{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:11:32Z","timestamp":1790255492698,"version":"4.1.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":263,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche Medicale","doi-asserted-by":"publisher","award":["ING20140129160"],"award-info":[{"award-number":["ING20140129160"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Agence Nationale de la Recherche-Retour postdoctorant 2010"},{"name":"Conseil Regional Basse Normandie"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alcohol use disorder is a chronic disease characterized by an inappropriate pattern of drinking, resulting in negative consequences for the individual's physical, mental and social health. Korsakoff's syndrome is a complication of alcohol use disorder and is characterized by severe memory and executive deficits. The fronto-cerebellar and Papez circuits are structurally affected in patients with alcohol use disorder with and without Korsakoff\u2019s syndrome. The first objective of the present study was to measure the effect of chronic and excessive alcohol consumption on resting-state functional connectivity of these two functional brain networks. The second objective was to identify, for the first time, resting-state functional connectivity abnormalities specific to amnesic patients with Korsakoff\u2019s syndrome. In the present study, a neuropsychological assessment and a resting-state functional magnetic resonance imaging examination were conducted in 31 healthy controls (43.6 \u00b1 6.1 years) and 46 patients (46.6 \u00b1 9.1 years) with alcohol use disorder including 14 patients with Korsakoff\u2019s syndrome (55.5 \u00b1 5.3 years) to examine the effect of chronic and heavy alcohol consumption on functional connectivity of the fronto-cerebellar and the Papez circuits at rest and the specificity of functional connectivity changes in Korsakoff\u2019s syndrome compared to alcohol use disorder without Korsakoff\u2019s syndrome. The resting-state functional connectivity analyses focused on the nodes of the fronto-cerebellar and Papez circuits and combined region of interest and graph theory approaches, and whether these alterations are associated with the neuropsychological profile. In patients pooled together compared to controls, lower global efficiency was observed in the fronto-cerebellar circuit. In addition, certain regions of the fronto-cerebellar and Papez circuits were functionally hyperconnected at rest, which positively correlated with executive functions. Patients with Korsakoff\u2019s syndrome showed lower resting-state functional connectivity, lower local and global efficiency within the Papez circuit compared to those without Korsakoff\u2019s syndrome. Resting-state functional connectivity positively correlated with several cognitive scores in patients with Korsakoff\u2019s syndrome. The fronto-cerebellar and Papez circuits, two normally well-segregated networks, are functionally altered by alcohol use disorder. The Papez circuit attempts to compensate for deficits in the fronto-cerebellar circuit, albeit insufficiently as evidenced by patients\u2019 overall lower cognitive performance. Korsakoff\u2019s syndrome is characterized by altered functional connectivity in the Papez circuit known to be centrally involved in memory.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae294","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T13:49:31Z","timestamp":1726840171000},"source":"Crossref","is-referenced-by-count":4,"title":["Compensation patterns and altered functional connectivity in alcohol use disorder with and without Korsakoff's syndrome"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4498-6209","authenticated-orcid":false,"given":"Alexandrine","family":"Morand","sequence":"first","affiliation":[{"name":"Normandie Universit\u00e9, UNICAEN, INSERM, U1237, PhIND \u2018Physiopathology and Imaging of Neurological Disorders\u2019, Team NeuroPresage, Institut Blood and Brain @ Caen-Normandie, Cyceron , 14000 Caen ,","place":["France"]},{"name":"Laboratoire DysCo, Universit\u00e9 Paris 8 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