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Fox Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012479","name":"Weston Brain Institute","doi-asserted-by":"publisher","award":["MJFF-007878"],"award-info":[{"award-number":["MJFF-007878"]}],"id":[{"id":"10.13039\/100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT- 173540"],"award-info":[{"award-number":["PJT- 173540"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Krembil-Rossy Chair programme"},{"DOI":"10.13039\/501100005155","name":"Azrieli Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs Programme","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001805","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001805","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ontario Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The [18F]SynVest-1 radiotracer targets the synaptic vesicle glycoprotein 2A (SV2A) and is a proxy of presynaptic density. Parkinson\u2019s disease is associated with synaptic dysfunction. Here we investigated synaptic density via the [18F]SynVest-1 radiotracer in people with PD compared with healthy controls, with reference to how it compares to the previous SV2A radiotracer, [11C]UCB-J. Ten Parkinson\u2019s patients and 12 healthy subjects underwent a [18F]SynVest-1 PET scan. We compared non-displaceable binding potential via voxel-wise and volume of interest analysis to investigate group differences. Volume-of-interest-analyses reported lower non-displaceable binding potential in key a priori regions associated with Parkinson\u2019s disease, namely the substantia nigra and caudate nucleus (P &amp;lt; 0.05). Follow-up exploratory volume-of-interest-analyses reported widespread reduction in non-displaceable binding potential within all brain lobes, cerebellum, hippocampus, thalamus and insula; however, these findings did not survive correction for multiple comparisons (P &amp;lt; 0.004). In addition, voxel-wise analyses with family-wise error correction, highlighted significantly lower non-displaceable binding potential in the PD cohort within the putamen and cerebellum. We did not observe any relationships between clinical metrics and non-displaceable binding potential. The results are in line with differences observed using the [11C]UCB-J radiotracer. The [18F]SynVest-1 radiotracer confirmed lower synaptic density in the Parkinson\u2019s disease cohort and adds to the growing evidence of synaptic dysfunction in Parkinson\u2019s disease pathology.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf258","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T09:08:27Z","timestamp":1752656907000},"source":"Crossref","is-referenced-by-count":7,"title":["[18F]SynVest-1 PET imaging in people with Parkinson\u2019s disease"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6382-3977","authenticated-orcid":false,"given":"Sarah L","family":"Martin","sequence":"first","affiliation":[{"name":"Temerty Faculty of Medicine, University of Toronto , 27 King's College Circle, Toronto, Ontario M5S 1A1 ,","place":["Canada"]},{"name":"Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH) , Toronto M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychology, Faculty of Health and Education, Translational and Computational Neuroscience Unit, Manchester Metropolitan University , Manchester M15 6GX ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Uribe","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH) , Toronto M5T 1R8 ,","place":["Canada"]},{"name":"Krembil Brain Institute, University Health Network, University of Toronto , Toronto, Ontario M5T 1S8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly L","family":"Desmond","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH) , Toronto M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , Toronto M5T 1R8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Narciso","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH) , Toronto M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , Toronto M5T 1R8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayla","family":"Dolman","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH) , Toronto M5T 1R8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo","family":"Torres-Carmona","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH) , Toronto M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , Toronto M5T 1R8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Boileau","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH) , Toronto M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , Toronto M5T 1R8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Graff-Guerrero","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH) , Toronto M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , Toronto M5T 1R8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2087-5125","authenticated-orcid":false,"given":"Neil","family":"Vasdev","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH) , Toronto M5T 1R8 ,","place":["Canada"]},{"name":"Department of Psychiatry, University of Toronto , Toronto M5T 1R8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio P","family":"Strafella","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine, University of Toronto , 27 King's College Circle, Toronto, Ontario M5S 1A1 ,","place":["Canada"]},{"name":"Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH) , Toronto M5T 1R8 ,","place":["Canada"]},{"name":"Krembil Brain Institute, University Health Network, University of Toronto , Toronto, Ontario M5T 1S8 ,","place":["Canada"]},{"name":"Neurology Division, Department of Medicine, Morton and Gloria Shulman Movement Disorder Unit and Edmond J. Safra Program in Parkinson Disease, Toronto Western Hospital, University Health Network, University of Toronto , Toronto M5T 2S6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"issue":"5321","key":"2025100802515372600_fcaf258-B1","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the \u03b1-synuclein gene identified in families with Parkinson\u2019s disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"issue":"12","key":"2025100802515372600_fcaf258-B2","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.1074\/jbc.275.12.8812","article-title":"Membrane association and protein conformation of alpha-synuclein in intact neurons. 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