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The present research was designed to investigate the topological reorganization and classification performance of low-order functional connectivity (LOFC) and high-order functional connectivity (HOFC) networks in patients with presbycusis. Resting-state functional magnetic resonance imaging (Rs-fMRI) data were obtained in 60 patients with presbycusis and 50 matched healthy control subjects (HCs). LOFC and HOFC networks were then constructed, and the topological metrics obtained from the constructed networks were compared to evaluate topological differences in global, nodal network metrics, modularity and rich-club organization between patients with presbycusis and HCs. The use of HOFC profiles boosted presbycusis classification accuracy, sensitivity and specificity compared to that using LOFC profiles. The brain networks in both patients with presbycusis and HCs exhibited small-world properties within the given threshold range, and striking differences between groups in topological metrics were discovered in the constructed networks (LOFC and HOFC). NBS analysis identified a subnetwork involving 26 nodes and 23 signally altered internodal connections in patients with presbycusis in comparison to HCs in HOFC networks. This study highlighted the topological differences between LOFC and HOFC networks in patients with presbycusis, suggesting that HOFC profiles may help to further identify brain network abnormalities in presbycusis.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae119","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T11:55:50Z","timestamp":1712318150000},"source":"Crossref","is-referenced-by-count":6,"title":["Topological disruption of low- and high-order functional networks in presbycusis"],"prefix":"10.1093","volume":"6","author":[{"given":"Yixi","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, The Affiliated Lianyungang Hospital of Xuzhou Medical University , Lianyungang 222000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nanjing Yuhua Hospital, Yuhua Branch of Nanjing First Hospital , Nanjing 210006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Clinical Medical College, Yangzhou University , Yangzhou 225001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Clinical Medical College, Yangzhou University , Yangzhou 225001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song\u2019an","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinical Medical College, Yangzhou University , Yangzhou 225001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital, Nanjing Medical University , Nanjing 210006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Nanjing First Hospital, Nanjing Medical University , Nanjing 210006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Clinical Medical College, Yangzhou University , Yangzhou 225001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0468-6452","authenticated-orcid":false,"given":"Yu-Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital, Nanjing Medical University , Nanjing 210006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,6]]},"reference":[{"issue":"3","key":"2024043010262326500_fcae119-B1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1176\/appi.ajp.2017.17040423","article-title":"Sensation and psychiatry: linking age-related hearing loss to late-life depression and cognitive decline","volume":"175","author":"Rutherford","year":"2018","journal-title":"Am. 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