{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:29:28Z","timestamp":1792708168438,"version":"4.5.0"},"reference-count":118,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":189,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ricerca Corrente 2024 from Italian Ministry of Health"},{"name":"Western University Start-Up Package"},{"DOI":"10.13039\/100010564","name":"Academic Medical Organization of Southwestern Ontario","doi-asserted-by":"publisher","award":["#F23-001"],"award-info":[{"award-number":["#F23-001"]}],"id":[{"id":"10.13039\/100010564","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Western Strategic Support for Canadian Institutes of Health Research\u2014Success Seed Program"},{"DOI":"10.13039\/501100021202","name":"Digital Research Alliance of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with epilepsy are characterized by a dysregulation of excitation\/inhibition balance (E\/I). The assessment of E\/I may inform clinicians during the diagnosis and therapy management, even though it is rarely performed. An accessible measure of the E\/I of the brain represents a clinically relevant feature. Here, we exploited the exponent of the aperiodic component of the power spectrum of the electroencephalography (EEG) signal, as a non-invasive and cost-effective proxy of the E\/I balance. We recorded resting-state activity with high-density EEG from 67 patients with temporal lobe epilepsy and 35 controls. We extracted the exponent of the aperiodic fit of the power spectrum from source-reconstructed EEG and tested differences between patients with epilepsy and controls. Spearman\u2019s correlation was performed between the exponent and clinical variables (age of onset, epilepsy duration and neuropsychology) and cortical expression of epilepsy-related genes derived from the Allen Human Brain Atlas. Patients with temporal lobe epilepsy showed a significantly larger exponent, corresponding to inhibition-directed E\/I balance, in bilateral frontal and temporal regions. Lower E\/I in the left entorhinal and bilateral dorsolateral prefrontal cortices corresponded to a lower performance of short-term verbal memory. Limited to patients with temporal lobe epilepsy, we detected a significant correlation between the exponent and the cortical expression of GABRA1, GRIN2A, GABRD, GABRG2, KCNA2 and PDYN genes. EEG aperiodic exponent maps the E\/I balance non-invasively in patients with epilepsy and reveals a close relationship between altered E\/I patterns, cognition and genetics.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae231","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T17:02:49Z","timestamp":1720112569000},"source":"Crossref","is-referenced-by-count":49,"title":["Excitation\/Inhibition balance relates to cognitive function and gene expression in temporal lobe epilepsy: a high density EEG assessment with aperiodic exponent"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0778-3920","authenticated-orcid":false,"given":"Gian Marco","family":"Duma","sequence":"first","affiliation":[{"name":"Scientific Institute IRCCS E.Medea, Epilepsy and Clinical Neurophysiology Unit , 31015, Conegliano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Cuozzo","sequence":"additional","affiliation":[{"name":"Scientific Institute IRCCS E.Medea, Epilepsy and Clinical Neurophysiology Unit , 31015, Conegliano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Wilson","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University , Montreal, QC H3A 2B4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Danieli","sequence":"additional","affiliation":[{"name":"Scientific Institute IRCCS E.Medea, Epilepsy and Clinical Neurophysiology Unit , 31015, Conegliano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bonanni","sequence":"additional","affiliation":[{"name":"Scientific Institute IRCCS E.Medea, Epilepsy and Clinical Neurophysiology Unit , 31015, Conegliano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University , London N6A5C1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"issue":"5","key":"2024083010244905700_fcae231-B1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/brain\/110.5.1359","article-title":"Generator mechanisms of giant somatosensory evoked potentials in cortical reflex myoclonus","volume":"110","author":"Kakigi","year":"1987","journal-title":"Brain"},{"key":"2024083010244905700_fcae231-B2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.seizure.2016.11.003","article-title":"Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy","volume":"44","author":"Matsumoto","year":"2017","journal-title":"Seizure"},{"issue":"1","key":"2024083010244905700_fcae231-B3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/brain\/108.1.225","article-title":"Pathogenesis of giant somatosensory evoked potentials in progressive myoclonic