{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:32:15Z","timestamp":1790353935064,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":169,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["UL1TR001873"],"award-info":[{"award-number":["UL1TR001873"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cerebrovascular dysfunction is associated with risk and progression of Alzheimer\u2019s disease, but the extent to which it promotes Alzheimer\u2019s pathophysiology is unclear. Understanding the relationship between cerebrovascular dysfunction and Alzheimer\u2019s disease markers in midlife is critical to inform our understanding of the earliest manifestations of the disease and prevention strategies. We examined the association of cerebral blood flow with two biomarkers of tau pathophysiology, plasma phosphorylated tau 181 (p-tau181) concentrations and tau PET MK6240 standard uptake value ratio. This was a cross-sectional study of participants in the Offspring Study in upper Manhattan. Analyses included arterial spin labelling MRI, plasma p-tau181 concentration and 18F-MK-6240 tau PET data in the entorhinal cortex. Four hundred and fifty-nine participants (54.8 \u00b1 10.8 years old, 63.3% women) had available MRI and plasma p-tau181 data, and 98 (60.4 \u00b1 5.8 years old, 61.2% women) had additional tau PET data. Lower cerebral blood flow was associated with both higher plasma p-tau181 concentration and entorhinal cortex tau standard uptake value ratio. Higher plasma p-tau181 levels were associated with small clusters of lower regional cerebral blood flow, primarily in regions that correspond to sites of early Alzheimer\u2019s disease pathology. Higher tau PET levels were associated with lower cerebral blood flow throughout the brain. These findings suggest that there is relationship between cerebral blood flow and indicators of tau pathophysiology in middle age that is likely bidirectional.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf249","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T18:05:12Z","timestamp":1751047512000},"source":"Crossref","is-referenced-by-count":5,"title":["Cerebral blood flow is associated with plasma and PET biomarkers of tau pathology in middle age"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9622-1219","authenticated-orcid":false,"given":"Alexander L","family":"Houck","sequence":"first","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad J","family":"Alshikho","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-3547","authenticated-orcid":false,"given":"Patrick J","family":"Lao","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D","family":"Pyne","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira C","family":"Turney","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology & Population Sciences, National Institute on Aging, National Institutes of Health , Baltimore, MD 21224 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Mazen","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Benavides","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Hale","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Herman","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joncarlos","family":"Berroa","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie C","family":"Edwards","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-8078","authenticated-orcid":false,"given":"Jose","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Simoes","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9481-7497","authenticated-orcid":false,"given":"Jennifer J","family":"Manly","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Gertrude H. 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