{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:38:22Z","timestamp":1788208702374,"version":"build-2803163510"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":234,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23 NS121401-01A1"],"award-info":[{"award-number":["K23 NS121401-01A1"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health Grant","doi-asserted-by":"crossref","award":["T32NS091006"],"award-info":[{"award-number":["T32NS091006"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Georgia Clinical and Translational Science Awards","award":["UL1TR002378"],"award-info":[{"award-number":["UL1TR002378"]}]},{"name":"Georgia Clinical and Translational Science Awards","award":["KL2TR002381"],"award-info":[{"award-number":["KL2TR002381"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS116504"],"award-info":[{"award-number":["R01 NS116504"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS125137"],"award-info":[{"award-number":["R01 NS125137"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R61 NS125568"],"award-info":[{"award-number":["R61 NS125568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Patients with drug-resistant temporal lobe epilepsy often undergo intracranial EEG recording to capture multiple seizures in order to lateralize the seizure onset zone. This process is associated with morbidity and often ends in postoperative seizure recurrence. Abundant interictal (between-seizure) data are captured during this process, but these data currently play a small role in surgical planning. Our objective was to predict the laterality of the seizure onset zone using interictal intracranial EEG data in patients with temporal lobe epilepsy. We performed a retrospective cohort study (single-centre study for model development; two-centre study for model validation). We studied patients with temporal lobe epilepsy undergoing intracranial EEG at the University of Pennsylvania (internal cohort) and the Medical University of South Carolina (external cohort) between 2015 and 2022. We developed a logistic regression model to predict seizure onset zone laterality using several interictal EEG features derived from recent publications. We compared the concordance between the model-predicted seizure onset zone laterality and the side of surgery between patients with good and poor surgical outcomes. Forty-seven patients (30 female; ages 20\u201369; 20 left-sided, 10 right-sided and 17 bilateral seizure onsets) were analysed for model development and internal validation. Nineteen patients (10 female; ages 23\u201373; 5 left-sided, 10 right-sided, 4 bilateral) were analysed for external validation. The internal cohort cross-validated area under the curve for a model trained using spike rates was 0.83 for a model predicting left-sided seizure onset and 0.68 for a model predicting right-sided seizure onset. Balanced accuracies in the external cohort were 79.3% and 78.9% for the left- and right-sided predictions, respectively. The predicted concordance between the laterality of the seizure onset zone and the side of surgery was higher in patients with good surgical outcome. We replicated the finding that right temporal lobe epilepsy was harder to distinguish in a separate modality of resting-state functional MRI. In conclusion, interictal EEG signatures are distinct across seizure onset zone lateralities. Left-sided seizure onsets are easier to distinguish than right-sided onsets. A model trained on spike rates accurately identifies patients with left-sided seizure onset zones and predicts surgical outcome. A potential clinical application of these findings could be to either support or oppose a hypothesis of unilateral temporal lobe epilepsy when deciding to pursue surgical resection or ablation as opposed to device implantation.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae284","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T23:46:56Z","timestamp":1724370416000},"source":"Crossref","is-referenced-by-count":10,"title":["Interictal intracranial EEG asymmetry lateralizes temporal lobe epilepsy"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-1817","authenticated-orcid":false,"given":"Erin C","family":"Conrad","sequence":"first","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]},{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9439-735X","authenticated-orcid":false,"given":"Alfredo","family":"Lucas","sequence":"additional","affiliation":[{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]},{"name":"Department of Bioengineering, School of Engineering & Applied Sciences, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]},{"name":"Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William K S","family":"Ojemann","sequence":"additional","affiliation":[{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]},{"name":"Department of Bioengineering, School of Engineering & Applied Sciences, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A","family":"Aguila","sequence":"additional","affiliation":[{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]},{"name":"Department