epilepsy","volume":"108","author":"Shibasaki","year":"1985","journal-title":"Brain"},{"key":"2024083010244905700_fcae231-B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/9781118456989.ch1","volume-title":"Epilepsy","author":"Stafstrom","year":"2014"},{"key":"2024083010244905700_fcae231-B5","doi-asserted-by":"crossref","first-page":"RP91599","DOI":"10.7554\/eLife.91599.3","article-title":"Balance of activity during a critical period tunes a developing network","volume":"12","author":"Hunter","year":"2023","journal-title":"eLife"},{"issue":"9","key":"2024083010244905700_fcae231-B6","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1109\/TBME.2019.2963430","article-title":"Excitation and inhibition balance underlying epileptiform activity","volume":"67","author":"Liu","year":"2020","journal-title":"IEEE Trans Biomed Eng"},{"issue":"5","key":"2024083010244905700_fcae231-B7","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1152\/jn.00232.2012","article-title":"Seizures as imbalanced up states: Excitatory and inhibitory conductances during seizure-like events","volume":"109","author":"\u017diburkus","year":"2013","journal-title":"J Neurophysiol"},{"issue":"1","key":"2024083010244905700_fcae231-B8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.braindev.2019.07.006","article-title":"Action of antiepileptic drugs on neurons","volume":"42","author":"Kobayashi","year":"2020","journal-title":"Brain and Development"},{"issue":"s2","key":"2024083010244905700_fcae231-B9","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1111\/j.1528-1157.1995.tb05996.x","article-title":"Antiepileptic drug mechanisms of action","volume":"36","author":"Macdonald","year":"1995","journal-title":"Epilepsia"},{"issue":"11","key":"2024083010244905700_fcae231-B10","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/j.1528-1157.1999.tb02029.x","article-title":"The pharmacologic basis of antiepileptic drug action","volume":"40","author":"Rho","year":"1999","journal-title":"Epilepsia"},{"key":"2024083010244905700_fcae231-B11","doi-asserted-by":"crossref","first-page":"120158","DOI":"10.1016\/j.neuroimage.2023.120158","article-title":"Validating MEG source imaging of resting state oscillatory patterns with an intracranial EEG atlas","volume":"274","author":"Afnan","year":"2023","journal-title":"NeuroImage"},{"issue":"1","key":"2024083010244905700_fcae231-B12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-022-02218-z","article-title":"From mechanisms to markers: Novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans","volume":"12","author":"Ahmad","year":"2022","journal-title":"Transl Psychiatry"},{"key":"2024083010244905700_fcae231-B13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fncir.2013.00018","article-title":"The contribution of transcranial magnetic stimulation in the functional evaluation of microcircuits in human motor cortex","volume":"7","author":"Di Lazzaro","year":"2013","journal-title":"Front Neural Circuits"},{"issue":"1","key":"2024083010244905700_fcae231-B14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/hbm.23837","article-title":"Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method","volume":"39","author":"Pellegrino","year":"2018","journal-title":"Hum Brain Mapp"},{"issue":"2","key":"2024083010244905700_fcae231-B15","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brs.2024.01.004","article-title":"Assessing cortical excitability with electroencephalography: A pilot study with EEG-iTBS","volume":"17","author":"Pellegrino","year":"2024","journal-title":"Brain Stimul."},{"issue":"12","key":"2024083010244905700_fcae231-B16","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1038\/s41593-020-00744-x","article-title":"Parameterizing neural power spectra into periodic and aperiodic components","volume":"23","author":"Donoghue","year":"2020","journal-title":"Nat Neurosci"},{"key":"2024083010244905700_fcae231-B17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuroimage.2017.06.078","article-title":"Inferring synaptic excitation\/inhibition balance from field potentials","volume":"158","author":"Gao","year":"2017","journal-title":"NeuroImage"},{"issue":"38","key":"2024083010244905700_fcae231-B18","doi-asserted-by":"crossref","first-page":"13257","DOI":"10.1523\/JNEUROSCI.2332-14.2015","article-title":"Age-related changes in 1\/f neural electrophysiological noise","volume":"35","author":"Voytek","year":"2015","journal-title":"J Neurosci"},{"key":"2024083010244905700_fcae231-B19","doi-asserted-by":"crossref","first-page":"108122","DOI":"10.1016\/j.yebeh.2021.108122","article-title":"Temporal lobe epilepsy: A never-ending story","volume":"122","author":"Abarrategui","year":"2021","journal-title":"Epilepsy Behav"},{"key":"2024083010244905700_fcae231-B20","first-page":"e630853","article-title":"A review of the epidemiology of temporal lobe epilepsy","volume":"2012","author":"T\u00e9llez-Zenteno","year":"2011","journal-title":"Epilepsy Res