{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:15:51Z","timestamp":1772594151914,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":176,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018972","name":"Berlin School of Mind and Brain","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chronic inflammatory demyelinating polyneuropathy (CIDP) compromises functions of the peripheral nervous system (PNS). Recently, however, symptoms such as cognitive deficits, visual dysfunction and circadian disorders were reported, compatible with additional involvement of the central nervous system (CNS) in CIDP. Against this background, we were interested in the functional state of melanopsin-expressing retinal ganglion cells (mRGCs) as a potential biomarker for sleep\u2013wake abnormalities and CNS involvement in CIDP. Based on a chromatic pupillometry protocol, we examined the integrity of the melanopsin system in a prospective case\u2013control study in 20 persons with CIDP compared to 20 controls without CIDP. The results were referred to clinical measures of disease severity and sleep behaviour. Patients with CIDP had a significantly reduced melanopsin-mediated post-illumination pupil response (PIPR) compared to healthy controls (25% versus 36%; P &amp;lt; 0.01). This reduction correlated with disease severity (r = 0.478, P &amp;lt; 0.05). Further, patients with CIDP reported diminished sleep quality (P &amp;lt; 0.05); however, there was no significant correlation with the melanopsin-mediated PIPR. The results demonstrate an impairment of mRGC function related to CIDP. Since the PIPR reduction correlated with disease severity, it could be an easily available biomarker for CNS affection in CIDP, a condition defined as PNS disorder.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae206","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T20:36:08Z","timestamp":1719347768000},"source":"Crossref","is-referenced-by-count":5,"title":["Central involvement in peripheral disease: melanopsin pathway impairment in chronic inflammatory demyelinating polyneuropathy"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2992-1048","authenticated-orcid":false,"given":"Oliver L","family":"Steiner","sequence":"first","affiliation":[{"name":"Department of Neurology, Motor and Cognition Group, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Campus Benjamin Franklin (CBF) , 12203 Berlin , Germany"},{"name":"Berlin School of Mind and Brain, Humboldt-Universit\u00e4t zu Berlin , 10099 Berlin , Germany"},{"name":"Institute of Psychology, Humboldt-Universit\u00e4t zu Berlin , 10099 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Klostermann","sequence":"additional","affiliation":[{"name":"Department of Neurology, Motor and Cognition Group, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Campus Benjamin Franklin (CBF) , 12203 Berlin , Germany"},{"name":"Berlin School of Mind and Brain, Humboldt-Universit\u00e4t zu Berlin , 10099 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"issue":"11","key":"2024083010174721700_fcae206-B1","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1111\/ene.14959","article-title":"European Academy of Neurology\/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force\u2014Second revision","volume":"28","author":"Van den Bergh","year":"2021","journal-title":"Eur J Neurol"},{"issue":"23","key":"2024083010174721700_fcae206-B2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1212\/WNL.0000000000006625","article-title":"Ultrastructural mechanisms of macrophage-induced demyelination in CIDP","volume":"91","author":"Koike","year":"2018","journal-title":"Neurology"},{"issue":"12","key":"2024083010174721700_fcae206-B3","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1212\/01.WNL.0000148589.87107.9C","article-title":"Physical training and fatigue, fitness, and quality of life in Guillain-Barr\u00e9 syndrome and CIDP","volume":"63","author":"Garssen","year":"2004","journal-title":"Neurology"},{"issue":"1","key":"2024083010174721700_fcae206-B4","doi-asserted-by":"crossref","first-page":"e16053","DOI":"10.1111\/ene.16053","article-title":"Theory of mind and executive dysfunction in chronic inflammatory demyelinating polyneuropathy","volume":"31","author":"Lochmann","year":"2024","journal-title":"Eur J Neurol"},{"issue":"12","key":"2024083010174721700_fcae206-B5","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/S1388-2457(00)00478-8","article-title":"Visual evoked potentials study in chronic idiopathic inflammatory demyelinating polyneuropathy","volume":"111","author":"Stojkovic","year":"2000","journal-title":"Clin Neurophysiol"},{"issue":"1","key":"2024083010174721700_fcae206-B6","doi-asserted-by":"crossref","first-page":"e1099","DOI":"10.1212\/NXI.0000000000001099","article-title":"CNS involvement in chronic inflammatory demyelinating polyneuropathy: Subtle retinal changes in optical coherence tomography","volume":"9","author":"Ingwersen","year":"2022","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"5557","key":"2024083010174721700_fcae206-B7","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.1069609","article-title":"Melanopsin-containing retinal ganglion cells: Architecture, projections, and intrinsic photosensitivity","volume":"295","author":"Hattar","year":"2002","journal-title":"Science"},{"key":"2024083010174721700_fcae206-B8","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3389\/fneur.2018.01047","article-title":"Melanopsin retinal ganglion cells and pupil: Clinical implications for neuro-ophthalmology","volume":"9","author":"La Morgia","year":"2018","journal-title":"Front Neurol"},{"issue":"7","key":"2024083010174721700_fcae206-B9","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.visres.2006.12.015","article-title":"Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells","volume":"47","author":"Gamlin","year":"2007","journal-title":"Vis Res"},{"key":"2024083010174721700_fcae206-B10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fneur.2019.00129","article-title":"Standards in pupillography","volume":"10","author":"Kelbsch","year":"2019","journal-title":"Front Neurol"},{"issue":"9","key":"2024083010174721700_fcae206-B11","doi-asserted-by":"crossref","first-page":"6624","DOI":"10.1167\/iovs.11-7586","article-title":"Toward a clinical protocol for assessing rod, cone, and melanopsin contributions to the human pupil response","volume":"52","author":"Park","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"2024083010174721700_fcae206-B12","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1001\/jamaneurol.2016.5131","article-title":"Retinal architecture and melanopsin-mediated pupillary response characteristics: A putative pathophysiologic signature for the retino-hypothalamic tract in multiple sclerosis","volume":"74","author":"Meltzer","year":"2017","journal-title":"JAMA Neurol"},{"issue":"3","key":"2024083010174721700_fcae206-B13","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1468-1331.2009.02930.x","article-title":"European Federation of Neurological Societies\/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society\u2014First revision","volume":"17","author":"Van den Bergh","year":"2010","journal-title":"Eur J Neurol"},{"issue":"1","key":"2024083010174721700_fcae206-B14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0022-3999(97)00298-5","article-title":"Psychometric evaluation of the Pittsburgh Sleep Quality Index","volume":"45","author":"Carpenter","year":"1998","journal-title":"J Psychosom Res"},{"issue":"4","key":"2024083010174721700_fcae206-B15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1212\/WNL.0b013e318208824b","article-title":"Rasch-built Overall Disability Scale (R-ODS) for immune-mediated peripheral neuropathies","volume":"76","author":"van Nes","year":"2011","journal-title":"Neurology"},{"issue":"3","key":"2024083010174721700_fcae206-B16","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.autrev.2011.05.012","article-title":"Autoimmune disorders affecting both the central and peripheral nervous system","volume":"11","author":"Kamm","year":"2012","journal-title":"Autoimmun Rev"},{"issue":"10","key":"2024083010174721700_fcae206-B17","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S1474-4422(17)30278-8","article-title":"Retinal layer segmentation in multiple sclerosis: A systematic review and meta-analysis","volume":"16","author":"Petzold","year":"2017","journal-title":"Lancet Neurol"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcae206\/58329932\/fcae206.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/6\/4\/fcae206\/58888231\/fcae206.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/6\/4\/fcae206\/58888231\/fcae206.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T13:30:34Z","timestamp":1725024634000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcae206\/7698948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcae206","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024]]},"article-number":"fcae206"}}