{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:45:42Z","timestamp":1753875942035,"version":"3.41.2"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":254,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1005492"],"award-info":[{"award-number":["1005492"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000943","name":"Commonwealth Scientific and Industrial Research Organisation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000943","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008716","name":"Science and Industry Endowment Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008716","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mental Health Research Institute"},{"DOI":"10.13039\/501100001001","name":"Alzheimer's Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Ageing Research Institute"},{"DOI":"10.13039\/501100020211","name":"Austin Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020211","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CogState Limited"},{"name":"Hollywood Private Hospital"},{"name":"Sir Charles Gardner Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dementia is a burgeoning global problem. Novel magnetic resonance imaging (MRI) metrics beyond volumetry may bring new insight and aid clinical trial evaluation of interventions early in the Alzheimer\u2019s disease course to complement existing imaging and clinical metrics. To determine whether: (i) normalized regional sodium-MRI values (Na-SI) are better predictors of neurocognitive status than volumetry (ii) cerebral amyloid PET status improves modelling. Nondemented older adult (&amp;gt;60 years) volunteers of known Alzheimer's Disease Assessment Scale (ADAS-Cog11), Mini-Mental State Examination (MMSE) and Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neurocognitive test scores, ApolipoproteinE (APOE) e4 +\/\u2212 cerebral amyloid PET status were prospectively recruited for 3T sodium-MRI brain scans. Left and right hippocampal, entorhinal and precuneus volumes and Na-SI (using the proportional intensity scaling normalization method with field inhomogeneity and partial volume corrections) were obtained after segmentation and co-registration of 3D-T1-weighted proton images. Descriptive statistics, correlation and best-subset regression analyses were performed. In our 76 nondemented participants (mean(standard deviation) age 75(5) years; woman 47(62%); cognitively unimpaired 54\/76(71%), mildly cognitively impaired 22\/76(29%)), left hippocampal Na-SI, not volume, was preferentially in the best models for predicting MMSE (Odds Ratio (OR) = 0.19(Confidence Interval (CI) = 0.07,0.53), P-value = 0.001) and ADAS-Cog11 (Beta(B) = 1.2(CI = 0.28,2.1), P-value = 0.01) scores. In the entorhinal analysis, right entorhinal Na-SI, not volume, was preferentially selected in the best model for predicting ADAS-Cog11 (B = 0.94(CI = 0.11,1.8), P-value = 0.03). While right entorhinal Na-SI and volume were both selected for MMSE modelling (Na-SI OR = 0.23(CI = 0.09,0.6), P-value = 0.003; volume OR = 2.6(CI = 1.0,6.6), P-value = 0.04), independently, Na-SI explained more of the variance (Na-SI R2 = 10.3; volume R2 = 7.5). No imaging variable was selected in the best CERAD models. Adding cerebral amyloid status improved model fit (Akaike Information Criterion increased 2.0 for all models, P-value &amp;lt; 0.001\u20130.045). Regional Na-SI were more predictive of MMSE and ADAS-Cog11 scores in our nondemented older adult cohort than volume, hippocampal more robust than entorhinal region of interest. Positive amyloid status slightly further improved model fit.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae307","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T22:41:56Z","timestamp":1726094516000},"source":"Crossref","is-referenced-by-count":0,"title":["3T sodium-MRI as predictor of neurocognition in nondemented older adults: a cross sectional study"],"prefix":"10.1093","volume":"6","author":[{"given":"Elaine","family":"Lui","sequence":"first","affiliation":[{"name":"Department of Radiology, The University of Melbourne , Parkville, 3050 Victoria ,","place":["Australia"]},{"name":"Department of Medical Imaging, The Royal Melbourne Hospital , Parkville, 3050 Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay K","family":"Venkatraman","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Melbourne , Parkville, 3050 Victoria ,","place":["Australia"]},{"name":"Department of Medical Imaging, The Royal Melbourne Hospital , Parkville, 3050 Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4261-0504","authenticated-orcid":false,"given":"Sue","family":"Finch","sequence":"additional","affiliation":[{"name":"Statistical Consulting Centre, University of Melbourne , Parkville, 3010 Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, The Royal Melbourne Hospital , Parkville, 3050 Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tie-Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, Karolinska Institute , 171 77 Stockholm ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-0408","authenticated-orcid":false,"given":"Bradley P","family":"Sutton","sequence":"additional","affiliation":[{"name":"Beckman Institute for Advance Science and Technology, University of Illinois at Urbana Champaign , Champaign, IL 61801 ,","place":["USA"]},{"name":"Department of Bioengineering, University of Illinois at Urbana-Champaign , Champaign, IL 61820 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher E","family":"Steward","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Melbourne , Parkville, 3050 Victoria ,","place":["Australia"]},{"name":"Department of Medical Imaging, The Royal Melbourne Hospital , Parkville, 3050 Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradford","family":"Moffat","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Melbourne , Parkville, 3050 Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth V","family":"Cyarto","sequence":"additional","affiliation":[{"name":"Australian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work, Faculty of Health, Queensland University of Technology , Brisbane, Queensland 4059 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn A","family":"Ellis","sequence":"additional","affiliation":[{"name":"Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne , Melbourne, 3010 Victoria ,","place":["Australia"]},{"name":"Melbourne School of Psychological Sciences, University of Melbourne , Melbourne, 3010 Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Therapy, Austin Health , Melbourne, 3084 Victoria ,","place":["Australia"]},{"name":"The Florey Institute of Neuroscience and Mental Health, The University of Melbourne , Melbourne, 3052 Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-7940","authenticated-orcid":false,"given":"Colin L","family":"Masters","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, The University of Melbourne , Melbourne, 3052 Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola T","family":"Lautenschlager","sequence":"additional","affiliation":[{"name":"Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne , Melbourne, 3010 Victoria ,","place":["Australia"]},{"name":"Royal Melbourne Hospital Mental Health Service, Royal Melbourne Hospital, Parkville , Melbourne, 3052 Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia M","family":"Desmond","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Melbourne , Parkville, 3050 Victoria ,","place":["Australia"]},{"name":"Department of Medical Imaging, The Royal Melbourne Hospital , Parkville, 3050 Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"issue":"10113","key":"2024103011320344400_fcae307-B1","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1016\/S0140-6736(17)31756-7","article-title":"Prevention and management of dementia: A priority for public 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