Treat"},{"issue":"1","key":"2024083010244905700_fcae231-B21","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrd2997","article-title":"Key factors in the discovery and development of new antiepileptic drugs","volume":"9","author":"Bialer","year":"2010","journal-title":"Nat Rev Drug Discov"},{"issue":"8","key":"2024083010244905700_fcae231-B22","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/j.clinph.2020.05.022","article-title":"The effects of antiepileptic drugs on high-frequency oscillations in somatosensory evoked potentials","volume":"131","author":"Lanzone","year":"2020","journal-title":"Clin Neurophysiol"},{"issue":"7168","key":"2024083010244905700_fcae231-B23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature06289","article-title":"A synaptic memory trace for cortical receptive field plasticity","volume":"450","author":"Froemke","year":"2007","journal-title":"Nature"},{"issue":"5293","key":"2024083010244905700_fcae231-B24","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1126\/science.274.5293.1724","article-title":"Chaos in neuronal networks with balanced excitatory and inhibitory activity","volume":"274","author":"van Vreeswijk","year":"1996","journal-title":"Science"},{"key":"2024083010244905700_fcae231-B25","doi-asserted-by":"crossref","first-page":"112310","DOI":"10.1016\/j.bbr.2019.112310","article-title":"Potential causes of cognitive alterations in temporal lobe epilepsy","volume":"378","author":"Chauvi\u00e8re","year":"2020","journal-title":"Behav Brain Res"},{"key":"2024083010244905700_fcae231-B26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cortex.2022.08.010","article-title":"Resting state network dynamic reconfiguration and neuropsychological functioning in temporal lobe epilepsy: An HD-EEG investigation","volume":"157","author":"Duma","year":"2022","journal-title":"Cortex"},{"issue":"4","key":"2024083010244905700_fcae231-B27","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1111\/epi.16864","article-title":"Altered communication dynamics reflect cognitive deficits in temporal lobe epilepsy","volume":"62","author":"Girardi-Schappo","year":"2021","journal-title":"Epilepsia"},{"issue":"9","key":"2024083010244905700_fcae231-B28","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nn.3492","article-title":"Balanced cortical microcircuitry for maintaining information in working memory","volume":"16","author":"Lim","year":"2013","journal-title":"Nat Neurosci"},{"key":"2024083010244905700_fcae231-B29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/neuro.02.005.2008","article-title":"Epilepsy, E\/I balance and GABAA receptor plasticity","volume":"1","author":"Fritschy","year":"2008","journal-title":"Front Mol Neurosci"},{"key":"2024083010244905700_fcae231-B30","first-page":"4","article-title":"Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models","volume":"2","author":"Gatto","year":"2010","journal-title":"Front Synaptic Neurosci"},{"issue":"6","key":"2024083010244905700_fcae231-B31","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/ane.13695","article-title":"Potassium channels and epilepsy","volume":"146","author":"Gao","year":"2022","journal-title":"Acta Neurol Scand."},{"key":"2024083010244905700_fcae231-B32","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.3389\/fphar.2020.01276","article-title":"Epilepsy-related voltage-gated sodium channelopathies: A review","volume":"11","author":"Menezes","year":"2020","journal-title":"Front Pharmacol"},{"issue":"4","key":"2024083010244905700_fcae231-B33","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1177\/1073858418763752","article-title":"Potassium channel gain of function in epilepsy: An unresolved paradox","volume":"24","author":"Niday","year":"2018","journal-title":"Neuroscientist"},{"issue":"8","key":"2024083010244905700_fcae231-B34","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1111\/epi.17651","article-title":"Excitatory\/inhibitory balance in epilepsies and neurodevelopmental disorders: Depolarizing \u03b3-aminobutyric acid as a common mechanism","volume":"64","author":"van Hugte","year":"2023","journal-title":"Epilepsia"},{"key":"2024083010244905700_fcae231-B35","doi-asserted-by":"publisher","first-page":"e72129","DOI":"10.7554\/eLife.72129","article-title":"Standardizing workflows in imaging transcriptomics with the abagen toolbox","author":"Markello","year":"2021"},{"key":"2024083010244905700_fcae231-B36","doi-asserted-by":"crossref","first-page":"RP86933","DOI":"10.7554\/eLife.86933.3","article-title":"Transcriptional cartography integrates multiscale biology of the human cortex","volume":"12","author":"Wagstyl","year":"2023","journal-title":"eLife"},{"issue":"6","key":"2024083010244905700_fcae231-B37","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/epi.17240","article-title":"International league against epilepsy classification and definition of epilepsy syndromes with onset at a variable age: Position statement by the ILAE task force on nosology