{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:13:40Z","timestamp":1791220420429,"version":"4.1.0"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["IZSEZ0_229208"],"award-info":[{"award-number":["IZSEZ0_229208"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The preclinical phase of Alzheimer\u2019s disease represents a crucial time window for therapeutic intervention but requires the identification of clinically relevant biomarkers that are sensitive to the effects of disease-modifying drugs. Amyloid peptide and tau proteins, the main histological hallmarks of Alzheimer\u2019s disease, have been widely used as biomarkers of anti-amyloid and anti-tau drugs. However, these biomarkers do not fully capture the multiple biological pathways of the brain. Indeed, robust amyloid-target engagement by anti-amyloid monoclonal antibodies has recently translated into modest cognitive and clinical benefits in Alzheimer\u2019s disease patients, albeit with potentially life-threatening side effects. Moreover, targeting the tau pathway has yet to result in any positive clinical outcomes. Findings from computational neuroscience have demonstrated that brain regions do not work in isolation but are interconnected within complex network structures. Brain connectivity studies suggest that misfolded proteins can spread through these connections, leading to the hypothesis that Alzheimer\u2019s disease is a pathology of network disconnectivity. Based on these assumptions, here we discuss how incorporating brain connectivity outcomes could better capture global brain functionality and, in conjunction with traditional Alzheimer\u2019s disease biomarkers, could facilitate the clinical development of new disease-modifying anti-Alzheimer\u2019s disease drugs.<\/jats:p>","DOI":"10.1093\/braincomms\/fcae460","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T14:18:54Z","timestamp":1734531534000},"source":"Crossref","is-referenced-by-count":24,"title":["Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?"],"prefix":"10.1093","volume":"7","author":[{"given":"Lorenzo","family":"Pini","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Universit\u00e0 degli Studi di Padova , 35121 Padova ,","place":["Italy"]},{"name":"Padova Neuroscience Center, Universit\u00e0 degli Studi di Padova , 35121 Padova ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6804-7858","authenticated-orcid":false,"given":"Simone","family":"Lista","sequence":"additional","affiliation":[{"name":"i+HeALTH Strategic Research Group, Department of Health Sciences, Miguel de Cervantes European University (UEMC) , Valladolid 47012 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1923-1653","authenticated-orcid":false,"given":"Alessandra","family":"Griffa","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Leenaards Memory Center, Lausanne University Hospital and University of Lausanne , Montpaisible 16, 1011 Lausanne ,","place":["Switzerland"]},{"name":"Medical Image Processing Laboratory, Neuro-X Institute, E\u0301cole Polytechnique Fe\u0301de\u0301rale De Lausanne (EPFL) , Campus Biotech Chemin des Mines 9, 1202 Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-6719","authenticated-orcid":false,"given":"Gilles","family":"Allali","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Leenaards Memory Center, Lausanne University Hospital and University of Lausanne , Montpaisible 16, 1011 Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0327-7262","authenticated-orcid":false,"given":"Bruno P","family":"Imbimbo","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Chiesi Farmaceutici , 43122 Parma ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"issue":"4","key":"2024123111010658800_fcae460-B1","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/s41591-024-02869-z","article-title":"Highly accurate blood test for Alzheimer\u2019s disease is similar or superior to clinical cerebrospinal fluid tests","volume":"30","author":"Barth\u00e9lemy","year":"2024","journal-title":"Nat Med"},{"issue":"5","key":"2024123111010658800_fcae460-B2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1212\/WNL.0000000000002923","article-title":"A\/T\/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers","volume":"87","author":"Jack","year":"2016","journal-title":"Neurology"},{"issue":"6","key":"2024123111010658800_fcae460-B3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in