{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:43:38Z","timestamp":1790714618461,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":323,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017506","name":"Alzheimer\u2019s Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["TriBEKa-17-519007"],"award-info":[{"award-number":["TriBEKa-17-519007"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Brain Age Gap has been associated with dementia in old age. Less is known relating brain age gap to dementia risk-factors or cognitive performance in middle-age. Cognitively healthy, middle-aged subjects from PREVENT-Dementia had comprehensive neuropsychological, neuroimaging and genetic assessments. Brain Ages were predicted from T1-weighted 3T MRI scans. Cognition was assessed using the COGNITO computerized test battery. 552 middle-aged participants (median [interquartile range] age 52.8 [8.7] years, 60.0% female) had baseline data, of whom 95 had amyloid PET data. Brain age gap in middle-age was associated with hypertension (P = 0.007) and alcohol intake (P = 0.008) but not apolipoprotein E epsilon 4 allele (P = 0.14), amyloid centiloids (P = 0.39) or cognitive performance (P = 0.74). Brain age gap in middle-age is associated with modifiable dementia risk-factors, but not with genetic risk for Alzheimer's disease, amyloid deposition or cognitive performance. These results are important for understanding brain-age in middle-aged populations, which might be optimally targeted by future dementia-preventing therapies.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae392","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T13:05:36Z","timestamp":1732021536000},"source":"Crossref","is-referenced-by-count":23,"title":["Brain age gap, dementia risk factors and cognition in middle age"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1362-0538","authenticated-orcid":false,"given":"James D","family":"Stefaniak","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Cambridge School of Clinical Medicine , Cambridge CB2 0SP ,","place":["UK"]},{"name":"Cambridgeshire and Peterborough NHS Foundation Trust , Cambridge CB21 5EF 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