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While epidemiological links between repeated traumatic brain injury and outcome have been investigated in humans, exploration of its mechanistic substrates has been largely undertaken in animal models. We compared acute neurological effects of repeat mild traumatic brain injury (n = 21) to that of single injury (n = 21) and healthy controls (n = 76) using resting-state functional MRI and quantified thalamic functional connectivity, given previous identification of its prognostic potential in human mild traumatic brain injury and rodent repeat mild traumatic brain injury. Acute thalamocortical functional connectivity showed a rank-based trend of increasing connectivity with number of injuries, at local and global scales of investigation. Thus, history of as few as two previous injuries can induce a vulnerable neural environment of exacerbated hyperconnectivity, in otherwise healthy individuals from non-specialist populations. These results further establish thalamocortical functional connectivity as a scalable marker of acute injury and long-term neural dysfunction following mild traumatic brain injury.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae223","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T22:41:43Z","timestamp":1719355303000},"source":"Crossref","is-referenced-by-count":3,"title":["Repeat traumatic brain injury exacerbates acute thalamic hyperconnectivity in humans"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-5905","authenticated-orcid":false,"given":"Rebecca E","family":"Woodrow","sequence":"first","affiliation":[{"name":"University Division of Anaesthesia, University of Cambridge , Cambridge CB2 0SP , UK"},{"name":"Department of Clinical Neurosciences, University of Cambridge , Cambridge CB2 0QQ , 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