and definitions","volume":"63","author":"Riney","year":"2022","journal-title":"Epilepsia"},{"key":"2024083010244905700_fcae231-B38","volume-title":"Wechsler memory scale","author":"Wechsler","year":"1945"},{"issue":"6","key":"2024083010244905700_fcae231-B39","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s100720200003","article-title":"Rey-Osterrieth complex figure: Normative values in an Italian population sample","volume":"22","author":"Caffarra","year":"2002","journal-title":"Neurol Sci"},{"key":"2024083010244905700_fcae231-B40","volume-title":"Rey auditory verbal learning test: A handbook","author":"Schmidt","year":"1996"},{"issue":"4","key":"2024083010244905700_fcae231-B41","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF01997792","article-title":"Trail making test: Normative values from 287 normal adult controls","volume":"17","author":"Giovagnoli","year":"1996","journal-title":"Ital J Neuro Sci"},{"issue":"2","key":"2024083010244905700_fcae231-B42","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0361-476X(81)90035-7","article-title":"The psychometric tradition: Developing the Wechsler adult intelligence scale","volume":"6","author":"Wechsler","year":"1981","journal-title":"Contemp Educ Psychol"},{"issue":"5","key":"2024083010244905700_fcae231-B43","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/jir.12150","article-title":"Beyond the floor effect on the Wechsler intelligence scale for children\u20144th ed. (WISC-IV): Calculating IQ and indexes of subjects presenting a floored pattern of results","volume":"59","author":"Orsini","year":"2015","journal-title":"J Intellect Disabil Res"},{"issue":"1","key":"2024083010244905700_fcae231-B44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneumeth.2003.10.009","article-title":"EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis","volume":"134","author":"Delorme","year":"2004","journal-title":"J Neurosci Methods"},{"issue":"5","key":"2024083010244905700_fcae231-B45","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/epi.17551","article-title":"Altered spreading of neuronal avalanches in temporal lobe epilepsy relates to cognitive performance: A resting-state hdEEG study","volume":"64","author":"Duma","year":"2023","journal-title":"Epilepsia"},{"issue":"2","key":"2024083010244905700_fcae231-B46","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1364-6613(00)01813-1","article-title":"Independent component analysis: An introduction","volume":"6","author":"Stone","year":"2002","journal-title":"Trends Cogn Sci"},{"issue":"6","key":"2024083010244905700_fcae231-B47","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1162\/neco.1995.7.6.1129","article-title":"An information-maximization approach to blind separation and blind deconvolution","volume":"7","author":"Bell","year":"1995","journal-title":"Neural Comput."},{"issue":"2","key":"2024083010244905700_fcae231-B48","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0013-4694(89)90180-6","article-title":"Spherical splines for scalp potential and current density mapping","volume":"72","author":"Perrin","year":"1989","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"2","key":"2024083010244905700_fcae231-B49","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.neuroimage.2012.01.024","article-title":"Brain templates and atlases","volume":"62","author":"Evans","year":"2012","journal-title":"NeuroImage"},{"key":"2024083010244905700_fcae231-B50","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.neuroimage.2012.09.050","article-title":"Cortical thickness and central surface estimation","volume":"65","author":"Dahnke","year":"2013","journal-title":"NeuroImage"},{"key":"2024083010244905700_fcae231-B51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/879716","article-title":"Brainstorm: A user-friendly application for MEG\/EEG analysis","volume":"2011","author":"Tadel","year":"2011","journal-title":"Comput Intell Neurosci"},{"key":"2024083010244905700_fcae231-B52","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3389\/fnins.2013.00267","article-title":"MEG and EEG data analysis with MNE-python","volume":"7","author":"Gramfort","year":"2013","journal-title":"Front Neurosci"},{"issue":"1","key":"2024083010244905700_fcae231-B53","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1109\/TMI.2004.837363","article-title":"A common formalism for the integral formulations of the forward EEG problem","volume":"24","author":"Kybic","year":"2005","journal-title":"IEEE Trans Med Imaging"},{"issue":"1","key":"2024083010244905700_fcae231-B54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF02512476","article-title":"Interpreting magnetic fields of the brain: Minimum norm estimates","volume":"32","author":"H\u00e4m\u00e4l\u00e4inen","year":"1994","journal-title":"Med Biol Eng