{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T13:33:34Z","timestamp":1772544814350,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":323,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marie Sk\u0142odowska-Curie","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ADG-101096455"],"award-info":[{"award-number":["ADG-101096455"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ADG-101053962"],"award-info":[{"award-number":["ADG-101053962"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ZEN24-1069572"],"award-info":[{"award-number":["ZEN24-1069572"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG-23-1061717"],"award-info":[{"award-number":["SG-23-1061717"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ZEN-21-848495"],"award-info":[{"award-number":["ZEN-21-848495"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG-23-1038904"],"award-info":[{"award-number":["SG-23-1038904"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015595","name":"GHR Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2022-00775"],"award-info":[{"award-number":["2022-00775"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2021-02219"],"award-info":[{"award-number":["2021-02219"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2023-00356"],"award-info":[{"award-number":["2023-00356"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2022-01018"],"award-info":[{"award-number":["2022-01018"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2019-02397"],"award-info":[{"award-number":["2019-02397"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2017-00915"],"award-info":[{"award-number":["2017-00915"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2022-00732"],"award-info":[{"award-number":["2022-00732"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERA PerMed","award":["ERAPERMED2021-184"],"award-info":[{"award-number":["ERAPERMED2021-184"]}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","award":["2022-0231"],"award-info":[{"award-number":["2022-0231"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Strategic Research Area MultiPark"},{"name":"Multidisciplinary Research in Parkinson\u2019s disease"},{"DOI":"10.13039\/501100003252","name":"Lund University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Alzheimer Foundation","award":["AF-980907"],"award-info":[{"award-number":["AF-980907"]}]},{"name":"Swedish Alzheimer Foundation","award":["AF-994229"],"award-info":[{"award-number":["AF-994229"]}]},{"name":"Swedish Alzheimer Foundation","award":["AF-930351"],"award-info":[{"award-number":["AF-930351"]}]},{"name":"Swedish Alzheimer Foundation","award":["AF-939721"],"award-info":[{"award-number":["AF-939721"]}]},{"name":"Swedish Alzheimer Foundation","award":["AF-968270"],"award-info":[{"award-number":["AF-968270"]}]},{"name":"Swedish Alzheimer Foundation","award":["AF-994551"],"award-info":[{"award-number":["AF-994551"]}]},{"DOI":"10.13039\/501100003792","name":"Swedish Brain Foundation","doi-asserted-by":"crossref","award":["FO2021-0293"],"award-info":[{"award-number":["FO2021-0293"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003792","name":"Swedish Brain Foundation","doi-asserted-by":"crossref","award":["FO2023-0163"],"award-info":[{"award-number":["FO2023-0163"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003792","name":"Swedish Brain Foundation","doi-asserted-by":"crossref","award":["FO2017-0243"],"award-info":[{"award-number":["FO2017-0243"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003792","name":"Swedish Brain Foundation","doi-asserted-by":"crossref","award":["ALZ2022-0006"],"award-info":[{"award-number":["ALZ2022-0006"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Parkinson foundation of Sweden","award":["1412\/22"],"award-info":[{"award-number":["1412\/22"]}]},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer's Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"name":"R\u00f6nstr\u00f6m Family Foundation","award":["FRS-0003"],"award-info":[{"award-number":["FRS-0003"]}]},{"DOI":"10.13039\/501100006129","name":"Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018911","name":"University Hospital Foundation","doi-asserted-by":"publisher","award":["2020-O000028"],"award-info":[{"award-number":["2020-O000028"]}],"id":[{"id":"10.13039\/501100018911","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Regionalt Forskningsst\u00f6d","award":["2022-1259"],"award-info":[{"award-number":["2022-1259"]}]},{"name":"Wallenberg AI, Autonomous Systems and Software Program"},{"name":"Data-Driven Life Science","award":["WASP\/DDLS22-066"],"award-info":[{"award-number":["WASP\/DDLS22-066"]}]},{"name":"EU Joint Programme Neurodegenerative Diseases","award":["2019-03401"],"award-info":[{"award-number":["2019-03401"]}]},{"name":"EU Joint Programme Neurodegenerative Diseases","award":["JPN2019-466-236"],"award-info":[{"award-number":["JPN2019-466-236"]}]},{"name":"Swedish federal government","award":["2022-Projekt0080"],"award-info":[{"award-number":["2022-Projekt0080"]}]},{"name":"Swedish federal