of Bioengineering, School of Engineering & Applied Sciences, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Mojena","sequence":"additional","affiliation":[{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3697-9965","authenticated-orcid":false,"given":"Joshua J","family":"LaRocque","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]},{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-1685","authenticated-orcid":false,"given":"Akash R","family":"Pattnaik","sequence":"additional","affiliation":[{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]},{"name":"Department of Bioengineering, School of Engineering & Applied Sciences, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1789-9142","authenticated-orcid":false,"given":"Ryan","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]},{"name":"Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Greenblatt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis , St. Louis, MO 63110 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Tranquille","sequence":"additional","affiliation":[{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Parashos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of South Carolina , Charleston, SC 29425 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-4146","authenticated-orcid":false,"given":"Ezequiel","family":"Gleichgerrcht","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University , Atlanta, GA 30325 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Bonilha","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University , Atlanta, GA 30325 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Litt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]},{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]},{"name":"Department of Bioengineering, School of Engineering & Applied Sciences, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-6731","authenticated-orcid":false,"given":"Saurabh R","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyle","family":"Ungar","sequence":"additional","affiliation":[{"name":"Department of Computer and Information Science, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-6480","authenticated-orcid":false,"given":"Kathryn A","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]},{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"issue":"5","key":"2024103011284048000_fcae284-B1","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1212\/WNL.51.5.1256","article-title":"Is the underlying cause of epilepsy a major prognostic factor for recurrence?","volume":"51","author":"Semah","year":"1998","journal-title":"Neurology"},{"key":"2024103011284048000_fcae284-B2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.yebeh.2016.02.031","article-title":"Epilepsy monitoring unit length of stay","volume":"58","author":"Gazzola","year":"2016","journal-title":"Epilepsy Behav"},{"issue":"5","key":"2024103011284048000_fcae284-B3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2176\/nmc.ra.2015-0319","article-title":"Invasive evaluations for epilepsy surgery: A review of the literature","volume":"56","author":"Enatsu","year":"2016","journal-title":"Neurol Med Chir"},{"issue":"6","key":"2024103011284048000_fcae284-B4","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/epi.13010","article-title":"Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography","volume":"56","author":"King-Stephens","year":"2015","journal-title":"Epilepsia"},{"issue":"11","key":"2024103011284048000_fcae284-B5","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1111\/epi.13090","article-title":"The number of seizures needed in the EMU","volume":"56","author":"Struck","year":"2015","journal-title":"Epilepsia"},{"issue":"10","key":"2024103011284048000_fcae284-B6","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2176\/nmc.ra.2016-0186","article-title":"Non-invasive evaluation for epilepsy surgery","volume":"56","author":"Iwasaki","year":"2016","journal-title":"Neurol Med Chir"},{"issue":"7","key":"2024103011284048000_fcae284-B7","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1528-1157.1999.tb00794.x","article-title":"Prediction of surgical outcome by interictal epileptiform abnormalities during intracranial EEG monitoring in patients with extrahippocampal seizures","volume":"40","author":"Bautista","year":"1999","journal-title":"Epilepsia"},{"issue":"6","key":"2024103011284048000_fcae284-B8","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1002\/acn3.51337","article-title":"Interictal spike networks predict surgical outcome in patients with drug-resistant focal epilepsy","volume":"8","author":"Azeem","year":"2021","journal-title":"Ann Clin Transl Neurol"},{"issue":"6","key":"2024103011284048000_fcae284-B9","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1528-1167.2010.02567.x","article-title":"Extent of neocortical resection and surgical outcome of epilepsy: Intracranial EEG analysis","volume":"51","author":"Kim","year":"2010","journal-title":"Epilepsia"},{"issue":"7","key":"2024103011284048000_fcae284-B10","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.jfma.2020.11.001","article-title":"Quantitative