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However, the involvement of myelin content and microstructural alterations in subjective cognitive decline has not previously been investigated. This study included three groups of participants recruited from the Compostela Aging Study project: 53 cognitively unimpaired adults, 16 individuals with subjective cognitive decline and hippocampal atrophy and 70 with subjective cognitive decline and no hippocampal atrophy. Group differences were analysed across five MRI biomarkers derived from multi-component T2 relaxometry, each sensitive to variations in cerebral composition and microstructural tissue integrity. Although no significant differences in myelin content were observed between groups, the subjective cognitive decline with hippocampal atrophy group exhibited a larger free-water fraction, and reduced fraction and relaxation times of the intra\/extracellular water compartment in frontal, parietal and medial temporal lobe brain regions and white matter tracts as compared with the other groups. Moreover, both subjective cognitive decline groups displayed lower total water content as compared with the control group and the subjective cognitive decline with hippocampal atrophy group showed lower total water content as compared with the subjective cognitive decline without hippocampal atrophy group. These changes are likely related to microstructural tissue differences related to neuroinflammation, axonal degeneration, iron accumulation or other physiologic variations, calling for further examinations.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf017","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T02:35:42Z","timestamp":1737081342000},"source":"Crossref","is-referenced-by-count":7,"title":["Brain microstructure alterations in subjective cognitive decline: a multi-component T2 relaxometry study"],"prefix":"10.1093","volume":"7","author":[{"given":"Miguel \u00c1ngel","family":"Rivas-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Children\u2019s Hospital of Los Angeles , Los Angeles, CA 90027 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Bouhrara","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical 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,","place":["Spain"]},{"name":"Applied Cognitive Neuroscience and Psychogerontology Research Group (Neucoga-Aging), Instituto de Psicolox\u00eda, USC (IPsiUS) , Santiago de Compostela, 15782 ,","place":["Spain"]},{"name":"Cognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS) , Santiago de Compostela, 15706 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Zurr\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela (USC) , Santiago de Compostela 15782 ,","place":["Spain"]},{"name":"Applied Cognitive Neuroscience and Psychogerontology Research Group (Neucoga-Aging), Instituto de Psicolox\u00eda, USC (IPsiUS) , Santiago de Compostela, 15782 ,","place":["Spain"]},{"name":"Cognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS) , Santiago de Compostela, 15706 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela (USC) , Santiago de Compostela 15782 ,","place":["Spain"]},{"name":"Applied Cognitive Neuroscience and Psychogerontology Research Group (Neucoga-Aging), Instituto de Psicolox\u00eda, USC (IPsiUS) , Santiago de Compostela, 15782 ,","place":["Spain"]},{"name":"Cognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS) , Santiago de Compostela, 15706 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5242-3203","authenticated-orcid":false,"given":"Santiago","family":"Galdo-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela (USC) , 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