{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:28:56Z","timestamp":1791919736993,"version":"4.3.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Moyamoya disease (MMD) may lead to perfusion deficits, stroke and brain atrophy in the long term. Our aim was to analyze whole-brain volumetry (WBV) of a large cohort of MMD patients compared to healthy controls.<\/jats:p>\n                  <jats:p>3D T1w MRI sequences of adult MMD patients treated at our center between 2016-2022 without prior revascularization were analyzed for WBV (AssemblyNet) and compared age-controlled to healthy controls (HC). A total of 133 different regions of interest (ROI) were examined retrospectively for each patient separately by localization, structure and tissue type. All segmentations were subjected to automated and manual quality control (QC).<\/jats:p>\n                  <jats:p>After QC, 149 hemispheres from 80 MMD patients were compared to 258 hemispheres from 129 HC. A significant brain volume loss was observed in MMD patients with increasing age, with the greatest reduction seen in bilaterally affected patients with Suzuki grade &amp;gt;3. As direct signs of brain atrophy, significant differences were seen across all ROIs, emphasized in cortical gray matter (GM) with a reduction of 4.4% (95%CI 2.7%\u20136.1%; p&amp;lt;.001) in patients aged 30-45y and 3.4% (95%CI 2.1% 4.7%; p&amp;lt;.001) aged 46-60y. As indirect sign for atrophy, external CSF spaces increased by up to 26.4% (95%CI 17.0%\u201335.9%; p&amp;lt;.001) for 30-45y and 28.4% (95%CI 17.1%\u201339.7%; p&amp;lt;.001) for 46-60y compared to HC. Infratentorial, significant volume loss was observed for patients aged 46-60y with 11.6% for cerebellar white matter (WM) (95%CI 3.7%\u201319.5%; p=.0025) and with 8.5% (95%CI 3.5%\u201313.5%; p=.0006) for the brainstem, likely due to secondary neurodegeneration. MMD patients &amp;gt;45y without ischemia also had significantly less GM and WM volume, with accordingly enlarged CSF spaces.<\/jats:p>\n                  <jats:p>MMD may lead to significant differences in brain volume of local and global ROI as a sign of brain atrophy, even in the absence of infarctions. These findings might be useful for the understanding of the disease burden and in decision making for timely revascularization.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf100","type":"journal-article","created":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T15:15:57Z","timestamp":1740928557000},"source":"Crossref","is-referenced-by-count":4,"title":["Whole-brain volumetric analysis in adult moyamoya patients reveals significant atrophy compared to healthy controls"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7728-2091","authenticated-orcid":false,"given":"Patrick","family":"Haas","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Moyamoya Center, University of T\u00fcbingen , Hoppe-Seyler-Stra\u00dfe 3, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Debolski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Moyamoya Center, University of T\u00fcbingen , Hoppe-Seyler-Stra\u00dfe 3, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of T\u00fcbingen , Hoppe-Seyler-Stra\u00dfe 3, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Zerweck","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of T\u00fcbingen , Hoppe-Seyler-Stra\u00dfe 3, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Ernemann","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of T\u00fcbingen , Hoppe-Seyler-Stra\u00dfe 3, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Tatagiba","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Moyamoya Center, University of T\u00fcbingen , Hoppe-Seyler-Stra\u00dfe 3, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till-Karsten","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of T\u00fcbingen , Hoppe-Seyler-Stra\u00dfe 3, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Moyamoya Center, University of T\u00fcbingen , Hoppe-Seyler-Stra\u00dfe 3, 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Moyamoya Center, University Children\u2019s Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, and University of Zurich , 8032 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Roder","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Moyamoya Center, University of T\u00fcbingen , Hoppe-Seyler-Stra\u00dfe 3, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,3]]},"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcaf100\/62244339\/fcaf100.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcaf100\/62244339\/fcaf100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T19:17:27Z","timestamp":1741115847000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article\/doi\/10.1093\/braincomms\/fcaf100\/8051153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcaf100","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,3]]},"article-number":"fcaf100"}}