{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:47:41Z","timestamp":1793231261683,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Blood-based biomarkers have been revolutionizing the detection, diagnosis and screening of Alzheimer\u2019s disease. Specifically, phosphorylated-tau variants (p-tau181, p-tau217 and p-tau231) are promising biomarkers for identifying Alzheimer\u2019s disease pathology. Antibody-based assays such as single molecule arrays immunoassays are powerful tools to investigate pathological changes indicated by blood-based biomarkers and have been studied extensively in the Alzheimer\u2019s disease research field. A novel proteomic technology\u2014NUcleic acid Linked Immuno-Sandwich Assay (NULISA)\u2014was developed to improve the sensitivity of traditional proximity ligation assays and offer a comprehensive outlook for 120 protein biomarkers in neurodegenerative diseases. Due to the relative novelty of the NULISA technology in quantifying Alzheimer\u2019s disease biomarkers, validation through comparisons with more established methods is required. The main objective of the current study was to determine the capability of p-tau variants quantified using NULISA for identifying abnormal amyloid-\u03b2 and tau pathology. We assessed 397 participants [mean (standard deviation) age, 64.8 (15.7) years; 244 females (61.5%) and 153 males (38.5%)] from the Translational Biomarkers in Aging and Dementia (TRIAD) cohort where participants had plasma measurements of p-tau181, p-tau217 and p-tau231 from NULISA and single molecule arrays immunoassays. Participants also underwent neuroimaging assessments, including structural MRI, amyloid-PET and tau-PET. Our findings suggest an excellent agreement between plasma p-tau variants quantified using NULISA and single molecule arrays immunoassays. Plasma p-tau217 measured with NULISA shows excellent discriminative accuracy for abnormal amyloid-PET (area under the receiver operating characteristic curve = 0.918, 95% confidence interval = 0.883 to 0.953, P &amp;lt; 0.0001) and tau-PET (area under the receiver operating characteristic curve = 0.939; 95% confidence interval = 0.909 to 0.969, P &amp;lt; 0.0001). It also presents the capability for differentiating tau-PET staging. Validation of the NULISA-measured plasma biomarkers adds to the current analytical methods for Alzheimer\u2019s disease diagnosis, screening and staging and could potentially expedite the development of a blood-based biomarker panel.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf004","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T15:19:41Z","timestamp":1736176781000},"source":"Crossref","is-referenced-by-count":18,"title":["Identify biological Alzheimer\u2019s disease using a novel nucleic acid\u2013linked protein immunoassay"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9130-5461","authenticated-orcid":false,"given":"Yi-Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]},{"name":"Montreal Neurological Institute , Montreal, QC , H3A 2B4","place":["Canada"]},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University , Montreal, QC , H3A 0G4","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg , 431 39 M\u00f6lndal ,","place":["Sweden"]},{"name":"Centre for Age-Related Medicine, Stavanger University Hospital , 4011 Stavanger ,","place":["Norway"]},{"name":"Maurice Wohl Clinical Neuroscience Institute , King\u2019s College London, London SE5 9RX ,","place":["UK"]},{"name":"NIHR Maudsley Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation , London SE5 8AZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7826-4781","authenticated-orcid":false,"given":"Joseph","family":"Therriault","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]},{"name":"Montreal Neurological Institute , Montreal, QC , H3A 2B4","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-1741","authenticated-orcid":false,"given":"Andr\u00e9a L","family":"Benedet","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg , 431 39 M\u00f6lndal ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur C","family":"Macedo","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]},{"name":"Montreal Neurological Institute , Montreal, QC , H3A 2B4","place":["Canada"]},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University , Montreal, QC , H3A 0G4","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Pola","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg , 431 39 M\u00f6lndal ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Aumont","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]},{"name":"Montreal Neurological Institute , Montreal, QC , H3A 2B4","place":["Canada"]},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University , Montreal, QC , H3A 0G4","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guglielmo","family":"Di Molfetta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg , 431 39 M\u00f6lndal ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6810-5920","authenticated-orcid":false,"given":"Jaime","family":"Fernandez-Arias","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]},{"name":"Montreal Neurological Institute , Montreal, QC , H3A 2B4","place":["Canada"]},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University , Montreal, QC , H3A 0G4","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kubra","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg , 431 39 M\u00f6lndal ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrine","family":"Rahmouni","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]},{"name":"Montreal Neurological Institute , Montreal, QC , H3A 2B4","place":["Canada"]},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University , Montreal, QC , H3A 0G4","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn Johannes G","family":"Servaes","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Isaacson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Cornell Medicine and New York-Presbyterian , New York, NY 10065 ,","place":["USA"]},{"name":"Department of Neurology, Florida Atlantic University, Charles E. Schmidt College of Medicine , Boca Raton, FL 33431 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tevy","family":"Chan","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]},{"name":"Montreal Neurological Institute , Montreal, QC , H3A 2B4","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Ali","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]},{"name":"Montreal Neurological Institute , Montreal, QC , H3A 2B4","place":["Canada"]},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University , Montreal, QC , H3A 0G4","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Tissot","sequence":"additional","affiliation":[{"name":"Lawrence Berkeley National Laboratory , Berkeley, CA 94720 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulantha","family":"Mathotaarachchi","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-4825","authenticated-orcid":false,"given":"Firoza Z","family":"Lussier","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry, University of Pittsburgh School of Medicine , Pittsburgh, PA 15213 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharick A","family":"Pascoal","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry, University of Pittsburgh School of Medicine , Pittsburgh, PA 15213 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University , Montreal, QC , H3A 0G4","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg , 431 39 M\u00f6lndal ,","place":["Sweden"]},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital , 413 45 M\u00f6lndal ,","place":["Sweden"]},{"name":"Paris Brain Institute, ICM, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Sorbonne University , 75013 Paris ,","place":["France"]},{"name":"Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC , Hefei 101127, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg , 431 39 M\u00f6lndal ,","place":["Sweden"]},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital , 413 45 M\u00f6lndal ,","place":["Sweden"]},{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology , London WC1N 3BG ,","place":["UK"]},{"name":"UK Dementia Research Institute at UCL , London W1CE 6BT ,","place":["UK"]},{"name":"Hong Kong Center for Neurodegenerative Diseases , Hong Kong ,","place":["China"]},{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison , Madison, WI 53792 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-1376","authenticated-orcid":false,"given":"Pedro","family":"Rosa-Neto","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging , Montreal, QC , H4H 1R2","place":["Canada"]},{"name":"Montreal Neurological Institute , Montreal, QC , H3A 2B4","place":["Canada"]},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University , Montreal, QC , H3A 0G4","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"2025012105411694700_fcaf004-B1","doi-asserted-by":"crossref","first-page":"15056","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer\u2019s disease","volume":"1","author":"Masters","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"2025012105411694700_fcaf004-B2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/WCO.0000000000001198","article-title":"Advanced brain imaging for the diagnosis of Alzheimer disease","volume":"36","author":"Wang","year":"2023","journal-title":"Curr Opin Neurol"},{"issue":"10284","key":"2025012105411694700_fcaf004-B3","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer\u2019s disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"3","key":"2025012105411694700_fcaf004-B4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1474-4422(06)70355-6","article-title":"Association between CSF biomarkers and incipient Alzheimer\u2019s disease in patients with mild cognitive impairment: A follow-up study","volume":"5","author":"Hansson","year":"2006","journal-title":"Lancet Neurol"},{"issue":"6","key":"2025012105411694700_fcaf004-B5","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S1474-4422(14)70090-0","article-title":"Advancing research diagnostic criteria for Alzheimer\u2019s disease: The IWG-2 criteria","volume":"13","author":"Dubois","year":"2014","journal-title":"Lancet Neurol"},{"issue":"8","key":"2025012105411694700_fcaf004-B6","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S1474-4422(22)00168-5","article-title":"Tau biomarkers in Alzheimer\u2019s disease: Towards implementation in clinical practice and trials","volume":"21","author":"Ossenkoppele","year":"2022","journal-title":"Lancet Neurol"},{"issue":"8","key":"2025012105411694700_fcaf004-B7","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s Association Workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"4","key":"2025012105411694700_fcaf004-B8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: Toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"issue":"5","key":"2025012105411694700_fcaf004-B9","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s43587-023-00403-3","article-title":"Blood biomarkers for Alzheimer\u2019s disease in clinical practice and trials","volume":"3","author":"Hansson","year":"2023","journal-title":"Nat Aging"},{"issue":"1","key":"2025012105411694700_fcaf004-B10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer\u2019s disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N Engl J Med"},{"issue":"11","key":"2025012105411694700_fcaf004-B11","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41582-018-0079-7","article-title":"Blood-based biomarkers for Alzheimer disease: Mapping the road to the clinic","volume":"14","author":"Hampel","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"2025012105411694700_fcaf004-B12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13024-023-00689-2","article-title":"Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer\u2019s disease pathology","volume":"19","author":"Therriault","year":"2024","journal-title":"Mol Neurodegener"},{"issue":"3","key":"2025012105411694700_fcaf004-B13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jamaneurol.2023.5319","article-title":"Diagnostic accuracy of a plasma phosphorylated tau 217 immunoassay for Alzheimer disease pathology","volume":"81","author":"Ashton","year":"2024","journal-title":"JAMA Neurol"},{"issue":"1","key":"2025012105411694700_fcaf004-B14","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1038\/s41467-023-42834-x","article-title":"NULISA: A proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing","volume":"14","author":"Feng","year":"2023","journal-title":"Nat Commun"},{"issue":"11","key":"2025012105411694700_fcaf004-B15","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1038\/s41591-021-01568-3","article-title":"Publisher correction: Microglial activation and tau propagate jointly across Braak stages","volume":"27","author":"Pascoal","year":"2021","journal-title":"Nat Med"},{"issue":"6","key":"2025012105411694700_fcaf004-B16","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s43587-022-00204-0","article-title":"Biomarker modeling of Alzheimer\u2019s disease using PET-based Braak staging","volume":"2","author":"Therriault","year":"2022","journal-title":"Nat Aging"},{"issue":"2","key":"2025012105411694700_fcaf004-B17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2967\/jnumed.120.245209","article-title":"Determining amyloid-\u03b2 positivity using 18F-AZD4694 PET imaging","volume":"62","author":"Therriault","year":"2021","journal-title":"J Nucl Med"},{"issue":"7","key":"2025012105411694700_fcaf004-B18","doi-asserted-by":"crossref","first-page":"e975","DOI":"10.1212\/WNL.0000000000011416","article-title":"Frequency of biologically defined Alzheimer disease in relation to age, sex, APOE \u03b54, and cognitive impairment","volume":"96","author":"Therriault","year":"2021","journal-title":"Neurology"},{"issue":"5","key":"2025012105411694700_fcaf004-B19","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S1474-4422(20)30071-5","article-title":"Blood phosphorylated tau 181 as a biomarker for Alzheimer\u2019s disease: A diagnostic performance and prediction modelling study using data from four prospective cohorts","volume":"19","author":"Karikari","year":"2020","journal-title":"Lancet Neurol"},{"issue":"5","key":"2025012105411694700_fcaf004-B20","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00401-021-02275-6","article-title":"Plasma p-tau231: A new biomarker for incipient Alzheimer\u2019s disease pathology","volume":"141","author":"Ashton","year":"2021","journal-title":"Acta Neuropathol."},{"issue":"1","key":"2025012105411694700_fcaf004-B21","doi-asserted-by":"crossref","first-page":"e12204","DOI":"10.1002\/dad2.12204","article-title":"Development and validation of a high-sensitivity assay for measuring p217+ tau in plasma","volume":"13","author":"Triana-Baltzer","year":"2021","journal-title":"Alzheimers Dement (Amst)"},{"issue":"1","key":"2025012105411694700_fcaf004-B22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13195-022-01005-8","article-title":"Diagnostic and prognostic performance to detect Alzheimer\u2019s disease and clinical progression of a novel assay for plasma p-tau217","volume":"14","author":"Groot","year":"2022","journal-title":"Alzheimers Res Ther"},{"key":"2025012105411694700_fcaf004-B23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fninf.2016.00020","article-title":"VoxelStats: A MATLAB package for multi-modal voxel-wise brain image analysis","volume":"10","author":"Mathotaarachchi","year":"2016","journal-title":"Front Neuroinformatics"},{"issue":"7","key":"2025012105411694700_fcaf004-B24","doi-asserted-by":"crossref","first-page":"e68910","DOI":"10.1371\/journal.pone.0068910","article-title":"BrainNet Viewer: A network visualization tool for human brain connectomics","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"2025012105411694700_fcaf004-B25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41380-020-00923-z","article-title":"Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer\u2019s Disease Neuroimaging Initiative","volume":"26","author":"Karikari","year":"2021","journal-title":"Mol Psychiatry"},{"issue":"11","key":"2025012105411694700_fcaf004-B26","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1002\/alz.13026","article-title":"Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer\u2019s