Comput"},{"issue":"3","key":"2024083010244905700_fcae231-B55","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"NeuroImage"},{"key":"2024083010244905700_fcae231-B56","doi-asserted-by":"crossref","first-page":"120424","DOI":"10.1016\/j.neuroimage.2023.120424","article-title":"The impact of ROI extraction method for MEG connectivity estimation: Practical recommendations for the study of resting state data","volume":"284","author":"Brki\u0107","year":"2023","journal-title":"NeuroImage"},{"issue":"7416","key":"2024083010244905700_fcae231-B57","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature11405","article-title":"An anatomically comprehensive atlas of the adult human brain transcriptome","volume":"489","author":"Hawrylycz","year":"2012","journal-title":"Nature"},{"key":"2024083010244905700_fcae231-B58","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuroimage.2019.01.011","article-title":"A practical guide to linking brain-wide gene expression and neuroimaging data","volume":"189","author":"Arnatkevic\u0306i\u016bt\u0117","year":"2019","journal-title":"NeuroImage"},{"issue":"4","key":"2024083010244905700_fcae231-B59","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/ng1032","article-title":"Microarray data normalization and transformation","volume":"32","author":"Quackenbush","year":"2002","journal-title":"Nat Genet"},{"issue":"83","key":"2024083010244905700_fcae231-B60","doi-asserted-by":"crossref","first-page":"20130048","DOI":"10.1098\/rsif.2013.0048","article-title":"Highly comparative time-series analysis: The empirical structure of time series and their methods","volume":"10","author":"Fulcher","year":"2013","journal-title":"J R Soc Interface"},{"key":"2024083010244905700_fcae231-B61","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.seizure.2016.11.030","article-title":"Epilepsy-associated genes","volume":"44","author":"Wang","year":"2017","journal-title":"Seizure"},{"issue":"12","key":"2024083010244905700_fcae231-B62","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.1469-8986.2011.01273.x","article-title":"Mass univariate analysis of event-related brain potentials\/fields I: A critical tutorial review","volume":"48","author":"Groppe","year":"2011","journal-title":"Psychophysiology"},{"issue":"5","key":"2024083010244905700_fcae231-B63","doi-asserted-by":"crossref","first-page":"e13786","DOI":"10.1111\/psyp.13786","article-title":"Event-related network changes unfold the dynamics of cortical integration during face processing","volume":"58","author":"Maffei","year":"2021","journal-title":"Psychophysiology"},{"issue":"1","key":"2024083010244905700_fcae231-B64","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Methodol"},{"issue":"7","key":"2024083010244905700_fcae231-B65","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41592-021-01186-4","article-title":"The ENIGMA toolbox: Multiscale neural contextualization of multisite neuroimaging datasets","volume":"18","author":"Larivi\u00e8re","year":"2021","journal-title":"Nat Methods"},{"issue":"1","key":"2024083010244905700_fcae231-B66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-021-02483-6","article-title":"The brain and its time: Intrinsic neural timescales are key for input processing","volume":"4","author":"Golesorkhi","year":"2021","journal-title":"Commun Biol"},{"issue":"1","key":"2024083010244905700_fcae231-B67","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1162\/netn_a_00270","article-title":"Dynamical interactions reconfigure the gradient of cortical timescales","volume":"7","author":"Sorrentino","year":"2023","journal-title":"Netw Neurosci"},{"issue":"12","key":"2024083010244905700_fcae231-B68","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1038\/nn.3862","article-title":"A hierarchy of intrinsic timescales across primate cortex","volume":"17","author":"Murray","year":"2014","journal-title":"Nat Neurosci"},{"issue":"4","key":"2024083010244905700_fcae231-B69","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/epi.17541","article-title":"Atypical intrinsic neural timescales in temporal lobe epilepsy","volume":"64","author":"Xie","year":"2023","journal-title":"Epilepsia"},{"key":"2024083010244905700_fcae231-B70","doi-asserted-by":"publisher","first-page":"e61277","DOI":"10.7554\/eLife.61277","article-title":"Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture","author":"Gao","year":"2020"},{"issue":"5045","key":"2024083010244905700_fcae231-B71","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1126\/science.1346729","article-title":"The influence of prior synaptic activity on the induction of long-term potentiation","volume":"255","author":"Huang","year":"1992","journal-title":"Science"},{"issue":"13","key":"2024083010244905700_fcae231-B72","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1523\/JNEUROSCI.5316-03.2004","article-title":"Preconditioning of low-frequency repetitive transcranial magnetic stimulation with transcranial direct current stimulation: Evidence for homeostatic plasticity in the human motor