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In this case-control study, we combined several predictors reflecting various possible mechanisms of spreading through structural and functional pathways to predict the topography of the four biomarkers in amyloid-positive patients while controlling for the effect of spatial distance along the cortex. For each biomarker, we quantified the relative contribution of each predictor to the variance explained by the model. We also compared the contribution between apolipoprotein E-\u025b4 carriers and non-carriers. We found that topological proximity to areas of maximal pathology through the functional connectome explained significant parts of variance for all biomarkers and that functional pathways totalized more than 30% of contributions for hypometabolism and amyloid load. By contrast, atrophy and tau load were mainly predicted by structural pathways, with major contributions from inter-regional diffusion. The \u025b4 allele modulated contributions to the four biomarkers in a way consistent with compromised brain connectomics in carriers. Our approach can be used to assess the contribution of concurrent mechanisms in other neurodegenerative diseases and the possible modifying impact of relevant factors on this contribution.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae459","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T15:47:35Z","timestamp":1736178455000},"source":"Crossref","is-referenced-by-count":4,"title":["Contributions of connectional pathways to shaping Alzheimer\u2019s disease pathologies"],"prefix":"10.1093","volume":"7","author":[{"given":"Salma","family":"Bougacha","sequence":"first","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND \u2018Physiopathology and Imaging of Neurological Disorders\u2019, Institut Blood and Brain @ Caen-Normandie, Cyceron , 14000 Caen 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