{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:31:02Z","timestamp":1790785862604,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":192,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS097494"],"award-info":[{"award-number":["R01NS097494"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ionic imbalances and sodium channel dysfunction, well-known sequelae of traumatic brain injury (TBI), promote functional impairment in affected subjects. Therefore, non-invasive measurement of sodium concentrations using 23Na MRI has the potential to detect clinically relevant injury and predict persistent symptoms. Recently, we reported diffusely lower apparent total sodium concentrations (aTSC) in mild TBI patients compared to controls, as well as correlations between lower aTSC and worse clinical outcomes. The main goal of this study was to determine whether these aTSC findings, and their changes over time, predict outcomes at 3- and 12-month from injury. Twenty-seven patients previously studied with 23Na MRI and outcome measures at 22 \u00b1 10 days (average \u00b1 standard deviation) after injury (visit-1, v1) were contacted at 3- (visit-2, v2) and 12-month after injury (visit-3, v3) to complete the Rivermead post-concussion symptoms questionnaire (RPQ), the extended Glasgow outcome scale (GOSE), and the brief test of adult cognition by telephone (BTACT). Follow-up 1H and 23Na MRI were additionally scheduled at v2. Linear regression was used to calculate aTSC in global grey and white matters. Six hypotheses were tested in relation to the serial changes in outcome measures and in aTSC, and in relation to the cross-sectional and serial relationships between aTSC and outcome. Twenty patients contributed data at v2 and fifteen at v3. Total RPQ and composite BTACT z-scores differed significantly for v2 and v3 in comparison to v1 (each P &amp;lt; 0.01), reflecting longitudinally reduced symptomatology and improved performance on cognitive testing. No associations between aTSC and outcome were observed at v2. Previously lower grey and white matter aTSC normalized at v2 in comparison to controls, in line with a statistically detectable longitudinal increase in grey matter aTSC between v1 and v2 (P = 0.0004). aTSC values at v1 predicted a subset of future BTACT subtest scores, but not future RPQ scores nor GOSE-defined recovery status. Similarly, aTSC rates of change correlated with BTACT rates of change, but not with those of RPQ. Tissue aTSC, previously shown to be diffusely decreased compared to controls at v1, was no longer reduced by v2, suggesting normalization of the sodium ionic equilibrium. These changes were accompanied by marked improvement in outcome. The results support the notion that early aTSC from 23Na MRI predicts future BTACT, but not RPQ scores, nor future GOSE status.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae229","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T19:26:16Z","timestamp":1720725976000},"source":"Crossref","is-referenced-by-count":7,"title":["Longitudinal changes in sodium concentration and in clinical outcome in mild traumatic brain injury"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-4632","authenticated-orcid":false,"given":"Teresa","family":"Gerhalter","sequence":"first","affiliation":[{"name":"Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine , New York, NY 10016 , USA"},{"name":"Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8466-7536","authenticated-orcid":false,"given":"Anna M","family":"Chen","sequence":"additional","affiliation":[{"name":"Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine , New York, NY 10016 , USA"},{"name":"Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine , New York, NY 10016 , USA"},{"name":"Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seena","family":"Dehkharghani","sequence":"additional","affiliation":[{"name":"Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine , New York, NY 10016 , USA"},{"name":"Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine , New York, NY 10016 , USA"},{"name":"Department of Neurology, New York University Grossman School of Medicine , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Peralta","sequence":"additional","affiliation":[{"name":"Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine , New York, NY 10016 , USA"},{"name":"Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Gajdosik","sequence":"additional","affiliation":[{"name":"Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine , New York, NY 10016 , USA"},{"name":"Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Zarate","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, New York University Grossman School of Medicine , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Bushnik","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, New York University Grossman School of Medicine , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, New York University Grossman School of Medicine , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, New York University Grossman School of Medicine , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P","family":"Wall","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman Department of Emergency Medicine, New York University Grossman School of Medicine , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-5792","authenticated-orcid":false,"given":"Guillaume","family":"Madelin","sequence":"additional","affiliation":[{"name":"Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine , New York, NY 10016 , USA"},{"name":"Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine , New York, NY 10016 , USA"},{"name":"Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan I","family":"Kirov","sequence":"additional","affiliation":[{"name":"Bernard and Irene Schwartz Center for Biomedical 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