cortex","volume":"24","author":"Siebner","year":"2004","journal-title":"J Neurosci"},{"issue":"11","key":"2024083010244905700_fcae231-B73","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1111\/epi.12374","article-title":"The cortical excitability profile of temporal lobe epilepsy","volume":"54","author":"Badawy","year":"2013","journal-title":"Epilepsia"},{"issue":"4","key":"2024083010244905700_fcae231-B74","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1152\/jn.1999.82.4.2024","article-title":"Priming-induced shift in synaptic plasticity in the rat hippocampus","volume":"82","author":"Wang","year":"1999","journal-title":"J Neurophysiol"},{"key":"2024083010244905700_fcae231-B75","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fncel.2020.00197","article-title":"Homeostatic plasticity in epilepsy","volume":"14","author":"Lignani","year":"2020","journal-title":"Front Cell Neurosci"},{"issue":"9","key":"2024083010244905700_fcae231-B76","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.biopsych.2004.07.017","article-title":"Preconditioning with transcranial direct current stimulation sensitizes the motor cortex to rapid-rate transcranial magnetic stimulation and controls the direction of after-effects","volume":"56","author":"Lang","year":"2004","journal-title":"Biol Psychiatry"},{"issue":"3","key":"2024083010244905700_fcae231-B77","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.brs.2012.07.006","article-title":"Mobile phone emissions modulate brain excitability in patients with focal epilepsy","volume":"6","author":"Tombini","year":"2013","journal-title":"Brain Stimul"},{"issue":"6","key":"2024083010244905700_fcae231-B78","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1523\/JNEUROSCI.1371-20.2021","article-title":"Effects of altered excitation-inhibition balance on decision making in a cortical circuit model","volume":"42","author":"Lam","year":"2022","journal-title":"J Neurosci"},{"issue":"3","key":"2024083010244905700_fcae231-B79","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/brain\/awp012","article-title":"Verbal memory in mesial temporal lobe epilepsy: Beyond material specificity","volume":"132","author":"Saling","year":"2009","journal-title":"Brain"},{"issue":"15","key":"2024083010244905700_fcae231-B80","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1212\/WNL.0000000000001461","article-title":"Memory fMRI predicts verbal memory decline after anterior temporal lobe resection","volume":"84","author":"Sidhu","year":"2015","journal-title":"Neurology"},{"issue":"4","key":"2024083010244905700_fcae231-B81","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/ana.10133","article-title":"Verbal memory in left temporal lobe epilepsy: Evidence for task-related localization","volume":"51","author":"Weintrob","year":"2002","journal-title":"Ann Neurol"},{"key":"2024083010244905700_fcae231-B82","doi-asserted-by":"crossref","first-page":"790691","DOI":"10.3389\/fncir.2021.790691","article-title":"Cognitive networks (cognits) process and maintain working memory","volume":"15","author":"Fuster","year":"2022","journal-title":"Front Neural Circuits"},{"issue":"7","key":"2024083010244905700_fcae231-B83","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.tins.2022.04.006","article-title":"Construction of complex memories via parallel distributed cortical\u2013subcortical iterative integration","volume":"45","author":"McNaughton","year":"2022","journal-title":"Trends Neurosci"},{"issue":"42","key":"2024083010244905700_fcae231-B84","doi-asserted-by":"crossref","first-page":"10723","DOI":"10.1523\/JNEUROSCI.2344-16.2016","article-title":"The integration of distributed memory traces","volume":"36","author":"Wagner","year":"2016","journal-title":"J Neurosci"},{"key":"2024083010244905700_fcae231-B85","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuroimage.2017.01.062","article-title":"Retrieval of high-fidelity memory arises from distributed cortical networks","volume":"149","author":"Wais","year":"2017","journal-title":"NeuroImage"},{"issue":"12","key":"2024083010244905700_fcae231-B86","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41582-021-00555-z","article-title":"Neurobehavioural comorbidities of epilepsy: Towards a network-based precision taxonomy","volume":"17","author":"Hermann","year":"2021","journal-title":"Nat Rev Neurol"},{"key":"2024083010244905700_fcae231-B87","doi-asserted-by":"crossref","first-page":"107686","DOI":"10.1016\/j.yebeh.2020.107686","article-title":"Mechanisms of cognitive impairment in temporal lobe epilepsy: A systematic review of resting-state functional connectivity studies","volume":"115","author":"Ives-Deliperi","year":"2021","journal-title":"Epilepsy Behav."