analysis of intraoperative electrocorticography mirrors histopathology and seizure outcome after epileptic surgery in children","volume":"120","author":"Peng","year":"2021","journal-title":"J Formos Med Assoc"},{"issue":"6","key":"2024103011284048000_fcae284-B11","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1093\/brain\/awab480","article-title":"Normative intracranial EEG maps epileptogenic tissues in focal epilepsy","volume":"145","author":"Bernabei","year":"2022","journal-title":"Brain"},{"issue":"3","key":"2024103011284048000_fcae284-B12","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/brain\/awab380","article-title":"Normative brain mapping of interictal intracranial EEG to localize epileptogenic tissue","volume":"145","author":"Taylor","year":"2022","journal-title":"Brain"},{"issue":"12","key":"2024103011284048000_fcae284-B13","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1111\/epi.16377","article-title":"NREM sleep is the state of vigilance that best identifies the epileptogenic zone in the interictal electroencephalogram","volume":"60","author":"Klimes","year":"2019","journal-title":"Epilepsia"},{"issue":"10","key":"2024103011284048000_fcae284-B14","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1089\/brain.2021.0190","article-title":"Interictal functional connectivity in focal refractory epilepsies investigated by intracranial EEG","volume":"12","author":"Lagarde","year":"2022","journal-title":"Brain Connect"},{"issue":"10","key":"2024103011284048000_fcae284-B15","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.clinph.2019.07.024","article-title":"Multi-feature localization of epileptic foci from interictal, intracranial EEG","volume":"130","author":"Cimbalnik","year":"2019","journal-title":"Clin Neurophysiol"},{"issue":"4","key":"2024103011284048000_fcae284-B16","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/epi.17539","article-title":"Relative entropy is an easy-to-use invasive electroencephalographic biomarker of the epileptogenic zone","volume":"64","author":"Travnicek","year":"2023","journal-title":"Epilepsia"},{"issue":"9","key":"2024103011284048000_fcae284-B17","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/j.1528-1157.1999.tb00857.x","article-title":"Quantitative EEG analyses and surgical outcome after corpus callosotomy","volume":"40","author":"Matsuzaka","year":"1999","journal-title":"Epilepsia"},{"key":"2024103011284048000_fcae284-B18","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1528-1157.2001.4220282.x","article-title":"Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery","volume":"42","author":"Wieser","year":"2001","journal-title":"Epilepsia"},{"issue":"8","key":"2024103011284048000_fcae284-B19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1212\/WNL.43.8.1612","article-title":"Update on surgical treatment of the epilepsies","volume":"43","author":"Engel","year":"1993","journal-title":"Neurology"},{"issue":"2","key":"2024103011284048000_fcae284-B20","doi-asserted-by":"crossref","first-page":"026057","DOI":"10.1088\/1741-2552\/ac6829","article-title":"SleepSEEG: Automatic sleep scoring using intracranial EEG recordings only","volume":"19","author":"von Ellenrieder","year":"2022","journal-title":"J Neural Eng"},{"issue":"5","key":"2024103011284048000_fcae284-B21","doi-asserted-by":"crossref","first-page":"056019","DOI":"10.1088\/1741-2552\/ac90ed","article-title":"Addressing spatial bias in intracranial EEG functional connectivity analyses for epilepsy surgical planning","volume":"19","author":"Conrad","year":"2022","journal-title":"J Neural Eng"},{"issue":"7","key":"2024103011284048000_fcae284-B22","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/epi.16580","article-title":"Interictal intracranial electroencephalography for predicting surgical success: The importance of space and time","volume":"61","author":"Wang","year":"2020","journal-title":"Epilepsia"},{"issue":"2","key":"2024103011284048000_fcae284-B23","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1093\/brain\/awz386","article-title":"Spatial distribution of interictal spikes fluctuates over time and localizes seizure onset","volume":"143","author":"Conrad","year":"2020","journal-title":"Brain"},{"issue":"4","key":"2024103011284048000_fcae284-B24","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1093\/brain\/awy035","article-title":"Atlas of the normal intracranial electroencephalogram: Neurophysiological awake activity in different cortical areas","volume":"141","author":"Frauscher","year":"2018","journal-title":"Brain"},{"issue":"3","key":"2024103011284048000_fcae284-B25","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/jnr.24748","article-title":"Intracranial recordings reveal ubiquitous in-phase and in-antiphase functional connectivity between homotopic brain regions in humans","volume":"99","author":"O\u2019Reilly","year":"2021","journal-title":"J Neurosci