":"13","author":"Schwarz","year":"2017","journal-title":"Alzheimers Dement"},{"issue":"1","key":"2024042409525143800_fcae113-B48","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain","volume":"12","author":"Avants","year":"2008","journal-title":"Med Image Anal"},{"key":"2024042409525143800_fcae113-B49","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neuroimage.2017.05.015","article-title":"Toward defining deep brain stimulation targets in MNI space: A subcortical atlas based on multimodal MRI, histology and structural connectivity","volume":"170","author":"Ewert","year":"018","journal-title":"Neuroimage"},{"issue":"1","key":"2024042409525143800_fcae113-B50","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/mds.26834","article-title":"[(18) F]AV-1451 tau positron emission tomography in progressive supranuclear palsy","volume":"32","author":"Whitwell","year":"2017","journal-title":"Mov Disord"},{"key":"2024042409525143800_fcae113-B51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fninf.2014.00008","article-title":"Dipy, a library for the analysis of diffusion MRI data","volume":"8","author":"Garyfallidis","year":"2014","journal-title":"Front Neuroinform"},{"issue":"2","key":"2024042409525143800_fcae113-B52","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.neuroimage.2009.01.002","article-title":"Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: Application to normal elderly and Alzheimer's disease participants","volume":"46","author":"Oishi","year":"2009","journal-title":"Neuroimage. Jun"},{"key":"2024042409525143800_fcae113-B53","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-3462-1","volume-title":"Regression modeling strategies: With applications to linear models, logistic regression, and survival analysis","author":"Harrell","year":"2001"},{"issue":"2","key":"2024042409525143800_fcae113-B54","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcad048","article-title":"Uncovering spatiotemporal patterns of atrophy in progressive supranuclear palsy using unsupervised machine learning","volume":"5","author":"Scotton","year":"2023","journal-title":"Brain Commun"},{"issue":"Pt 6","key":"2024042409525143800_fcae113-B55","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1093\/brain\/awl078","article-title":"Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech","volume":"129","author":"Josephs","year":"2006","journal-title":"Brain"},{"issue":"7","key":"2024042409525143800_fcae113-B56","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/mds.27038","article-title":"Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?","volume":"32","author":"Whitwell","year":"2017","journal-title":"Mov Disord"},{"issue":"1-2","key":"2024042409525143800_fcae113-B57","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0022-510X(03)00014-5","article-title":"Study of the rostral midbrain atrophy in progressive supranuclear palsy","volume":"210","author":"Kato","year":"2003","journal-title":"J Neurol Sci"},{"issue":"4","key":"2024042409525143800_fcae113-B58","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/ana.26455","article-title":"Long-duration progressive supranuclear palsy: Clinical course and pathological underpinnings","volume":"92","author":"Lukic","year":"2022","journal-title":"Ann Neurol"},{"key":"2024042409525143800_fcae113-B59","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.parkreldis.2019.07.001","article-title":"Multimodal neuroimaging relationships in progressive supranuclear palsy","volume":"66","author":"Sintini","year":"2019","journal-title":"Parkinsonism Relat Disord"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcae113\/57163850\/fcae113.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/6\/2\/fcae113\/57317282\/fcae113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/6\/2\/fcae113\/57317282\/fcae113.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T09:53:41Z","timestamp":1713952421000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcae113\/7641051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcae113","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024]]},"article-number":"fcae113"}}