government","award":["2022-Projekt0107"],"award-info":[{"award-number":["2022-Projekt0107"]}]},{"name":"Swedish federal government","award":["ALFGBG-715986"],"award-info":[{"award-number":["ALFGBG-715986"]}]},{"name":"Swedish federal government","award":["ALFGBG-965240"],"award-info":[{"award-number":["ALFGBG-965240"]}]},{"name":"La Fondation Recherche Alzheimer"},{"DOI":"10.13039\/501100014734","name":"FRA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007505","name":"Kirsten and Freddy Johansen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Disease-specific fluid biomarkers are in demand for parkinsonian syndromes (PS). Corticotropin-releasing hormone (CRH) was proposed as a biomarker for Lewy body disease. As such, this project aimed to confirm CRH as a potential biomarker for different PS. CRH and misfolded \u03b1-synuclein (\u03b1Syn) were measured in CSF. The primary cohort included Lewy body disease patients (i.e. Parkinson\u2019s disease or dementia with Lewy bodies, n = 77), atypical PS (n = 37) and non-parkinsonian neurodegenerative diseases (n = 164), as well as controls (n = 354). A replication cohort included Lewy body disease (n = 27), atypical PS (n = 58) and controls (n = 58). CRH was downregulated in \u03b1Syn positive Lewy body disease, \u03b1Syn positive controls and in all atypical PS compared with \u03b1Syn negative controls (P = 3.3e\u221205, P = 3.1e\u221210, P = 2.9e\u221203). CRH was also decreased in \u03b1Syn positive Lewy body disease compared with \u03b1Syn negative non-PS (P = 2e\u221203) and correlated with cognitive impairment and inflammation in \u03b1Syn positive Lewy body disease. We show that CRH is a promising biomarker for Lewy body disease and atypical PS and its association with inflammation and cognitive decline. Reductions in CRH in Lewy body disease and other PS suggest this decrease may relate to dopaminergic degeneration instead of \u03b1Syn pathology.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae414","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T13:40:53Z","timestamp":1732023653000},"source":"Crossref","is-referenced-by-count":6,"title":["Corticotropin-releasing hormone as a candidate biomarker for parkinsonian disorders"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1512-6699","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Fernandes Gomes","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg , 43180 M\u00f6lndal ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2166-4805","authenticated-orcid":false,"given":"Atul","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Clinical Memory Research Unit, Lund University , 20213 Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg , 43180 M\u00f6lndal ,","place":["Sweden"]},{"name":"Banner Alzheimer's Institute and University of Arizona , Phoenix, AZ 85006 ,","place":["USA"]},{"name":"Banner Sun Health Research Institute , Sun City, AZ 85351 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6585-9105","authenticated-orcid":false,"given":"Sara","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Clinical Memory Research Unit, Lund University , 20213 Malm\u00f6 ,","place":["Sweden"]},{"name":"Memory Clinic, Sk\u00e5ne University Hospital , 20502 Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Stomrud","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Clinical Memory Research Unit, Lund University , 20213 Malm\u00f6 ,","place":["Sweden"]},{"name":"Memory Clinic, Sk\u00e5ne University Hospital , 20502 Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7147-0112","authenticated-orcid":false,"given":"Ruben","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Clinical Memory Research Unit, Lund University , 20213 Malm\u00f6 ,","place":["Sweden"]},{"name":"Memory Clinic, Sk\u00e5ne University Hospital , 20502 Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg , 43180 M\u00f6lndal ,","place":["Sweden"]},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital , 43139 M\u00f6lndal ,","place":["Sweden"]},{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square , WC1N 3BG London ,","place":["UK"]},{"name":"UK Dementia Research Institute at UCL , W1T 7NF London ,","place":["UK"]},{"name":"Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay , HKG Hong Kong ,","place":["China"]},{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison , Madison, WI 53792 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg , 43180 M\u00f6lndal ,","place":["Sweden"]},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital , 43139 M\u00f6lndal ,","place":["Sweden"]},{"name":"Paris Brain Institute, ICM, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Sorbonne University , 75013 Paris ,","place":["France"]},{"name":"Division of Life Sciences and Medicine, Department of Neurology, Neurodegenerative Disorder Research Center, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC , 230026 Hefei ,","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8885-7724","authenticated-orcid":false,"given":"Niklas","family":"Mattsson-Carlgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Clinical Memory Research Unit, Lund