Res"},{"issue":"8","key":"2024103011284048000_fcae284-B26","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.clinph.2007.04.017","article-title":"Comparison of novel computer detectors and human performance for spike detection in intracranial EEG","volume":"118","author":"Brown","year":"2007","journal-title":"Clin Neurophysiol"},{"issue":"8","key":"2024103011284048000_fcae284-B27","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1111\/epi.17663","article-title":"Temporal stability of intracranial electroencephalographic abnormality maps for localizing epileptogenic tissue","volume":"64","author":"Wang","year":"2023","journal-title":"Epilepsia"},{"key":"2024103011284048000_fcae284-B28","author":"Esteller"},{"issue":"3","key":"2024103011284048000_fcae284-B29","doi-asserted-by":"crossref","first-page":"e0193691","DOI":"10.1371\/journal.pone.0193691","article-title":"Detection of epileptic seizure based on entropy analysis of short-term EEG","volume":"13","author":"Li","year":"2018","journal-title":"PLoS One"},{"issue":"12","key":"2024103011284048000_fcae284-B30","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1093\/brain\/awz303","article-title":"Virtual resection predicts surgical outcome for drug-resistant epilepsy","volume":"142","author":"Kini","year":"2019","journal-title":"Brain"},{"key":"2024103011284048000_fcae284-B31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chaos.2014.06.010","article-title":"Multifractal detrended cross-correlation analysis for epileptic patient in seizure and seizure free status","volume":"67","author":"Ghosh","year":"2014","journal-title":"Chaos Solitons Fractals"},{"issue":"6","key":"2024103011284048000_fcae284-B32","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.brs.2023.11.005","article-title":"Resting-state background features demonstrate multidien cycles in long-term EEG device recordings","volume":"16","author":"Ojemann","year":"2023","journal-title":"Brain Stimul"},{"issue":"5","key":"2024103011284048000_fcae284-B33","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/epi.17565","article-title":"Resting state functional connectivity demonstrates increased segregation in bilateral temporal lobe epilepsy","volume":"64","author":"Lucas","year":"2023","journal-title":"Epilepsia"},{"issue":"8","key":"2024103011284048000_fcae284-B34","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1093\/cercor\/bhw157","article-title":"The human brainnetome atlas: A new brain atlas based on connectional architecture","volume":"26","author":"Fan","year":"2016","journal-title":"Cereb Cortex"},{"issue":"3","key":"2024103011284048000_fcae284-B35","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/epi.17482","article-title":"Spike patterns surrounding sleep and seizures localize the seizure-onset zone in focal epilepsy","volume":"64","author":"Conrad","year":"2023","journal-title":"Epilepsia"},{"issue":"1","key":"2024103011284048000_fcae284-B36","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol"},{"issue":"6","key":"2024103011284048000_fcae284-B37","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.3171\/2018.2.JNS171873","article-title":"Laser ablation for mesial temporal epilepsy: A multi-site, single institutional series","volume":"130","author":"Grewal","year":"2018","journal-title":"J Neurosurg"},{"issue":"2","key":"2024103011284048000_fcae284-B38","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/epi.13284","article-title":"Laser interstitial thermal therapy for medically intractable mesial temporal lobe epilepsy","volume":"57","author":"Kang","year":"2016","journal-title":"Epilepsia"},{"issue":"1","key":"2024103011284048000_fcae284-B39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neuroimage.2007.02.028","article-title":"Abnormalities of language networks in temporal lobe epilepsy","volume":"36","author":"Powell","year":"2007","journal-title":"Neuroimage"},{"issue":"2","key":"2024103011284048000_fcae284-B40","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1212\/WNL.30.2.120","article-title":"Interictal memory and language impairment in temporal lobe epilepsy","volume":"30","author":"Mayeux","year":"1980","journal-title":"Neurology"},{"key":"2024103011284048000_fcae284-B41","doi-asserted-by":"crossref","first-page":"103418","DOI":"10.1016\/j.nicl.2023.103418","article-title":"Subcortical functional connectivity gradients in temporal lobe epilepsy","volume":"38","author":"Lucas","year":"2023","journal-title":"Neuroimage Clin"},{"key":"2024103011284048000_fcae284-B42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.nicl.2014.07.013","article-title":"Connectivity and tissue microstructural alterations in right and left temporal lobe epilepsy revealed by diffusion spectrum imaging","volume":"5","author":"Lemkaddem","year":"2014","journal-title":"Neuroimage Clin"},{"issue":"Pt 8","key":"2024103011284048000_fcae284-B43","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1093\/brain\/aws137","article-title":"Structural substrates for resting network disruption in temporal lobe