{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:31:50Z","timestamp":1791495110216,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":278,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012066","name":"Wings for Life","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001708","name":"International Foundation for Research in Paraplegia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nordrhein-Westfalen"},{"name":"Roger De Spoelberch Prize"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Rehabilitation is widely recognized as an essential component in evaluating the effectiveness of a therapeutic intervention in animal models of translational spinal cord injury research. Ideally, the rehabilitation method used should be optimized for the specific injury model and severity to adequately compare the efficacy of the investigational therapy. For studies utilizing thoracic spinal cord injuries, rehabilitation primarily involves bipedal or quadrupedal treadmill training aimed at restoring hindlimb function. Previously, we reported modest improvements to hindlimb motor recovery following forced bipedal treadmill training after moderate 175 kilodyne thoracic spinal cord contusion injury, which were further enhanced when combined with the microtubule-stabilizing drug epothilone B. However, during this and other studies we have noted that B-TMT presents several potential limitations, including brief periods of active rehabilitation for each animal, variability between animal handlers, animal stress, and the focus on a single movement pattern. To overcome these limitations, we investigated the effects of an environmental enrichment-based rehabilitation that differs from a general environment enrichment strategy by including task-specific training elements, something we have termed \u2018targeted environmental enrichment\u2019. This method provides longer periods of active rehabilitation, operates independently of the animal handler, thereby involves less animal handling, which minimizes stress, and encourages a wide range of movements. Our findings indicate that targeted environmental enrichment outperforms bipedal training across several behavioural measures which produced a ceiling effect that epothilone B could not overcome. Therefore, these results suggest that targeted environmental enrichment may be a more effective rehabilitation approach than B-TMT and should be considered for application in models of severe spinal cord injury.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf385","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T13:56:51Z","timestamp":1759759011000},"source":"Crossref","is-referenced-by-count":5,"title":["Targeted environmental enrichment is more effective than bipedal treadmill training after thoracic spinal cord injury"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3013-8057","authenticated-orcid":false,"given":"Jarred M","family":"Griffin","sequence":"first","affiliation":[{"name":"Cure Programme, Faculty of Medical and Health Sciences, The University of Auckland , Auckland 1023 ,","place":["New Zealand"]},{"name":"School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland , Auckland 1023 ,","place":["New Zealand"]},{"name":"Laboratory for Axonal Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE) , Bonn 53127 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Bockem\u00fchl","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology, Institute of Zoology, University of Cologne , Cologne 50674 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Randel","sequence":"additional","affiliation":[{"name":"Laboratory for Axonal Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE) , Bonn 53127 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Gr\u00f6schl","sequence":"additional","affiliation":[{"name":"Laboratory for Axonal Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE) , Bonn 53127 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"Cure Programme, Faculty of Medical and Health Sciences, The University of Auckland , Auckland 1023 ,","place":["New Zealand"]},{"name":"School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland , Auckland 1023 ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"B\u00fcschges","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology, Institute of Zoology, University of Cologne , Cologne 50674 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bradke","sequence":"additional","affiliation":[{"name":"Laboratory for Axonal Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE) , Bonn 53127 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"issue":"1","key":"2025101605574233200_fcaf385-B1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5312\/wjo.v6.i1.8","article-title":"Rehabilitation of spinal cord injuries","volume":"6","author":"Nas","year":"2015","journal-title":"World J Orthop"},{"issue":"21 Suppl","key":"2025101605574233200_fcaf385-B2","doi-asserted-by":"crossref","first-page":"S259","DOI":"10.1097\/BRS.0b013e3181f1a979","article-title":"Rehabilitation in spine and spinal cord trauma","volume":"35","author":"Labruyere","year":"2010","journal-title":"Spine (Phila Pa 1976)"},{"issue":"3","key":"2025101605574233200_fcaf385-B3","doi-asserted-by":"crossref","first-page":"e11505","DOI":"10.15252\/emmm.201911505","article-title":"Therapeutic repair for spinal cord injury: Combinatory approaches to address a multifaceted problem","volume":"12","author":"Griffin","year":"2020","journal-title":"EMBO Mol Med"},{"issue":"5","key":"2025101605574233200_fcaf385-B4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3390\/cells13050412","article-title":"Do pharmacological treatments act in collaboration with rehabilitation in spinal cord injury treatment? 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