early symptomatic Alzheimer disease: The TRAILBLAZER-ALZ 2 randomized clinical trial","volume":"330","author":"Sims","year":"2023","journal-title":"JAMA"},{"issue":"1","key":"2024123111010658800_fcae460-B4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer\u2019s disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N Engl J Med"},{"issue":"12","key":"2024123111010658800_fcae460-B5","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1001\/jamaneurol.2022.3392","article-title":"Association of donanemab treatment with exploratory plasma biomarkers in early symptomatic Alzheimer disease: A secondary analysis of the TRAILBLAZER-ALZ randomized clinical trial","volume":"79","author":"Pontecorvo","year":"2022","journal-title":"JAMA Neurol"},{"issue":"8","key":"2024123111010658800_fcae460-B6","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1001\/jamaneurol.2022.1375","article-title":"Safety and efficacy of semorinemab in individuals with prodromal to mild Alzheimer disease: A randomized clinical trial","volume":"79","author":"Teng","year":"2022","journal-title":"JAMA Neurol"},{"issue":"12","key":"2024123111010658800_fcae460-B7","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1038\/s43587-023-00523-w","article-title":"TANGO: A placebo-controlled randomized phase 2 study of efficacy and safety of the anti-tau monoclonal antibody gosuranemab in early Alzheimer\u2019s disease","volume":"3","author":"Shulman","year":"2023","journal-title":"Nat Aging"},{"issue":"6","key":"2024123111010658800_fcae460-B8","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1093\/brain\/awad024","article-title":"Tilavonemab in early Alzheimer\u2019s disease: Results from a phase 2, randomized, double-blind study","volume":"146","author":"Florian","year":"2023","journal-title":"Brain"},{"issue":"6","key":"2024123111010658800_fcae460-B9","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/s41591-023-02326-3","article-title":"Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer\u2019s disease: A phase 1b, randomized, placebo-controlled trial","volume":"29","author":"Mummery","year":"2023","journal-title":"Nat Med"},{"issue":"5","key":"2024123111010658800_fcae460-B10","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00401-023-02631-8","article-title":"Co-pathology may impact outcomes of amyloid-targeting treatments: Clinicopathological results from two patients treated with aducanumab","volume":"146","author":"VandeVrede","year":"2023","journal-title":"Acta Neuropathol"},{"issue":"1","key":"2024123111010658800_fcae460-B11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41583-021-00533-w","article-title":"The probabilistic model of Alzheimer disease: The amyloid hypothesis revised","volume":"23","author":"Frisoni","year":"2022","journal-title":"Nat Rev Neurosci"},{"issue":"10","key":"2024123111010658800_fcae460-B12","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41583-023-00731-8","article-title":"Connectome-based modelling of neurodegenerative diseases: Towards precision medicine and mechanistic insight","volume":"24","author":"Vogel","year":"2023","journal-title":"Nat Rev Neurosci"},{"key":"2024123111010658800_fcae460-B13","doi-asserted-by":"crossref","first-page":"e49132","DOI":"10.7554\/eLife.49132","article-title":"Cortical tau deposition follows patterns of entorhinal functional connectivity in aging","volume":"8","author":"Adams","year":"2019","journal-title":"Elife"},{"issue":"1","key":"2024123111010658800_fcae460-B14","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/s41467-017-01150-x","article-title":"Earliest accumulation of \u03b2-amyloid occurs within the default-mode network and concurrently affects brain connectivity","volume":"8","author":"Palmqvist","year":"2017","journal-title":"Nat Commun"},{"issue":"4","key":"2024123111010658800_fcae460-B15","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/brain\/awz026","article-title":"Functional connectivity associated with tau levels in ageing, Alzheimer\u2019s, and small vessel disease","volume":"142","author":"Franzmeier","year":"2019","journal-title":"Brain"},{"issue":"7","key":"2024123111010658800_fcae460-B16","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jalz.2019.03.006","article-title":"Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer\u2019s disease","volume":"15","author":"Chiesa","year":"2019","journal-title":"Alzheimers