{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:11:30Z","timestamp":1787317890124,"version":"build-2736575974"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030692","name":"Intramural Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. 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Lesioned and control tissue was co-labelled with antibody markers for cell identity, proliferation, and apoptosis (TUNEL assay), then imaged at full thickness using confocal microscopy and quantified using custom CellProfiler pipelines. Early remyelination time points were marked by an increased density of total proliferating cells, including oligodendrocyte progenitor cells. Late remyelination time points featured increased TUNEL+ oligodendrocyte progenitor cells: however, most TUNEL+ cells within remyelinating lesions were Iba1+ microglia\/macrophages. These results indicate that repairing lesions are characterized by a high degree of glial cell death and suggest that monitoring cell death-related by-products might have clinical value in the setting of remyelination.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae386","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T15:24:34Z","timestamp":1734189874000},"source":"Crossref","is-referenced-by-count":3,"title":["Significant oligodendrocyte progenitor and microglial cell death is a feature of remyelination following toxin-induced experimental demyelination"],"prefix":"10.1093","volume":"7","author":[{"given":"Hallie","family":"Gaitsch","sequence":"first","affiliation":[{"name":"Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge , Cambridge CB2 0AW ,","place":["UK"]},{"name":"Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health , Bethesda, MD 20892 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