{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:51:27Z","timestamp":1790362287264,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":196,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001722","name":"Royal Netherlands Academy of Arts and Sciences","doi-asserted-by":"publisher","award":["09-PD-14"],"award-info":[{"award-number":["09-PD-14"]}],"id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Netherlands Foundation for Scientific Research","award":["017.106.310"],"award-info":[{"award-number":["017.106.310"]}]},{"DOI":"10.13039\/501100005981","name":"Direktorat Jenderal Pendidikan Tinggi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005981","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["#833247"],"award-info":[{"award-number":["#833247"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001832","name":"Radboud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001832","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009509","name":"Ministry of Research, Technology and Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009509","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Using Tryptophan Metabolism and Response to Corticosteroids to Define New Therapeutic Targets for Tuberculosis Meningitis: Integration of Large Scale Clinical, Metabolomic, and Genomic Data","award":["R01AI145781"],"award-info":[{"award-number":["R01AI145781"]}]},{"name":"INtegrative omics and aspirin response to define ThERapeutiC targEts for Pediatric Tbm","award":["R01AI165721"],"award-info":[{"award-number":["R01AI165721"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study examines the role of host inflammation in the high mortality of tuberculous meningitis (TBM) and identifies potential biomarkers associated with improved survival. We conducted a case-control study involving 131 patients in a discovery cohort, 81 TBM patients in a validation cohort, and 43 non-infected controls from a referral hospital in Indonesia. We measured 94 inflammation-related proteins in cerebrospinal fluid (CSF) and performed genome-wide quantitative trait loci (QTL) mapping. Sixty-seven proteins were found to be differentially expressed between TBM patients and controls, with 64 proteins elevated in patients. Five proteins, including vascular endothelial growth factor (VEGF) and matrix metalloproteinase-10 (MMP-10), were identified as predictors of 180-day mortality in TBM patients. The validation cohort confirmed that MMP-10, but not VEGF, was predictive of mortality. Genome-wide QTL mapping identified two genome-wide significant and four suggestive genetic loci associated with CSF MMP-10, which also predicted survival in an additional cohort of 218 patients. High CSF concentrations of MMP-10, along with specific genetic loci, may be associated with survival in TBM patients, suggesting a potential role for MMP-10 in disease pathogenesis and warranting further investigation into its utility in host-directed therapies.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf273","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T19:01:32Z","timestamp":1752692492000},"source":"Crossref","is-referenced-by-count":9,"title":["Inflammatory markers in the cerebrospinal fluid linked to mortality in tuberculous meningitis"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-4171","authenticated-orcid":false,"given":"Sofiati","family":"Dian","sequence":"first","affiliation":[{"name":"Research Centre for Care and Control of Infectious Diseases (RC3ID), Faculty of Medicine, Universitas Padjadjaran , 40161 Bandung ,","place":["Indonesia"]},{"name":"Department of Neurology, Faculty of Medicine, 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