},{"issue":"9848","key":"2024083010244905700_fcae231-B88","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/S0140-6736(12)61455-X","article-title":"Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan","volume":"380","author":"Lin","year":"2012","journal-title":"Lancet"},{"issue":"44","key":"2024083010244905700_fcae231-B89","doi-asserted-by":"crossref","first-page":"E9366","DOI":"10.1073\/pnas.1705841114","article-title":"Balanced excitation and inhibition are required for high-capacity, noise-robust neuronal selectivity","volume":"114","author":"Rubin","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024083010244905700_fcae231-B90","doi-asserted-by":"publisher","first-page":"e62116","DOI":"10.7554\/eLife.62116","article-title":"Topographic gradients of intrinsic dynamics across neocortex","author":"Shafiei","year":"2020"},{"issue":"1","key":"2024083010244905700_fcae231-B91","doi-asserted-by":"crossref","first-page":"6000","DOI":"10.1038\/s41467-023-41689-6","article-title":"Neurophysiological signatures of cortical micro-architecture","volume":"14","author":"Shafiei","year":"2023","journal-title":"Nat Commun"},{"key":"2024083010244905700_fcae231-B92","doi-asserted-by":"crossref","first-page":"868342","DOI":"10.3389\/fnagi.2022.868342","article-title":"Subject-specific features of excitation\/inhibition profiles in neurodegenerative diseases","volume":"14","author":"Monteverdi","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"45","key":"2024083010244905700_fcae231-B93","doi-asserted-by":"crossref","first-page":"eabg8411","DOI":"10.1126\/sciadv.abg8411","article-title":"Excitatory-inhibitory balance modulates the formation and dynamics of neuronal assemblies in cortical networks","volume":"7","author":"Sadeh","year":"2021","journal-title":"Sci Adv"},{"issue":"4","key":"2024083010244905700_fcae231-B94","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1523\/JNEUROSCI.3733-05.2006","article-title":"A recurrent network mechanism of time integration in perceptual decisions","volume":"26","author":"Wong","year":"2006","journal-title":"J Neurosci"},{"issue":"10","key":"2024083010244905700_fcae231-B95","doi-asserted-by":"crossref","first-page":"107963","DOI":"10.1016\/j.isci.2023.107963","article-title":"Natural brain state change with E\/I balance shifting toward inhibition is associated with vigilance impairment","volume":"26","author":"Yang","year":"2023","journal-title":"iScience"},{"key":"2024083010244905700_fcae231-B96","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.seizure.2019.01.005","article-title":"Progressive myoclonus epilepsy caused by a gain-of-function KCNA2 mutation","volume":"65","author":"Canafoglia","year":"2019","journal-title":"Seizure"},{"issue":"9","key":"2024083010244905700_fcae231-B97","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1093\/brain\/awx184","article-title":"Clinical spectrum and genotype\u2013phenotype associations of KCNA2-related encephalopathies","volume":"140","author":"Masnada","year":"2017","journal-title":"Brain"},{"issue":"11","key":"2024083010244905700_fcae231-B98","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1111\/epi.14576","article-title":"\u03b3-Aminobutyric acid receptor alpha 1 subunit loss of function causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment","volume":"59","author":"Samarut","year":"2018","journal-title":"Epilepsia"},{"issue":"4","key":"2024083010244905700_fcae231-B99","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1124\/mol.112.083337","article-title":"Dynorphin\u2013still an extraordinarily potent opioid peptide","volume":"83","author":"Chavkin","year":"2013","journal-title":"Mol Pharmacol"},{"issue":"3","key":"2024083010244905700_fcae231-B100","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.pharmthera.2009.05.006","article-title":"30 years of dynorphins\u2014New insights on their functions in neuropsychiatric diseases","volume":"123","author":"Schwarzer","year":"2009","journal-title":"Pharmacol Ther"},{"issue":"2","key":"2024083010244905700_fcae231-B101","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/ana.10108","article-title":"A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy","volume":"51","author":"St\u00f6gmann","year":"2002","journal-title":"Ann Neurol"},{"issue":"4","key":"2024083010244905700_fcae231-B102","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/brain\/awab391","article-title":"Gain-of-function variants in GABRD reveal a novel pathway for neurodevelopmental disorders and epilepsy","volume":"145","author":"Ahring","year":"2022","journal-title":"Brain"},{"issue":"1","key":"2024083010244905700_fcae231-B103","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/brain\/awy304","article-title":"GRIN2A-related disorders: Genotype and functional consequence predict phenotype","volume":"142","author":"Strehlow","year":"2019","journal-title":"Brain"},{"issue":"4","key":"2024083010244905700_fcae231-B104","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ng.3239","article-title":"De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy","volume":"47","author":"Syrbe","year":"2015","journal-title":"Nat