{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:52:09Z","timestamp":1793742729340,"version":"4.6.1"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["grant number: 210839\/225270"],"award-info":[{"award-number":["grant number: 210839\/225270"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Davson\u2019s equation relates the state of stable intracranial pressure (ICP) to the production rate of CSF (IF) and resistance to CSF outflow (ROUT). Both parameters are assumed to be independent of ICP, but results are conflicting. The objective is to define the relationship between ICP, IF and ROUT using a systematic literature review. Medline and Embase were searched from inception up to 12 February 2024. Experimental studies exploring the association between ICP, IF, and ROUT were included. Individual measurements of ICP, IF and\/or ROUT were extracted from tables or graphs, alongside descriptive parameters (population, ICP measurement site, disease, and computational method). Linear regression and mixed effects models were applied. From 1304 references, 25 articles were included in our meta-analysis. IF is approximately constant across all pathologies independent of the ICP level, population, disease, ICP measurement site and the measurement\/estimation method. Conversely, ICP was positively correlated with ROUT. The intercorrelation, however, differed by population, disease, ICP measurement site and estimation method. Additionally, IF derived from Davson\u2019s Equation compared with the measured IF were similar for patients with hydrocephalus but differed for patients with acute brain injury. Davson\u2019s Equation describes the various components of cerebrospinal fluid dynamics. The results underline important caveats for its use in patients with acute brain injury wherein the estimated values differ from the measured ones. Overall, additional metrics describing the cerebrovascular system or the underlying disease have to be taken into account for more accurate estimations.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf044","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T14:37:06Z","timestamp":1738247826000},"source":"Crossref","is-referenced-by-count":3,"title":["CSF production rate, resistance to reabsorption, and intracranial pressure: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8283-305X","authenticated-orcid":false,"given":"Ihsane","family":"Olakorede","sequence":"first","affiliation":[{"name":"Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge , Cambridge CB2 0QQ 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