{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:01:35Z","timestamp":1789174895431,"version":"build-2803163510"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":283,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS058487"],"award-info":[{"award-number":["R01 NS058487"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 NS082168"],"award-info":[{"award-number":["T32 NS082168"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>It is established that one of the best predictors of a future diagnosis of Parkinson\u2019s disease is a current diagnosis of rapid eye movement behaviour disorder (RBD). In such patients, this provides a unique opportunity to study brain physiology and behavioural motor features of RBD that may precede early-stage Parkinson\u2019s disease. Based on prior work in early-stage Parkinson\u2019s disease, we aim to determine if the function of corticostriatal and cerebellar regions are impaired in RBD using task-based functional MRI and if structural changes can be detected within the caudate, putamen and substantia nigra in RBD using free-water imaging. To assess motor function, we measured performance on the Purdue Pegboard Test, which is affected in patients with RBD and Parkinson\u2019s disease. A cohort of 24 RBD, 39 early-stage Parkinson\u2019s disease and 25 controls were investigated. All participants were imaged at 3\u2005Telsa. Individuals performed a unimanual grip force task during functional imaging. Participants also completed scales to assess cognition, sleep and motor symptoms. We found decreased functional activity in both RBD and Parkinson\u2019s disease within the motor cortex, caudate, putamen and thalamus compared with controls. There was elevated free-water-corrected fractional anisotropy in the putamen in RBD and Parkinson\u2019s disease and elevated free-water in the putamen and posterior substantia nigra in Parkinson\u2019s disease compared with controls. Participants with RBD and Parkinson\u2019s disease performed significantly worse on all tasks of the Purdue Pegboard Test compared with controls. The both hands task of the Purdue Pegboard Test was most sensitive in distinguishing between groups. A subgroup analysis of early-stage RBD (&amp;lt;2 years diagnosis) confirmed similar findings as those in the larger RBD group. These findings provide new evidence that the putamen is affected in early-stage RBD using both functional and free-water imaging. We also found evidence that the striatum, thalamus and motor cortex have reduced functional activity in early-stage RBD and Parkinson\u2019s disease. While the substantia nigra shows elevated free-water in Parkinson\u2019s disease, we did not observe this effect in early-stage RBD. These findings point to the corticostriatal and thalamocortical circuits being impaired in RBD patients.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae344","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T18:12:56Z","timestamp":1728583976000},"source":"Crossref","is-referenced-by-count":14,"title":["Functional and free-water imaging in rapid eye movement behaviour disorder and Parkinson\u2019s disease"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-7207","authenticated-orcid":false,"given":"Emily R","family":"Tobin","sequence":"first","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida , Gainesville, FL 32611 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Arpin","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida , Gainesville, FL 32611 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa B","family":"Schauder","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida , Gainesville, FL 32611 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara L","family":"Higgonbottham","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida , Gainesville, FL 32611 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Florida , Gainesville, FL 32603 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiangYang","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Florida , Gainesville, FL 32603 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care and Sleep, University of Florida , Gainesville, FL 32610 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos A","family":"Christou","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida , Gainesville, FL 32611 ,","place":["USA"]},{"name":"Department of Biomedical Engineering, University of Florida , Gainesville, FL 32603 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Jaffee","sequence":"additional","affiliation":[{"name":"Fixel Institute for Neurological Disease, University of Florida , Gainesville, FL 32608 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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