Dement"},{"issue":"11","key":"2024123111010658800_fcae460-B17","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/nn.4135","article-title":"Functional connectome fingerprinting: Identifying individuals using patterns of brain connectivity","volume":"18","author":"Finn","year":"2015","journal-title":"Nat Neurosci"},{"issue":"1","key":"2024123111010658800_fcae460-B18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrneurol.2009.198","article-title":"Disease and the brain\u2019s dark energy","volume":"6","author":"Zhang","year":"2010","journal-title":"Nat Rev Neurol"},{"issue":"11","key":"2024123111010658800_fcae460-B19","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1523\/JNEUROSCI.1601-22.2023","article-title":"Spontaneous activity patterns in human attention networks code for hand movements","volume":"43","author":"Zhang","year":"2023","journal-title":"J Neurosci"},{"issue":"10","key":"2024123111010658800_fcae460-B20","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.tics.2011.08.003","article-title":"Large-scale brain networks and psychopathology: A unifying triple network model","volume":"15","author":"Menon","year":"2011","journal-title":"Trends Cogn Sci"},{"issue":"1","key":"2024123111010658800_fcae460-B21","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13195-024-01576-8","article-title":"Toward a more comprehensive understanding of network centrality disruption in amnestic mild cognitive impairment: A MEG multilayer approach","volume":"16","author":"Taguas","year":"2024","journal-title":"Alzheimers Res Ther"},{"key":"2024123111010658800_fcae460-B22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neurobiolaging.2017.06.009","article-title":"Cerebral PET glucose hypometabolism in subjects with mild cognitive impairment and higher EEG high-alpha\/low-alpha frequency power ratio","volume":"58","author":"Moretti","year":"2017","journal-title":"Neurobiol Aging"},{"key":"2024123111010658800_fcae460-B23","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s association workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"10","key":"2024123111010658800_fcae460-B24","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tins.2013.06.007","article-title":"Molecular nexopathies: A new paradigm of neurodegenerative disease","volume":"36","author":"Warren","year":"2013","journal-title":"Trends Neurosci"},{"issue":"34","key":"2024123111010658800_fcae460-B25","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1523\/JNEUROSCI.2177-05.2005","article-title":"Molecular, structural, and functional characterization of Alzheimer\u2019s disease: Evidence for a relationship between default activity, amyloid, and memory","volume":"25","author":"Buckner","year":"2005","journal-title":"J Neurosci"},{"issue":"1","key":"2024123111010658800_fcae460-B26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain\u2019s default network: Anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"2024123111010658800_fcae460-B27","doi-asserted-by":"crossref","first-page":"e26689","DOI":"10.1002\/hbm.26689","article-title":"Characterization of tau propagation pattern and cascading hypometabolism from functional connectivity in Alzheimer\u2019s disease","volume":"45","author":"Wang","year":"2024","journal-title":"Hum Brain Mapp"},{"issue":"4","key":"2024123111010658800_fcae460-B28","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.neuron.2011.11.033","article-title":"Propagation of tau pathology in a model of early Alzheimer\u2019s disease","volume":"73","author":"de Calignon","year":"2012","journal-title":"Neuron"},{"key":"2024123111010658800_fcae460-B29","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41580-024-00753-9","article-title":"Cellular and pathological functions of tau","volume":"25","author":"Parra Bravo","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7465","key":"2024123111010658800_fcae460-B30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature12481","article-title":"Self-propagation of pathogenic protein aggregates in neurodegenerative diseases","volume":"501","author":"Jucker","year":"2013","journal-title":"Nature"},{"issue":"3","key":"2024123111010658800_fcae460-B31","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s11682-016-9556-z","article-title":"Lower functional connectivity of default mode network in cognitively normal young adults with mutation of