{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T01:49:25Z","timestamp":1783561765995,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":287,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-EY028125"],"award-info":[{"award-number":["R01-EY028125"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30-EY026877"],"award-info":[{"award-number":["P30-EY026877"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["G2016030"],"award-info":[{"award-number":["G2016030"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["G2021001F"],"award-info":[{"award-number":["G2021001F"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Pittsburgh School of Medicine"},{"DOI":"10.13039\/100016027","name":"New York University Grossman School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006521","name":"Stanford University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006521","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Glaucoma patients often have higher injurious fall rates compared to healthy older adults. However, little is known about the underlying neural mechanisms. Recent evidence shows cerebral changes beyond the visual pathway of glaucoma patients, yet it remains unclear whether the cerebellum, which plays an important role in balance and motor control, is involved in glaucoma. In this study, we sought to investigate cerebellar functional connectivity changes in glaucoma by comparing 32 glaucoma subjects and 10 age-matched healthy control subjects who underwent resting-state functional magnetic resonance imaging at 3 Tesla with eyes closed. After conducting both regions-of-interest and seed-to-voxel analyses, we found that the functional connectivity within the cerebellum tended to be weakened in glaucoma patients compared to healthy controls, whereas the functional connectivity between some cerebral and cerebellar regions showed opposite changes in the same glaucoma subjects. Our findings underscore the potential role of cerebellar and cerebro-cerebellar dysfunction in postural and cognitive control in glaucoma patients. Taken together, these observations implicate the widespread brain changes in glaucoma beyond the cerebral regions into the cerebellum that may underlie the neural underpinnings of impaired balance control in this disease.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf401","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:21:19Z","timestamp":1760448079000},"source":"Crossref","is-referenced-by-count":1,"title":["Cerebellar dysfunction in glaucoma patients"],"prefix":"10.1093","volume":"7","author":[{"given":"Anisha","family":"Kasi","sequence":"first","affiliation":[{"name":"New York University Grossman School of Medicine, NYU Langone Health, New York University , New York, NY 10017 ,","place":["USA"]},{"name":"Icahn School of Medicine at Mount Sinai , New York, NY 10029 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Bang","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine, NYU Langone Health, New York University , New York, NY 10017 ,","place":["USA"]},{"name":"Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine , Palo Alto, CA 94303 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Trivedi","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine, NYU Langone Health, New York University , New York, NY 10017 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannie M","family":"Au","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine, NYU Langone Health, New York University , New York, NY 10017 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian P","family":"Conner","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, University of Pittsburgh , Pittsburgh, PA 15213 ,","place":["USA"]},{"name":"Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh , Pittsburgh, PA 15213 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadi","family":"Wollstein","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, Glaucoma Service and Vickie and Jack Farber Vision Research Center , Philadelphia, PA 19107 ,","place":["USA"]},{"name":"Sidney Kimmel Medical College of Thomas Jefferson University , Philadelphia, PA 19107 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel S","family":"Schuman","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, Glaucoma Service and Vickie and Jack Farber Vision Research Center , Philadelphia, PA 19107 ,","place":["USA"]},{"name":"Sidney Kimmel Medical College of Thomas Jefferson University , Philadelphia, PA 19107 ,","place":["USA"]},{"name":"Drexel University School of Biomedical Engineering, Science and Health Studies , Philadelphia, PA 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakie","family":"Cham","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, University of Pittsburgh , Pittsburgh, PA 15213 ,","place":["USA"]},{"name":"Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh , Pittsburgh, PA 15213 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-7084","authenticated-orcid":false,"given":"Kevin C","family":"Chan","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine, NYU Langone Health, New York University , New York, NY 10017 ,","place":["USA"]},{"name":"Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine , Palo Alto, CA 94303 ,","place":["USA"]},{"name":"Department of Ophthalmology, School of Medicine, University of Pittsburgh , Pittsburgh, PA 15213 ,","place":["USA"]},{"name":"Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh , Pittsburgh, PA 15213 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"issue":"7","key":"2025112901522904300_fcaf401-B1","first-page":"771","article-title":"Falls in the elderly: Spectrum and prevention","volume":"57","author":"Al-Aama","year":"2011","journal-title":"Can Fam Physician"},{"issue":"3","key":"2025112901522904300_fcaf401-B2","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1167\/iovs.06-0886","article-title":"Risk of falls and motor vehicle collisions in glaucoma","volume":"48","author":"Haymes","year":"2007","journal-title":"Invest Ophthalmol Vis 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