{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T14:05:07Z","timestamp":1770473107649,"version":"3.49.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":231,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"French National Institute for Health and Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Agency for Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Normandy Regional Council"},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French Universitary Institute"},{"name":"Programme Hospitalier de Recherche Clinique","award":["PHRCN 2011-A01493-38"],"award-info":[{"award-number":["PHRCN 2011-A01493-38"]}]},{"name":"Programme Hospitalier de Recherche Clinique","award":["PHRCN 2012 12-006-0347"],"award-info":[{"award-number":["PHRCN 2012 12-006-0347"]}]},{"DOI":"10.13039\/501100007494","name":"Fondation Plan Alzheimer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007494","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association France Alzheimer et maladies apparent\u00e9es","award":["AAP 2013"],"award-info":[{"award-number":["AAP 2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Distinguishing aetiologies of neurocognitive disorder (NCD) between alcohol-induced pathologies (OH) and Alzheimer\u2019s disease poses a major clinical challenge while dual diagnosis may be common. We aimed to define commonalities and specificities of neurocognitive alterations in OH or Alzheimer's Disease, considering the NCD severity (mild\/major). In this retrospective cross-sectional study, we included 203 participants: 50 Mild-NCD-OH patients, 18 Major-NCD-OH patients, 30 Mild-NCD-AD patients, 24 Major-NCD-AD patients, as well as 81 healthy controls. Patients were compared on a neuropsychological and multimodal neuroimaging assessment (grey\/white matter density and glucose metabolism). Analyses explored commonalities and specificities of each patient group within each NCD severity. All patient groups had episodic memory impairments, medial temporal lobe damage and hypometabolism in thalami and posteromedial cortex. NCD-AD patients had more severe cognitive deficits than NCD-OH patients, and the reverse pattern was observed for brain damage. NCD-OH patients notably showed more severe thalamic and cingulate alterations. NCD-OH patients also presented cerebellar damage not observed in NCD-AD. Volume deficits in the medial temporal lobe and memory deficits were more severe in Mild-NCD-AD than Mild-NCD-OH, but similar in Major-NCD-AD and Major-NCD-OH. Common alterations are observed in NCD-OH and NCD-AD, mainly within the memory circuit. Only cerebellar damage appears to be specific to NCD-OH. The specificity of NCD-AD deficits relies on their severity since they are also present to a lesser extent in NCD-OH, reinforcing how the neurocognitive phenotypes overlap. These results reaffirm the importance of questioning alcohol consumption in NCD-AD patients and considering an Alzheimer's Disease diagnosis in NCD-OH patients.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf289","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T11:19:52Z","timestamp":1755515992000},"source":"Crossref","is-referenced-by-count":3,"title":["Cognitive and cerebral phenotypes of neurocognitive disorders due to alcohol or Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0940-0812","authenticated-orcid":false,"given":"C\u00e9lia","family":"Soussi","sequence":"first","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND \u2018Physiopathology and Imaging of Neurological Disorders\u2019, NeuroPresage Team, Cyceron , Caen 14000 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\u2018Physiopathology and Imaging of Neurological Disorders\u2019, NeuroPresage Team, Cyceron , Caen 14000 ,","place":["France"]},{"name":"Normandie Univ, UNIROUEN, CRFDP (EA 7475) , Rouen 76000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Coulbault","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND \u2018Physiopathology and Imaging of Neurological Disorders\u2019, NeuroPresage Team, Cyceron , Caen 14000 ,","place":["France"]},{"name":"Service de Biochimie, Centre Hospitalier Universitaire de Caen , Caen 14000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Boudehent","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND \u2018Physiopathology and Imaging of Neurological Disorders\u2019, NeuroPresage Team, Cyceron , Caen 14000 ,","place":["France"]},{"name":"Service d'Addictologie, Centre Hospitalier Universitaire de Caen , Caen 14000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"de la Sayette","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND \u2018Physiopathology and Imaging of Neurological Disorders\u2019, NeuroPresage Team, Cyceron , Caen 14000 ,","place":["France"]},{"name":"Service de Neurologie, Centre Hospitalier Universitaire de Caen , Caen 14000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00ebl","family":"Ch\u00e9telat","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND \u2018Physiopathology and Imaging of Neurological Disorders\u2019, NeuroPresage Team, Cyceron , Caen 14000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Lise","family":"Pitel","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, 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