{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:16:05Z","timestamp":1787008565958,"version":"build-2736575974"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":295,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013295","name":"Helmholtz Zentrum M\u00fcnchen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013295","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Federal Ministry of Education and Research"},{"name":"State of Bavaria"},{"DOI":"10.13039\/501100015675","name":"Munich Center of Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015675","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ludwig-Maximilians-Universita\u0308"},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>First small sample studies indicate that disturbances of spinal morphology may impair craniospinal flow of cerebrospinal fluid and result in neurodegeneration. The aim of this study was to evaluate the association of cervical spinal canal width and scoliosis with grey matter, white matter, ventricular and white matter hyperintensity volumes of the brain in a large study sample. Four hundred participants underwent whole-body 3 T magnetic resonance imaging. Grey matter, white matter and ventricular volumes were quantified using a warp-based automated brain volumetric approach. Spinal canal diameters were measured manually at the cervical vertebrae 2\/3 level. Scoliosis was evaluated using manual measurements of the Cobb angle. Linear binomial regression analyses of measures of brain volumes and spine anatomy were performed while adjusting for age, sex, hypertension, cholesterol levels, body mass index, smoking and alcohol consumption. Three hundred eighty-three participants were included [57% male; age: 56.3 (\u00b19.2) years]. After adjustment, smaller spinal canal width at the cervical vertebrae 2\/3 level was associated with lower grey matter (P = 0.034), lower white matter (P = 0.012) and higher ventricular (P = 0.006, inverse association) volume. Participants with scoliosis had lower grey matter (P = 0.005), lower white matter (P = 0.011) and larger brain ventricular (P = 0.003) volumes than participants without scoliosis. However, these associations were attenuated after adjustment. Spinal canal width at the cervical vertebrae 2\/3 level and scoliosis were not associated with white matter hyperintensity volume before and after adjustment (P &amp;gt; 0.864). In our study, cohort smaller spinal canal width at the cervical vertebrae 2\/3 level and scoliosis were associated with lower grey and white matter volumes and larger ventricle size. These characteristics of the spine might constitute independent risk factors for neurodegeneration.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae365","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T12:37:54Z","timestamp":1729600674000},"source":"Crossref","is-referenced-by-count":2,"title":["The spine-brain axis: is spinal anatomy associated with brain volume?"],"prefix":"10.1093","volume":"6","author":[{"given":"Sergio","family":"Grosu","sequence":"first","affiliation":[{"name":"Department of Radiology, LMU University Hospital, LMU Munich , 81377 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trayana","family":"Nikolova","sequence":"additional","affiliation":[{"name":"Department of Radiology, LMU University Hospital, LMU Munich , 81377 Munich 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Neuherberg ,","place":["Germany"]},{"name":"KORA Study Centre, University Hospital of Augsburg , 86153 Augsburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena S","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University of Tuebingen , 72076 Tuebingen ,","place":["Germany"]},{"name":"Department of Nuclear Medicine and Clinical Molecular Imaging, University of Tuebingen , 72076 Tuebingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department for Trauma and Reconstructive Surgery, BG Unfallklinik Tuebingen, University of Tuebingen , 72076 Tuebingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven S","family":"Walter","sequence":"additional","affiliation":[{"name":"KORA Study Centre, University Hospital of Augsburg , 86153 Augsburg ,","place":["Germany"]},{"name":"Department of Radiology, Division of Musculoskeletal Radiology, New York University, Grossman School of Medicine , New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7896-7049","authenticated-orcid":false,"given":"Birgit B","family":"Ertl-Wagner","sequence":"additional","affiliation":[{"name":"Department of Radiology, LMU University Hospital, LMU Munich , 81377 Munich ,","place":["Germany"]},{"name":"Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto , Toronto, ON , , M5G 1E8","place":["Canada"]},{"name":"Department of Medical Imaging, University of Toronto , Toronto, ON , , M5T 1W7","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Ricke","sequence":"additional","affiliation":[{"name":"Department of Radiology, LMU University Hospital, LMU Munich , 81377 Munich 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