Genet"},{"issue":"1","key":"2024083010244905700_fcae231-B105","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1038\/ncomms4251","article-title":"Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy","volume":"5","author":"Yuan","year":"2014","journal-title":"Nat Commun"},{"issue":"11","key":"2024083010244905700_fcae231-B106","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/s41593-022-01186-3","article-title":"Mapping neurotransmitter systems to the structural and functional organization of the human neocortex","volume":"25","author":"Hansen","year":"2022","journal-title":"Nat Neurosci"},{"issue":"1","key":"2024083010244905700_fcae231-B107","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1038\/s41467-022-31730-5","article-title":"Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression","volume":"13","author":"Larivi\u00e8re","year":"2022","journal-title":"Nat Commun"},{"issue":"4","key":"2024083010244905700_fcae231-B108","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/ana.26871","article-title":"Alterations of cortical structure and neurophysiology in Parkinson\u2019s disease are aligned with neurochemical systems","volume":"95","author":"Wiesman","year":"2024","journal-title":"Ann Neurol"},{"issue":"1","key":"2024083010244905700_fcae231-B109","doi-asserted-by":"crossref","first-page":"21870","DOI":"10.1038\/s41598-022-26392-8","article-title":"Power spectrum and critical exponents in the 2D stochastic Wilson\u2013Cowan model","volume":"12","author":"Apicella","year":"2022","journal-title":"Sci Rep"},{"issue":"3","key":"2024083010244905700_fcae231-B110","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/1550059416652055","article-title":"Slow activity in focal epilepsy during sleep and wakefulness","volume":"48","author":"Pellegrino","year":"2017","journal-title":"Clin EEG Neurosci"},{"issue":"3","key":"2024083010244905700_fcae231-B111","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1528-1167.2010.02918.x","article-title":"Interictal regional delta slowing is an EEG marker of epileptic network in temporal lobe epilepsy","volume":"52","author":"Tao","year":"2011","journal-title":"Epilepsia"},{"issue":"4","key":"2024083010244905700_fcae231-B112","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1212\/WNL.27.4.326","article-title":"Brain lesions that produce delta waves in the EEG","volume":"27","author":"Gloor","year":"1977","journal-title":"Neurology"},{"issue":"6","key":"2024083010244905700_fcae231-B113","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.clinph.2014.09.029","article-title":"Wakefulness delta waves increase after cortical plasticity induction","volume":"126","author":"Assenza","year":"2015","journal-title":"Clin Neurophysiol"},{"issue":"4","key":"2024083010244905700_fcae231-B114","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/brain\/awx017","article-title":"Altered sleep homeostasis correlates with cognitive impairment in patients with focal epilepsy","volume":"140","author":"Boly","year":"2017","journal-title":"Brain"},{"issue":"12","key":"2024083010244905700_fcae231-B115","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1093\/brain\/awq316","article-title":"Impaired consciousness in temporal lobe seizures: Role of cortical slow activity","volume":"133","author":"Englot","year":"2010","journal-title":"Brain"},{"issue":"5","key":"2024083010244905700_fcae231-B116","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1528-1167.2005.11404.x","article-title":"Intracranial EEG substrates of scalp EEG interictal spikes","volume":"46","author":"Tao","year":"2005","journal-title":"Epilepsia"},{"key":"2024083010244905700_fcae231-B117","doi-asserted-by":"crossref","first-page":"709400","DOI":"10.3389\/fneur.2021.709400","article-title":"Multimodal image integration for epilepsy presurgical evaluation: A clinical workflow","volume":"12","author":"Jin","year":"2021","journal-title":"Front Neurol"},{"key":"2024083010244905700_fcae231-B118","article-title":"Long-term intracranial EEG lateralization of epileptogenicity in patients with confirmed or suspected bilateral mesial temporal lobe onsets during epilepsy surgical evaluation","author":"Arain","year":"2023","journal-title":"J Clin Neurophysiol"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcae231\/58473737\/fcae231.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/6\/4\/fcae231\/58888487\/fcae231.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/6\/4\/fcae231\/58888487\/fcae231.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T09:33:02Z","timestamp":1725010382000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcae231\/7709387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":118,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcae231","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.02.01.578441","asserted-by":"object"}]},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024]]},"article-number":"fcae231"}}