epilepsy","volume":"135","author":"Voets","year":"2012","journal-title":"Brain"},{"issue":"2","key":"2024103011284048000_fcae284-B44","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1212\/WNL.0b013e318205d521","article-title":"Increased temporolimbic cortical folding complexity in temporal lobe epilepsy","volume":"76","author":"Voets","year":"2011","journal-title":"Neurology"},{"issue":"9","key":"2024103011284048000_fcae284-B45","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1212\/WNL.43.9.1800","article-title":"MRI hippocampal volumes and memory function before and after temporal lobectomy","volume":"43","author":"Trenerry","year":"1993","journal-title":"Neurology"},{"issue":"8","key":"2024103011284048000_fcae284-B46","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/epi.14514","article-title":"Unilateral temporal interictal epileptiform discharges correctly predict the epileptogenic zone in lesional temporal lobe epilepsy","volume":"59","author":"Vollmar","year":"2018","journal-title":"Epilepsia"},{"issue":"5","key":"2024103011284048000_fcae284-B47","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1053\/seiz.2000.0414","article-title":"The lateralizing and surgical prognostic value of a single 2-hour EEG in mesial TLE","volume":"9","author":"Lee","year":"2000","journal-title":"Seizure"},{"issue":"6","key":"2024103011284048000_fcae284-B48","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1528-1157.1998.tb01431.x","article-title":"Predictive value of interictal epileptiform discharges during non-REM sleep on scalp EEG recordings for the lateralization of epileptogenesis","volume":"39","author":"Adachi","year":"1998","journal-title":"Epilepsia"},{"issue":"5","key":"2024103011284048000_fcae284-B49","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1528-1157.2000.tb00210.x","article-title":"Interictal EEG and ictal scalp EEG propagation are highly predictive of surgical outcome in mesial temporal lobe epilepsy","volume":"41","author":"Schulz","year":"2000","journal-title":"Epilepsia"},{"issue":"4","key":"2024103011284048000_fcae284-B50","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1001\/archneur.57.4.497","article-title":"Is ictal recording mandatory in temporal lobe epilepsy? Not when the interictal electroencephalogram and hippocampal atrophy coincide","volume":"57","author":"Cendes","year":"2000","journal-title":"Arch Neurol"},{"issue":"1","key":"2024103011284048000_fcae284-B51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41467-017-02577-y","article-title":"Multi-day rhythms modulate seizure risk in epilepsy","volume":"9","author":"Baud","year":"2018","journal-title":"Nat Commun"},{"issue":"Pt 4","key":"2024103011284048000_fcae284-B52","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/brain\/aww019","article-title":"Interictal spikes and epileptic seizures: Their relationship and underlying rhythmicity","volume":"139","author":"Karoly","year":"2016","journal-title":"Brain"},{"issue":"1","key":"2024103011284048000_fcae284-B53","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1001\/jamaneurol.2019.3485","article-title":"Development of expert-level automated detection of epileptiform discharges during electroencephalogram interpretation","volume":"77","author":"Jing","year":"2020","journal-title":"JAMA Neurol"},{"issue":"1","key":"2024103011284048000_fcae284-B54","doi-asserted-by":"crossref","first-page":"11137","DOI":"10.1038\/s41598-022-15147-0","article-title":"Focal epilepsy disrupts spindle structure and function","volume":"12","author":"Schiller","year":"2022","journal-title":"Sci Rep"},{"issue":"3","key":"2024103011284048000_fcae284-B55","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1684\/epd.2013.0587","article-title":"Cognitive outcomes of different surgical approaches in temporal lobe epilepsy","volume":"15","author":"Helmstaedter","year":"2013","journal-title":"Epileptic Disord"},{"issue":"6","key":"2024103011284048000_fcae284-B56","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1212\/01.WNL.0000048203.23766.A1","article-title":"Early and late cognitive changes following temporal lobe surgery for epilepsy","volume":"60","author":"Rausch","year":"2003","journal-title":"Neurology"},{"issue":"7","key":"2024103011284048000_fcae284-B57","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/epi.14443","article-title":"Laser ablation for mesial temporal lobe epilepsy: Surgical and cognitive outcomes with and without mesial temporal sclerosis","volume":"59","author":"Donos","year":"2018","journal-title":"Epilepsia"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcae284\/58892498\/fcae284.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/6\/5\/fcae284\/59865415\/fcae284.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/6\/5\/fcae284\/59865415\/fcae284.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T15:44:39Z","timestamp":1730303079000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcae284\/7739025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9,2]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcae284","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024]]},"article-number":"fcae284"}}