{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:49:54Z","timestamp":1777348194458,"version":"3.51.4"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":129,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG051412"],"award-info":[{"award-number":["U01 AG051412"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AG068054"],"award-info":[{"award-number":["U19 AG068054"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1 AG079519"],"award-info":[{"award-number":["RF1 AG079519"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adults with Down syndrome are less likely to have hypertension than neurotypical adults. However, whether blood pressure measures are associated with brain health and clinical outcomes in this population has not been studied in detail. Here, we assessed whether pulse pressure is associated with markers of cerebrovascular disease and is linked to a diagnosis of dementia in adults with Down syndrome via structural imaging markers of cerebrovascular disease and atrophy. The study included participants with Down syndrome from the Alzheimer\u2019s Disease - Down Syndrome study (n = 195, age = 50.6 \u00b1 7.2 years, 44% women, 18% diagnosed with dementia). Higher pulse pressure was associated with greater global, parietal and occipital white matter hyperintensity volume but not with enlarged perivascular spaces, microbleeds or infarcts. Using a structural equation model, we found that pulse pressure was associated with greater white matter hyperintensity volume, which in turn was related to increased neurodegeneration, and subsequent dementia diagnosis. Pulse pressure is an important determinant of brain health and clinical outcomes in individuals with Down syndrome despite the low likelihood of frank hypertension.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae157","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T08:50:22Z","timestamp":1715244622000},"source":"Crossref","is-referenced-by-count":2,"title":["A pathway linking pulse pressure to dementia in adults with Down syndrome"],"prefix":"10.1093","volume":"6","author":[{"given":"Batool","family":"Rizvi","sequence":"first","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory, University of California , Irvine, Irvine, CA 92697 , USA"},{"name":"Department of Neurobiology and Behavior, University of California , Irvine, Irvine, CA 92697 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-3547","authenticated-orcid":false,"given":"Patrick J","family":"Lao","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"},{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"},{"name":"Gertrude H. 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Sergievsky Center, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"},{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University , New York, NY 10032 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-8078","authenticated-orcid":false,"given":"Jose","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Silverman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California , Irvine, Orange, CA 92688 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira T","family":"Lott","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California , Irvine, Orange, CA 92688 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Mapstone","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California , Irvine, Irvine, CA 92697 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M","family":"Wilcock","sequence":"additional","affiliation":[{"name":"Department of Neurology, Indiana University School of Medicine , Indianapolis, IN 46202 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Head","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California, Irvine , Irvine, CA 92697 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Yassa","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory, University of California , Irvine, Irvine, CA 92697 , USA"},{"name":"Department of Neurobiology and Behavior, University of California , Irvine, Irvine, CA 92697 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam M","family":"Brickman","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"},{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University , New York, NY 10032 , USA"},{"name":"Gertrude H. 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