disease","volume":"19","author":"Therriault","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"11","key":"2025012105411694700_fcaf004-B27","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1093\/brain\/awaa286","article-title":"Longitudinal plasma p-tau217 is increased in early stages of Alzheimer\u2019s disease","volume":"143","author":"Mattsson-Carlgren","year":"2020","journal-title":"Brain"},{"issue":"2","key":"2025012105411694700_fcaf004-B28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1001\/jamaneurol.2020.4201","article-title":"Associations of plasma phospho-tau217 levels with tau positron emission tomography in early Alzheimer disease","volume":"78","author":"Janelidze","year":"2021","journal-title":"JAMA Neurol"},{"issue":"8","key":"2025012105411694700_fcaf004-B29","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1056\/NEJM199802193380804","article-title":"Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer\u2019s disease. Alzheimer\u2019s Disease Centers Consortium on apolipoprotein E and Alzheimer\u2019s disease","volume":"338","author":"Mayeux","year":"1998","journal-title":"N Engl J Med"},{"issue":"1","key":"2025012105411694700_fcaf004-B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000334607","article-title":"Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4\/4) among patients diagnosed with Alzheimer\u2019s disease: A systematic review and meta-analysis","volume":"38","author":"Ward","year":"2012","journal-title":"Neuroepidemiology"},{"issue":"10","key":"2025012105411694700_fcaf004-B31","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1038\/s41380-022-01675-8","article-title":"Sex differences in plasma p-tau181 associations with Alzheimer\u2019s disease biomarkers, cognitive decline, and clinical progression","volume":"27","author":"Tsiknia","year":"2022","journal-title":"Mol Psychiatry"},{"issue":"4","key":"2025012105411694700_fcaf004-B32","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/brain\/awad397","article-title":"Sex-specific modulation of amyloid-\u03b2 on tau phosphorylation underlies faster tangle accumulation in females","volume":"147","author":"Wang","year":"2024","journal-title":"Brain"},{"issue":"3","key":"2025012105411694700_fcaf004-B33","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1001\/jamaneurol.2018.3692","article-title":"Correlation of in vivo [18f]flortaucipir with postmortem Alzheimer disease tau pathology","volume":"76","author":"Smith","year":"2019","journal-title":"JAMA Neurol"},{"issue":"11","key":"2025012105411694700_fcaf004-B34","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1093\/brain\/awaa276","article-title":"18F-flortaucipir PET to autopsy comparisons in Alzheimer\u2019s disease and other neurodegenerative diseases","volume":"143","author":"Soleimani-Meigooni","year":"2020","journal-title":"Brain"},{"issue":"7","key":"2025012105411694700_fcaf004-B35","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jalz.2019.03.016","article-title":"Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease","volume":"15","author":"Lowe","year":"2019","journal-title":"Alzheimers Dement"},{"issue":"9","key":"2025012105411694700_fcaf004-B36","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s43587-023-00471-5","article-title":"A two-step workflow based on plasma p-tau217 to screen for amyloid \u03b2 positivity with further confirmatory testing only in uncertain cases","volume":"3","author":"Brum","year":"2023","journal-title":"Nat Aging"},{"issue":"2","key":"2025012105411694700_fcaf004-B37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s43587-023-00565-0","article-title":"Plasma proteomic profiles predict future dementia in healthy adults","volume":"4","author":"Guo","year":"2024","journal-title":"Nat Aging"},{"issue":"3","key":"2025012105411694700_fcaf004-B38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1001\/jamaneurol.2018.4249","article-title":"Assessment of racial disparities in biomarkers for Alzheimer disease","volume":"76","author":"Morris","year":"2019","journal-title":"JAMA Neurol"},{"key":"2025012105411694700_fcaf004-B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/alz.14413","article-title":"Benchmarking of a multi-biomarker low-volume panel for Alzheimer\u2019s disease and related dementia research","author":"Ibanez","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"1","key":"2025012105411694700_fcaf004-B40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2217\/bmm.09.84","article-title":"Blood-based biomarkers of Alzheimer\u2019s disease: Challenging but feasible","volume":"4","author":"Thambisetty","year":"2010","journal-title":"Biomark Med"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcaf004\/61371112\/fcaf004.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcaf004\/61371112\/fcaf004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcaf004\/61371112\/fcaf004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:41:44Z","timestamp":1737420104000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcaf004\/7945154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,24]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12,24]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcaf004","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2024,12,24]]},"article-number":"fcaf004"}}