{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:29:34Z","timestamp":1792056574273,"version":"4.4.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":147,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EU Joint Programme Neurodegenerative Disease Research","award":["ANR-20-JPW2-0004-04"],"award-info":[{"award-number":["ANR-20-JPW2-0004-04"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["AC20\/00121"],"award-info":[{"award-number":["AC20\/00121"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson\u2019s","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson\u2019s Research","doi-asserted-by":"publisher","award":["ASAP-020505"],"award-info":[{"award-number":["ASAP-020505"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Investissements d'Avenir","award":["IAIHU-06"],"award-info":[{"award-number":["IAIHU-06"]}]},{"name":"Paris Institute of Neurosciences"},{"name":"Fondation d\u2019Entreprise EDF"},{"DOI":"10.13039\/100005614","name":"Biogen Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JPND Control-PD","award":["ANR-21-JPW2-0005-05"],"award-info":[{"award-number":["ANR-21-JPW2-0005-05"]}]},{"name":"Fondation Th\u00e9r\u00e8se and Ren\u00e9 Planiol"},{"DOI":"10.13039\/501100011068","name":"Fondation Saint Michel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011068","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Energipole"},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de M\u00e9decine Esth\u00e9tique"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neuromelanin-sensitive MRI has been proposed as a biomarker of Parkinson\u2019s disease pathology. However, the biological and physical origins of this contrast are debated. A recent rodent model of controlled neuromelanin accumulation in the substantia nigra has been developed and recapitulates several features of Parkinson\u2019s disease. In this work, we first combined neuromelanin-sensitive-MRI and histology to study neuromelanin accumulation and neurodegeneration in a humanized rat model of Parkinson\u2019s disease. Neuromelanin-sensitive-MRI signal changes were biphasic with an initial increase due to the accumulation of neuromelanin in dopaminergic neurons, followed signal decrease due to neurodegeneration. In healthy subjects and patients with isolated rapid eye movement sleep behaviour disorder, neuromelanin-sensitive-MRI signal increased initially and then decreased similarly as in rodents after reaching a similar maximum signal intensity in both groups. In early Parkinson\u2019s disease and converted isolated rapid eye movement sleep behaviour disorder patients, neuromelanin-sensitive-MRI signal drop was greater than in healthy individuals. Results in animals and humans show that neuromelanin-sensitive-MRI is a marker of the intracellular neuromelanin accumulation and then of neuronal degeneration and originates mainly from T1 reduction effect of neuromelanin.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf204","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T07:34:48Z","timestamp":1748331288000},"source":"Crossref","is-referenced-by-count":15,"title":["Longitudinal neuromelanin changes in prodromal and early Parkinson\u2019s disease in humans and rat model"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6066-2909","authenticated-orcid":false,"given":"Jean-Baptiste","family":"P\u00e9rot","sequence":"first","affiliation":[{"name":"Paris Brain Institute \u2013 ICM, MOVIT Team, Sorbonne Universit\u00e9, Inserm U1127, CNRS 7225, H\u00f4pital Piti\u00e9-Salp\u00eatriere , Paris 75013 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ICM, Centre de NeuroImagerie de Recherche \u2013 CENIR, Sorbonne Universit\u00e9, Inserm U1127, CNRS 7225, H\u00f4pital Piti\u00e9-Salp\u00eatriere , Paris 75013 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois-Xavier","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Paris Brain Institute \u2013 ICM, Data Analysis Core, Sorbonne Universit\u00e9, Inserm U1127, CNRS 7225, H\u00f4pital Piti\u00e9-Salp\u00eatriere , Paris 75013 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2240-2516","authenticated-orcid":false,"given":"Isabelle","family":"Arnulf","sequence":"additional","affiliation":[{"name":"Paris Brain Institute \u2013 ICM, MOVIT Team, Sorbonne Universit\u00e9, Inserm U1127, CNRS 7225, H\u00f4pital Piti\u00e9-Salp\u00eatriere , Paris 75013 ,","place":["France"]},{"name":"Sleep Disorders Unit, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, AP-HP , Paris 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