APP, presenilins and APOE \u03b54","volume":"11","author":"Su","year":"2017","journal-title":"Brain Imaging Behav"},{"issue":"8","key":"2024123111010658800_fcae460-B32","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1001\/jamaneurol.2015.1099","article-title":"Brain imaging and blood biomarker abnormalities in children with autosomal dominant Alzheimer disease: A cross-sectional study","volume":"72","author":"Quiroz","year":"2015","journal-title":"JAMA Neurol"},{"issue":"4","key":"2024123111010658800_fcae460-B33","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/jmri.28727","article-title":"Neurite orientation dispersion and density imaging in multiple sclerosis: A systematic review","volume":"58","author":"Seyedmirzaei","year":"2023","journal-title":"J Magn Reson Imaging"},{"issue":"4","key":"2024123111010658800_fcae460-B34","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.neuron.2023.11.014","article-title":"Amyloid induced hyperexcitability in default mode network drives medial temporal hyperactivity and early tau accumulation","volume":"112","author":"Giorgio","year":"2024","journal-title":"Neuron"},{"issue":"16","key":"2024123111010658800_fcae460-B35","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1523\/JNEUROSCI.3263-16.2017","article-title":"Phases of hyperconnectivity and hypoconnectivity in the default mode and salience networks track with amyloid and tau in clinically normal individuals","volume":"37","author":"Schultz","year":"2017","journal-title":"J Neurosci"},{"issue":"15","key":"2024123111010658800_fcae460-B36","doi-asserted-by":"crossref","first-page":"e2113641119","DOI":"10.1073\/pnas.2113641119","article-title":"Amyloid-\u03b2 and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer\u2019s disease","volume":"119","author":"Guzm\u00e1n-V\u00e9lez","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024123111010658800_fcae460-B37","doi-asserted-by":"crossref","first-page":"101751","DOI":"10.1016\/j.nicl.2019.101751","article-title":"Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers","volume":"22","author":"Lee","year":"2019","journal-title":"Neuroimage Clin"},{"issue":"5","key":"2024123111010658800_fcae460-B38","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1093\/brain\/awq075","article-title":"Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer\u2019s disease","volume":"133","author":"Zhou","year":"2010","journal-title":"Brain"},{"issue":"4","key":"2024123111010658800_fcae460-B39","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/hbm.22248","article-title":"Neuropsychiatric symptoms in Alzheimer\u2019s disease are related to functional connectivity alterations in the salience network","volume":"35","author":"Balthazar","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"2024123111010658800_fcae460-B40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neurobiolaging.2021.11.005","article-title":"Brain network modulation in Alzheimer\u2019s and frontotemporal dementia with transcranial electrical stimulation","volume":"111","author":"Pini","year":"2022","journal-title":"Neurobiol Aging"},{"issue":"1","key":"2024123111010658800_fcae460-B41","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/s42003-024-06829-8","article-title":"Fingerprints of brain disease: Connectome identifiability in Alzheimer\u2019s disease","volume":"7","author":"Stampacchia","year":"2024","journal-title":"Commun Biol"},{"issue":"8","key":"2024123111010658800_fcae460-B42","doi-asserted-by":"crossref","first-page":"e29420","DOI":"10.1016\/j.heliyon.2024.e29420","article-title":"Behavioral and dysexecutive variant of Alzheimer\u2019s disease: Insights from structural and molecular imaging studies","volume":"10","author":"Nabizadeh","year":"2024","journal-title":"Heliyon"},{"issue":"1","key":"2024123111010658800_fcae460-B43","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1001\/jamaneurol.2021.4417","article-title":"Research criteria for the behavioral variant of Alzheimer disease: A systematic review and meta-analysis","volume":"79","author":"Ossenkoppele","year":"2022","journal-title":"JAMA Neurol"},{"issue":"13","key":"2024123111010658800_fcae460-B44","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1212\/WNL.0000000000003165","article-title":"Aphasic variant of Alzheimer disease: Clinical, anatomic, and genetic