University , 20213 Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Neurology, Sk\u00e5ne University Hospital , 22185 Lund ,","place":["Sweden"]},{"name":"Wallenberg Center for Molecular Medicine, Lund University , 22184 Lund ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-7286","authenticated-orcid":false,"given":"Oskar","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Clinical Memory Research Unit, Lund University , 20213 Malm\u00f6 ,","place":["Sweden"]},{"name":"Memory Clinic, Sk\u00e5ne University Hospital , 20502 Malm\u00f6 ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"issue":"S1","key":"2024122016270498600_fcae414-B1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.3233\/JPD-181474","article-title":"The emerging evidence of the Parkinson pandemic","volume":"8","author":"Dorsey","year":"2018","journal-title":"J Parkinsons Dis"},{"issue":"2","key":"2024122016270498600_fcae414-B2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S1474-4422(23)00405-2","article-title":"A biological definition of neuronal \u03b1-synuclein disease: Towards an integrated staging system for research","volume":"23","author":"Simuni","year":"2024","journal-title":"Lancet Neurol"},{"issue":"5 Movement Disorders","key":"2024122016270498600_fcae414-B3","first-page":"1189","article-title":"Parkinsonian syndromes","volume":"19","author":"Williams","year":"2013","journal-title":"Continuum (Minneap Minn)"},{"issue":"5","key":"2024122016270498600_fcae414-B4","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1212\/WNL.0000000000000641","article-title":"Low clinical diagnostic accuracy of early vs advanced Parkinson disease: Clinicopathologic study","volume":"83","author":"Adler","year":"2014","journal-title":"Neurology"},{"issue":"4","key":"2024122016270498600_fcae414-B5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/jnnp-2017-316844","article-title":"Accuracy of clinical diagnosis of dementia with Lewy bodies: A systematic review and meta-analysis","volume":"89","author":"Rizzo","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"2024122016270498600_fcae414-B6","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41591-021-01382-x","article-title":"Biomarkers for neurodegenerative diseases","volume":"27","author":"Hansson","year":"2021","journal-title":"Nat Med"},{"issue":"5","key":"2024122016270498600_fcae414-B7","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s43587-023-00403-3","article-title":"Blood biomarkers for Alzheimer\u2019s disease in clinical practice and trials","volume":"3","author":"Hansson","year":"2023","journal-title":"Nat Aging"},{"issue":"1","key":"2024122016270498600_fcae414-B8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00401-020-02160-8","article-title":"Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies","volume":"140","author":"Rossi","year":"2020","journal-title":"Acta Neuropathol"},{"issue":"7794","key":"2024122016270498600_fcae414-B9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41586-020-1984-7","article-title":"Discriminating \u03b1-synuclein strains in Parkinson's disease and multiple system atrophy","volume":"578","author":"Shahnawaz","year":"2020","journal-title":"Nature"},{"key":"2024122016270498600_fcae414-B10","doi-asserted-by":"crossref","first-page":"105807","DOI":"10.1016\/j.parkreldis.2023.105807","article-title":"\u03b1-Synuclein seed amplification assay as a diagnostic tool for parkinsonian disorders","volume":"117","author":"Fernandes Gomes","year":"2023","journal-title":"Parkinsonism Relat Disord"},{"issue":"10","key":"2024122016270498600_fcae414-B11","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1212\/WNL.0000000000003680","article-title":"Blood-based NfL: A biomarker for differential diagnosis of parkinsonian disorder","volume":"88","author":"Hansson","year":"2017","journal-title":"Neurology"},{"issue":"1","key":"2024122016270498600_fcae414-B12","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1038\/s41467-023-41122-y","article-title":"CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer\u00b4s disease","volume":"14","author":"Del Campo","year":"2023","journal-title":"Nat Commun"},{"issue":"20","key":"2024122016270498600_fcae414-B13","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","article-title":"The hypothalamic\u2013pituitary\u2013adrenal axis and immune-mediated inflammation","volume":"332","author":"Chrousos","year":"1995","journal-title":"N Engl J Med"},{"issue":"6054","key":"2024122016270498600_fcae414-B14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/319593a0","article-title":"Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease","volume":"319","author":"De Souza","year":"1986","journal-title":"Nature"},{"issue":"3","key":"2024122016270498600_fcae414-B15","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1212\/WNL.37.3.535","article-title":"Cerebrospinal fluid concentrations of corticotropin-releasing hormone (CRH) and corticotropin (ACTH) are reduced in patients with Alzheimer's