{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:14:08Z","timestamp":1758672848796,"version":"3.44.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":251,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sichuan Provincial Science and Technology Department","award":["2024ZYD0136"],"award-info":[{"award-number":["2024ZYD0136"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371479"],"award-info":[{"award-number":["82371479"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health China"},{"name":"BuChangZhiYuanPublic","award":["HIGHER2023073"],"award-info":[{"award-number":["HIGHER2023073"]}]},{"name":"Science and Technology Department","award":["2024-YF05-00958-SN"],"award-info":[{"award-number":["2024-YF05-00958-SN"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sleep duration and Apolipoprotein E genotype are critical factors influencing Alzheimer\u2019s disease progression. This study investigates the interaction between sleep duration and Apolipoprotein E genotype on the functional connectivity of the locus coeruleus in clinically unimpaired older adults with elevated amyloid beta, a population at risk for pre-clinical Alzheimer\u2019s disease. The study included 692 clinically unimpaired older adults with elevated amyloid beta participants from the Anti-Amyloid Treatment in Asymptomatic Alzheimer\u2019s Study (A4). Resting-state functional MRI data were analysed to construct locus coeruleus-based functional connectivity networks, and a 2 \u00d7 2 analysis of covariance was conducted to examine the main and interactive effects of sleep duration (normal versus short sleep) and Apolipoprotein E genotype (\u025b4\u2212 versus \u025b4+) on locus coeruleus-functional connectivity. Structural equation modelling was used to explore whether locus coeruleus-functional connectivity mediated the relationship between age and cognitive performance. Significant main effects of sleep duration and Apolipoprotein E genotype on locus coeruleus-functional connectivity were observed in the right temporal pole, middle cingulate cortex, and superior temporal gyrus. An interactive effect of sleep and Apolipoprotein E genotype was noted, influencing left locus coeruleus-functional connectivity in regions in the precentral gyrus, and right locus coeruleus-functional connectivity network in the middle temporal gyrus and lateral orbitofrontal cortex. Mediation analysis revealed that locus coeruleus-functional connectivity in the middle cingulate cortex and lateral orbitofrontal cortex partially mediated age associated cognitive decline. These findings suggest that locus coeruleus-functional connectivity networks, influenced by sleep duration and Apolipoprotein E genotype, play a crucial role in cognitive aging, particularly in memory function. Understanding these interactions may inform early intervention strategies to preserve cognitive health in older adults at risk for Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf341","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T15:00:20Z","timestamp":1757430020000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>APOE<\/i> genotype modulates the impact of sleep duration on locus coeruleus functional connectivity in pre-clinical Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9807-8049","authenticated-orcid":false,"given":"Liang","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Neurology, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People\u2019s Hospital , Chengdu, Sichuan 610017 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