features","volume":"87","author":"Rogalski","year":"2016","journal-title":"Neurology"},{"issue":"11","key":"2024123111010658800_fcae460-B45","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"issue":"3","key":"2024123111010658800_fcae460-B46","doi-asserted-by":"crossref","first-page":"e12474","DOI":"10.1002\/dad2.12474","article-title":"Consensus recommendations for clinical assessment tools for the diagnosis of posterior cortical atrophy syndrome from the atypical AD PIA of ISTAART","volume":"15","author":"Pelak","year":"2023","journal-title":"Alzheimers Dement (Amst)"},{"key":"2024123111010658800_fcae460-B47","doi-asserted-by":"crossref","first-page":"101482","DOI":"10.1016\/j.arr.2021.101482","article-title":"Breakdown of specific functional brain networks in clinical variants of Alzheimer\u2019s disease","volume":"72","author":"Pini","year":"2021","journal-title":"Ageing Res Rev"},{"issue":"24","key":"2024123111010658800_fcae460-B48","doi-asserted-by":"crossref","first-page":"11471","DOI":"10.1093\/cercor\/bhad380","article-title":"Prediction of misfolded proteins spreading in Alzheimer\u2019s disease using machine learning and spreading models","volume":"33","author":"Gherardini","year":"2023","journal-title":"Cereb Cortex"},{"issue":"36","key":"2024123111010658800_fcae460-B49","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1523\/JNEUROSCI.2574-18.2019","article-title":"Neuroinflammation and functional connectivity in Alzheimer\u2019s disease: Interactive influences on cognitive performance","volume":"39","author":"Passamonti","year":"2019","journal-title":"J Neurosci"},{"issue":"3","key":"2024123111010658800_fcae460-B50","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/s41380-022-01878-z","article-title":"Neuroinflammation is independently associated with brain network dysfunction in Alzheimer\u2019s disease","volume":"28","author":"Leng","year":"2023","journal-title":"Mol Psychiatry"},{"issue":"1","key":"2024123111010658800_fcae460-B51","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41467-019-14159-1","article-title":"Functional brain architecture is associated with the rate of tau accumulation in Alzheimer\u2019s disease","volume":"11","author":"Franzmeier","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"2024123111010658800_fcae460-B52","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/hbm.24790","article-title":"Aberrant brain network connectivity in presymptomatic and manifest Huntington\u2019s disease: A systematic review","volume":"41","author":"Pini","year":"2020","journal-title":"Hum Brain Mapp"},{"issue":"4","key":"2024123111010658800_fcae460-B53","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3233\/JPD-191592","article-title":"Functional connectivity signatures of Parkinson\u2019s disease","volume":"9","author":"Tessitore","year":"2019","journal-title":"J Parkinsons Dis"},{"key":"2024123111010658800_fcae460-B54","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cortex.2017.12.017","article-title":"On the low dimensionality of behavioral deficits and alterations of brain network connectivity after focal injury","volume":"107","author":"Corbetta","year":"2018","journal-title":"Cortex"},{"issue":"30","key":"2024123111010658800_fcae460-B55","doi-asserted-by":"crossref","first-page":"E4367","DOI":"10.1073\/pnas.1521083113","article-title":"Disruptions of network connectivity predict impairment in multiple behavioral domains after stroke","volume":"113","author":"Siegel","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024123111010658800_fcae460-B56","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1001\/jamaneurol.2023.3284","article-title":"White matter tract density index prediction model of overall survival in glioblastoma","volume":"80","author":"Salvalaggio","year":"2023","journal-title":"JAMA Neurol"},{"issue":"7","key":"2024123111010658800_fcae460-B57","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S1474-4422(24)00160-1","article-title":"Glioblastoma and brain connectivity: The need for a paradigm shift","volume":"23","author":"Salvalaggio","year":"2024","journal-title":"Lancet Neurol"},{"key":"2024123111010658800_fcae460-B58","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fnagi.2019.00213","article-title":"Resting state networks in the TgF344-AD rat model of Alzheimer\u2019s disease are altered from early stages","volume":"11","author":"Tudela","year":"2019","journal-title":"Front Aging