{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:27:06Z","timestamp":1787502426952,"version":"build-2736575974"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":236,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201557"],"award-info":[{"award-number":["82201557"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disorder characterized by muscle weakness, atrophy and myotonia, with multi-system involvement. Recent studies have highlighted the pathological heterogeneity within the CNS of DM1 patients, particularly significant changes in spinal transcriptome expression and alternative splicing. In this study, we conducted a comprehensive transcriptome analysis of the spinal cord in the muscle-specific DM1 mouse model and their wild-type controls across different life stages: young, adult and old age. Our results revealed an age-dependent increase in differential gene expression between DM1 and wild-type mice with a predominance of downregulated genes. Notably, five genes (Adgre1, Ccl3, Fcrls, Ogfrl1 and Reg3b) were consistently differentially expressed across all age groups. We also generated a temporal profile of cell-type proportions and observed reductions in microglia and astrocytes, along with a trend towards increased ventral neuron populations. Additionally, we characterized the temporal splicing alterations in the spinal cord of DM1 mice and compared with homologous exon skipping events in the CNS of DM1 patients. Our RNA sequencing data elucidate the molecular and cellular adaptations of the spinal cord to muscle defects over time, underscoring that splicing abnormalities observed in the CNS of DM1 patients may reflect contributions from muscle pathology. These findings highlight the necessity of a holistic approach to comprehensively understand the complexity of DM1.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf313","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:41:53Z","timestamp":1755862913000},"source":"Crossref","is-referenced-by-count":1,"title":["Muscle-driven spinal cord histological and transcriptomic alterations in a myotonic dystrophy mouse model: insights into neuropathy"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0942-8778","authenticated-orcid":false,"given":"Guanzhong","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Neurology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"Xiangya School of Medicine, Central South University , Changsha 410013 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"Xiangya School of Medicine, Central South University , Changsha 410013 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"Xiangya School of Medicine, Central South University , Changsha 410013 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangzhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"Xiangya School of Medicine, Central South University , Changsha 410013 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"Xiangya School of Medicine, Central South University , Changsha 410013 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyi","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"issue":"3","key":"2025090913323119200_fcaf313-B1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000524734","article-title":"Global prevalence of myotonic dystrophy: An updated systematic review and meta-analysis","volume":"56","author":"Liao","year":"2022","journal-title":"Neuroepidemiology"},{"issue":"5","key":"2025090913323119200_fcaf313-B2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/WCO.0000000000000128","article-title":"Myotonic dystrophy: Diagnosis, management and new therapies","volume":"27","author":"Turner","year":"2014","journal-title":"Curr Opin 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