disease","volume":"37","author":"May","year":"1987","journal-title":"Neurology"},{"issue":"4","key":"2024122016270498600_fcae414-B16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0006-3223(91)90221-7","article-title":"Neocortical concentrations of neuropeptides in senile dementia of the Alzheimer and Lewy body type: Comparison with Parkinson's disease and severity correlations","volume":"29","author":"Leake","year":"1991","journal-title":"Biol Psychiatry"},{"issue":"6","key":"2024122016270498600_fcae414-B17","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1212\/WNL.37.6.905","article-title":"Reductions in corticotropin releasing factor-like immunoreactivity in cerebral cortex in Alzheimer\u2019s disease, Parkinson\u2019s disease, and progressive supranuclear palsy","volume":"37","author":"Whitehouse","year":"1987","journal-title":"Neurology"},{"issue":"4680","key":"2024122016270498600_fcae414-B18","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1126\/science.6334362","article-title":"Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients","volume":"226","author":"Nemeroff","year":"1984","journal-title":"Science"},{"issue":"5","key":"2024122016270498600_fcae414-B19","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1176\/ajp.154.5.624","article-title":"Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder","volume":"154","author":"Bremner","year":"1997","journal-title":"Am J Psychiatry"},{"issue":"8","key":"2024122016270498600_fcae414-B20","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/s41591-023-02450-0","article-title":"Cognitive effects of Lewy body pathology in clinically unimpaired individuals","volume":"29","author":"Palmqvist","year":"2023","journal-title":"Nat Med"},{"issue":"4","key":"2024122016270498600_fcae414-B21","first-page":"919","article-title":"Progressive supranuclear palsy, corticobasal degeneration, and multiple system atrophy","volume":"25","author":"Greene","year":"2019","journal-title":"Continuum (Minneap Minn)"},{"issue":"4","key":"2024122016270498600_fcae414-B22","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/mds.21907","article-title":"Excessive dopamine neuron loss in progressive supranuclear palsy","volume":"23","author":"Murphy","year":"2008","journal-title":"Mov Disord"},{"issue":"1","key":"2024122016270498600_fcae414-B23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-022-00382-6","article-title":"Multiple system atrophy","volume":"8","author":"Poewe","year":"2022","journal-title":"Nat Rev Dis Primers"},{"issue":"7","key":"2024122016270498600_fcae414-B24","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0028-3908(92)90145-F","article-title":"D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats","volume":"31","author":"Borowsky","year":"1992","journal-title":"Neuropharmacology"},{"issue":"1","key":"2024122016270498600_fcae414-B25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0006-8993(96)00765-2","article-title":"Dopamine receptor-mediated regulation of corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus","volume":"738","author":"Eaton","year":"1996","journal-title":"Brain Res"},{"issue":"Suppl 1","key":"2024122016270498600_fcae414-B26","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1530\/eje.1.02353","article-title":"Novel insights in dopamine receptor physiology","volume":"156","author":"Pivonello","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"2024122016270498600_fcae414-B27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jchemneu.2013.05.003","article-title":"CRH: The link between hormonal-, metabolic- and behavioral responses to stress","volume":"54","author":"Kov\u00e1cs","year":"2013","journal-title":"J Chem Neuroanat"},{"issue":"6","key":"2024122016270498600_fcae414-B28","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","article-title":"Mechanisms underlying inflammation in neurodegeneration","volume":"140","author":"Glass","year":"2010","journal-title":"Cell"},{"key":"2024122016270498600_fcae414-B29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fncel.2012.00013","article-title":"Tuning synaptic transmission in the hippocampus by stress: The CRH system","volume":"6","author":"Chen","year":"2012","journal-title":"Front Cell Neurosci"},{"issue":"8","key":"2024122016270498600_fcae414-B30","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1093\/cercor\/bhx103","article-title":"The endogenous stress hormone CRH modulates excitatory transmission and network physiology in hippocampus","volume":"27","author":"Gunn","year":"2017","journal-title":"Cerebral Cortex"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcae414\/60749900\/fcae414.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/6\/6\/fcae414\/60832573\/fcae414.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/6\/6\/fcae414\/60832573\/fcae414.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T16:27:49Z","timestamp":1734712069000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcae414\/7904632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,10,30]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcae414","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024]]},"article-number":"fcae414"}}