Neurosci"},{"key":"2024123111010658800_fcae460-B59","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.nbd.2018.11.010","article-title":"Early functional connectivity deficits and progressive microstructural alterations in the TgF344-AD rat model of Alzheimer\u2019s disease: A longitudinal MRI study","volume":"124","author":"Anckaerts","year":"2019","journal-title":"Neurobiol Dis"},{"key":"2024123111010658800_fcae460-B60","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fnagi.2019.00039","article-title":"Early stage alterations in white matter and decreased functional interhemispheric hippocampal connectivity in the 3xTg mouse model of Alzheimer\u2019s disease","volume":"11","author":"Manno","year":"2019","journal-title":"Front Aging Neurosci"},{"issue":"6453","key":"2024123111010658800_fcae460-B61","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.aay0198","article-title":"A vicious cycle of \u03b2 amyloid-dependent neuronal hyperactivation","volume":"365","author":"Zott","year":"2019","journal-title":"Science"},{"issue":"12","key":"2024123111010658800_fcae460-B62","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1038\/nn.4163","article-title":"Decreased amyloid-\u03b2 and increased neuronal hyperactivity by immunotherapy in Alzheimer\u2019s models","volume":"18","author":"Busche","year":"2015","journal-title":"Nat Neurosci"},{"issue":"32","key":"2024123111010658800_fcae460-B63","doi-asserted-by":"crossref","first-page":"8631","DOI":"10.1073\/pnas.1708106114","article-title":"BACE inhibition-dependent repair of Alzheimer\u2019s pathophysiology","volume":"114","author":"Keskin","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"2024123111010658800_fcae460-B64","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41582-018-0116-6","article-title":"A critical appraisal of amyloid-\u03b2-targeting therapies for Alzheimer disease","volume":"15","author":"Panza","year":"2019","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"2024123111010658800_fcae460-B65","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/agm2.12017","article-title":"Functional MRI technologies in the study of medication treatment effect on Alzheimer\u2019s disease","volume":"1","author":"Guo","year":"2018","journal-title":"Aging Med (Milton)"},{"issue":"3","key":"2024123111010658800_fcae460-B66","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2165\/11586440-000000000-00000","article-title":"Effect of memantine on resting state default mode network activity in Alzheimer's disease","volume":"28","author":"Lorenzi","year":"2011","journal-title":"Drugs Aging"},{"issue":"5","key":"2024123111010658800_fcae460-B67","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1089\/brain.2022.0026","article-title":"Cholinesterase inhibitors response might be related to right hippocampal functional connectivity in mild Alzheimer\u2019s disease","volume":"13","author":"Rizzi","year":"2023","journal-title":"Brain Connect"},{"issue":"1","key":"2024123111010658800_fcae460-B68","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/WNF.0000000000000427","article-title":"Effects of rivastigmine on brain functional networks in patients with Alzheimer disease based on the graph theory","volume":"44","author":"Zhang","year":"2021","journal-title":"Clin Neuropharmacol"},{"issue":"3","key":"2024123111010658800_fcae460-B69","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1159\/000450546","article-title":"Donepezil enhances frontal functional connectivity in Alzheimer\u2019s disease: A pilot study","volume":"6","author":"Griffanti","year":"2016","journal-title":"Dement Geriatr Cogn Dis Extra"},{"issue":"11","key":"2024123111010658800_fcae460-B70","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1097\/WNR.0000000000001659","article-title":"Effects of donepezil on the amplitude of low-frequency fluctuations in the brain of patients with Alzheimer\u2019s disease: Evidence from resting-state functional magnetic resonance imaging","volume":"32","author":"Yang","year":"2021","journal-title":"Neuroreport"},{"issue":"2","key":"2024123111010658800_fcae460-B71","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/WNF.0000000000000324","article-title":"Donepezil\u2019s effects on brain functions of patients with Alzheimer disease: A regional homogeneity study based on resting-state functional magnetic resonance imaging","volume":"42","author":"Cheng","year":"2019","journal-title":"Clin