{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:46:49Z","timestamp":1791586009216,"version":"4.3.4"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371429"],"award-info":[{"award-number":["82371429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071200"],"award-info":[{"award-number":["82071200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272039"],"award-info":[{"award-number":["82272039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82021002"],"award-info":[{"award-number":["82021002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173599"],"award-info":[{"award-number":["82173599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Ministry of Science and Technology","award":["SQ2021AAA010157"],"award-info":[{"award-number":["SQ2021AAA010157"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Early-onset Alzheimer\u2019s disease constitutes \u223c5\u201310% of Alzheimer\u2019s disease. Its clinical characteristics and biomarker profiles are not well documented. To compare the characteristics covering clinical, neuropsychological and biomarker profiles between patients with early- and late-onset Alzheimer\u2019s disease, we enrolled 203 patients (late-onset Alzheimer\u2019s disease = 99; early-onset Alzheimer\u2019s disease = 104) from a Chinese hospital-based cohort, the Shanghai Memory Study. A full panel of plasma biomarkers under the amyloid\/tau\/neurodegeneration framework including plasma amyloid beta 40, amyloid beta 42, total-tau, neurofilament light chain and phosphorylated tau 181 were assayed using ultra-sensitive Simoa technology. Seventy-five patients underwent an amyloid molecular positron emission tomography scan whereas 43 received comprehensive amyloid, Tau deposition and hypometabolism analysis. Clinical features, plasma and imaging biomarkers were compared cross-sectionally. Compared to those with late-onset Alzheimer\u2019s disease, patients with early-onset Alzheimer\u2019s disease presented more severe impairment in language function, lower frequency of APOE \u025b4 and lower levels of plasma neurofilament light chain (all P &amp;lt; 0.05). The plasma phosphorylated tau 181 concentration and phosphorylated tau 181\/amyloid beta 42 ratios were higher in early-onset Alzheimer\u2019s disease than in late-onset Alzheimer\u2019s disease (all P &amp;lt; 0.05). More severe Tau deposition as indicated by 18F-florzolotau binding in the precuneus, posterior cingulate cortex and angular gyrus was observed in the early-onset Alzheimer\u2019s disease group. Plasma phosphorylated tau 181 was associated with earlier age at onset and domain-specific cognitive impairment, especially in patients with early-onset Alzheimer\u2019s disease. We concluded that patients with early-onset Alzheimer\u2019s disease differed from late-onset Alzheimer\u2019s disease in cognitive performance and biomarker profile. A higher burden of pathological tau was observed in early-onset Alzheimer\u2019s disease and was associated with earlier age at onset and more profound cognitive impairment.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf015","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T02:38:47Z","timestamp":1736995127000},"source":"Crossref","is-referenced-by-count":5,"title":["Clinical characteristics and biomarker profile in early- and late-onset Alzheimer\u2019s disease: the Shanghai Memory Study"],"prefix":"10.1093","volume":"7","author":[{"given":"Jie","family":"Wu","sequence":"first","affiliation":[{"name":"Institute and Department of Neurology, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"National Center for Neurological Disorders, Huashan Hospital, Fudan University , Shanghai 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Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University , Shanghai 200235 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Guan","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University , Shanghai 200235 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuantao","family":"Zuo","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University , Shanghai 200235 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