{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:56:41Z","timestamp":1767772601069,"version":"3.46.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":268,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82503056"],"award-info":[{"award-number":["82503056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangzhou Municipal Basic and Applied Basic Research Program","award":["2024A04J3986"],"award-info":[{"award-number":["2024A04J3986"]}]},{"name":"Guangdong Provincial Clinical Research Center for Rehabilitation Medicine","award":["2023B110003"],"award-info":[{"award-number":["2023B110003"]}]},{"name":"Guangdong Provincial Administration of Traditional Chinese Medicine Research Program","award":["20251065"],"award-info":[{"award-number":["20251065"]}]},{"name":"Guangdong Hopson-Pearl River Education Development Foundation","award":["H20190116202012724"],"award-info":[{"award-number":["H20190116202012724"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Abnormal central pain sensitization is a possible explanation for persistent neuropathic pain after carpal release. However, its exact mechanism remains unclear. This study examined the cortical patterns in chronic neuropathic pain secondary to recurring median neuropathy. Forty-nine patients with recurrent painful carpal tunnel syndrome and 22 age- and sex-matched controls were enrolled. Multimodal MRI, including structural, blood oxygenation level-dependent, and three-dimensional pseudo-continuous arterial spin labelling were employed. Cerebral blood flow and seed-based functional connectivity were analysed. Global and regional cerebral blood flow in several brain regions in the recurring carpal tunnel syndrome group decreased. Significant between-group differences were found in cerebral blood flow maps involving the frontal gyrus and insula, which exhibited an inverse correlation with central sensitization scores. Increased brain connectivity was noted in recurrent carpal tunnel syndrome patients and was negatively correlated with symptom severity. Individuals with chronic neuropathic pain secondary to recurrent median nerve entrapment manifested maladaptive brain networks in cortical regions involving sensory, cognitive and affective processing. Our findings may highlight new avenues for cortical biomarkers and potential mechanisms underlying central sensitization in persistent pain after peripheral neuropathy, which may facilitate innovative targeted management strategies for those who respond poorly to concurrent treatment regimes.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf375","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:04:30Z","timestamp":1758801870000},"source":"Crossref","is-referenced-by-count":1,"title":["Altered patterns in the prefrontal cortex and limbic system in female patients with neuropathic pain secondary to recurrent median nerve entrapment post carpal tunnel release"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8266-6313","authenticated-orcid":false,"given":"Beibei","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou 510655 ,","place":["China"]},{"name":"Department of Orthopaedics & Traumatology, The University of Hong Kong , 999077 Hong Kong SAR ,","place":["China"]},{"name":"Guangdong Provincial Clinical Research Center for Rehabilitation Medicine , Guangzhou 510655 ,","place":["China"]},{"name":"Biomedical Innovation Center, the Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou 510655 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0908-8499","authenticated-orcid":false,"given":"Chen","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou 510655 ,","place":["China"]},{"name":"Guangdong Provincial Clinical Research Center for Rehabilitation Medicine , Guangzhou 510655 ,","place":["China"]},{"name":"Biomedical Innovation Center, the Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou 510655 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