Neuropharmacol"},{"issue":"2","key":"2024123111010658800_fcae460-B72","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10072-023-07114-y","article-title":"The effects of different acetylcholinesterase inhibitors on EEG patterns in patients with Alzheimer\u2019s disease: A systematic review","volume":"45","author":"Arjmandi-Rad","year":"2024","journal-title":"Neurol Sci"},{"key":"2024123111010658800_fcae460-B73","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1038\/s41593-024-01763-8","article-title":"Synergistic association of A\u03b2 and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults","volume":"27","author":"Gallego-Rudolf","year":"2024","journal-title":"Nat Neurosci"},{"issue":"5","key":"2024123111010658800_fcae460-B74","doi-asserted-by":"crossref","first-page":"e249220","DOI":"10.1001\/jamanetworkopen.2024.9220","article-title":"Effectiveness of personalized hippocampal network\u2013targeted stimulation in Alzheimer disease: A randomized clinical trial","volume":"7","author":"Jung","year":"2024","journal-title":"JAMA Netw Open"},{"issue":"12","key":"2024123111010658800_fcae460-B75","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/jamaneurol.2023.4038","article-title":"Apoe4 and connectivity-mediated spreading of tau pathology at lower amyloid levels","volume":"80","author":"Steward","year":"2023","journal-title":"JAMA Neurol"},{"issue":"6","key":"2024123111010658800_fcae460-B76","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/WCO.0000000000000387","article-title":"Brain networks stimulation in dementia: Insights from functional imaging","volume":"29","author":"Pievani","year":"2016","journal-title":"Curr Opin Neurol"},{"key":"2024123111010658800_fcae460-B77","doi-asserted-by":"crossref","first-page":"118973","DOI":"10.1016\/j.neuroimage.2022.118973","article-title":"Brain simulation as a cloud service: The virtual brain on EBRAINS","volume":"251","author":"Schirner","year":"2022","journal-title":"NeuroImage"},{"key":"2024123111010658800_fcae460-B78","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.nicl.2018.04.017","article-title":"Differentiation of Alzheimer\u2019s disease based on local and global parameters in personalized Virtual Brain models","volume":"19","author":"Zimmermann","year":"2018","journal-title":"Neuroimage Clin"},{"issue":"1","key":"2024123111010658800_fcae460-B79","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1038\/s41598-021-83739-3","article-title":"Brain network analysis reveals that amyloidopathy affects comorbid cognitive dysfunction in older adults with depression","volume":"11","author":"Lee","year":"2021","journal-title":"Sci Rep"},{"key":"2024123111010658800_fcae460-B80","doi-asserted-by":"crossref","first-page":"117832","DOI":"10.1016\/j.neuroimage.2021.117832","article-title":"Vascular risk factors are associated with a decline in resting-state functional connectivity in cognitively unimpaired individuals at risk for Alzheimer\u2019s disease: Vascular risk factors and functional connectivity changes","volume":"231","author":"K\u00f6be","year":"2021","journal-title":"Neuroimage"},{"key":"2024123111010658800_fcae460-B81","doi-asserted-by":"crossref","first-page":"102409","DOI":"10.1016\/j.nicl.2020.102409","article-title":"Longitudinal functional connectivity changes related to dopaminergic decline in Parkinson\u2019s disease","volume":"28","author":"Li","year":"2020","journal-title":"Neuroimage Clin"},{"issue":"2","key":"2024123111010658800_fcae460-B82","doi-asserted-by":"crossref","first-page":"e12385","DOI":"10.1002\/trc2.12385","article-title":"Alzheimer\u2019s disease drug development pipeline: 2023","volume":"9","author":"Cummings","year":"2023","journal-title":"Alzheimers Dement (N Y)"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcae460\/61229232\/fcae460.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/7\/1\/fcae460\/61229232\/fcae460.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/7\/1\/fcae460\/61229232\/fcae460.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T06:01:39Z","timestamp":1735624899000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcae460\/7927930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12,24]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcae460","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2024,12,18]]},"article-number":"fcae460"}}